王瑾(西安交大一附院神經內科副主任醫師)

王瑾，女，博士，碩士研究生導師，副主任醫師，現任西安交大一附院神經內科副主任醫師

基本介紹

• 中文名：王瑾  
• 國籍：中國
• 畢業院校：西安交通大學醫學院 
• 臨床職稱：副主任醫師 
• 主要執業機構：西安交通大學第一附屬醫院 
• 執業證書編碼：110610000003629 

人物經歷

教育經歷

1999/09-2004/09 西安交通大學醫學院，醫學學士

2004/09-2006/07 西安交通大學醫學院，醫學碩士

2010/09-2019/06 西安交通大學醫學院，臨床醫學博士

工作經歷

2006/07-2009/05 西安交通大學第一醫院神經內科 住院醫師

2009/05-2018/12 西安交通大學第一醫院神經內科 主治醫師

2019/01-今 西安交通大學第一醫院神經內科 副主任醫師

擅長領域

痴呆與認知障礙

研究方向

主要從事認知功能障礙的臨床和基礎研究，參與多項臨床研究

社會職務

中國微循環學會神經變性病專業委員會青年委員

中國老年醫學學會認知障礙分會青年委員

陝西省醫學會神經病學分會痴呆與認知障礙學組委員兼秘書

陝西省抗癲癇協會認知障礙與癲癇專業委員會委員兼秘書

中國微循環學會神經變性病專業委員會阿爾茨海默病生物標誌物學組第一屆委員會常務委員

科研項目

[1]陝西省科技廳一般項目-社會發展領域:睡眠剝奪對腦組織內環境穩定的影響及其機制研究。項目編號：2022SF-177.2022.3.1-2024.3.1.

[2]西安交通大學第一附屬醫院橫向課題：中重度阿爾茨海默病患者單用或聯合使用美金剛與甘露特鈉膠囊的療效及安全性研究。項目編號：HX202259.2022.1.1-2024.12.31.

[3]西安交通大學第一附屬醫院院基金：血漿轉運蛋白sLRP1影響腦內Aβ沉積分子機制研究。項目編號：2019QN-22. 2020.1-2022.12.

[4]陝西省科技廳一般項目-社會發展領域:糖尿病促進AQP4內化影響Aβ清除的機制研究.項目編號：2017SF-260. 2017.01.01-2018.12.31.

[5]西安交通大學第一附屬醫院臨床研究基金：多奈哌齊聯合丁苯酞治療對輕中度阿爾茨海默病進展的影響.課題編號：XJTU1AF-CRF-2015-027.2016.01-2017.12.

學術論文

英文期刊論文

[1] Jin Wang, Ling Gao, Jie Liu, Liangjun Dang, Shan Wei, Ningwei Hu, Yao Gao, Wei Peng, Suhang Shang, Kang Huo, Jingyi Wang, Qiumin Qu.The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population.Clinical Interventions in Aging. 2022;17:555–565. (IF=4.458)

[2] Wang J, Guo X, Lu W, Liu J, Zhang H, Quan Q, Su H, Ma L, Gao F, Qu Q*.Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer’s Disease: A Multicenter, Prospective Cohort Study.J Alzheimers Dis. 2021;80(2):673-681. (IF=4.472)

[3] Jin Wang, Fan Qiao, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Yu Jiang, Kang Huo, Meiying Deng, Jingyi Wang and Qiumin Qu. Elevation of Plasma Amyloid-βLevel is More Significant in Early Stage of Cognitive Impairment: A Population-Based Cross-Sectional Study.Journal of Alzheimer’s Disease，2018，64:61–69.(IF=3.517)

[4] Gao, L.,Wang J., Jiang Y.,Wei S.,Shang S., Chen C., Dang L.,Huo K., Deng M., Wang J.,Qu Q. Relationship Between Peripheral Transport Proteins and Plasma Amyloid-β in Patients with Alzheimer's Disease were Different from Cognitively Normal Controls: A Propensity Score Matching Analysis. J Alzheimers Dis. 2020;78(2):699-709.（IF=3.909）

[5] Ping Li, Yongning Deng, Xiaojuan Guo,Jin Wang. Nursing effects of finger exercise on cognitive function and others for cerebral ischemic stroke patients. Am J Transl Res 2021;13(4):3759-3765.（IF=4.06）

[6] Ling Gao, Liangjun Dang, Shan Wei, Ningwei Hu, Fan Gao, Wei Peng, Suhang Shang,Yi Zhao, Chen Chen, Xiaojuan Guo, Kang Huo, Jingyi Wang,Jin Wangand Qiumin Qu.Peripheral Transport Proteins Were Associated with 4-Year Cognitive Decline in APOE 4 Non-Carriers: A Longitudinal, Population-Based Study.Journal of Alzheimer’s Disease. 2022; 86: 801–812.(IF=4.472)

[7] She M, Shang S, Hu N, Chen C, Dang L, Gao L, Wei S, Huo K, Wang J,Wang J*and Qu Q*. Blood Pressure Level Is Associated With Changes in Plasma Abeta1 -40 and Abeta1-42 Levels: A Cross-sectional Study Conducted in the Suburbs of Xi'an, China. Front Aging Neurosci 2021;13:650679.(IF=5.75)

[8] Wei S, Shang S, Dang L, Gao F, Gao Y, Gao L,Chen C, Huo K, Wang J,Wang J*and Qu Q*. Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-beta Transport: A Population-Based Cross-Sectional Study. J Alzheimers Dis 2021;84:303-314. (IF=4.472)

[9] Wang Y, Wei S, Zhou R, Shang S, Dang L, Gao L, Chen C, Huo K, Wang J,Wang J*and Qu Q*.The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi’an, China. Front Aging Neurosci 2021;13:761886. (IF=5.75)

[10]Gao Y#, Wei S #, Gao F, Gao L, Dang L, Shang S, Chen C, Huo K, Wang J,Wang J*and Qu Q*. Sleep disturbance is associated with higher plasma Aß levels - A population-based cross-sectional study. Front. Aging Neurosci. 2020; 12: 44(IF=4.362)

[11]Shang S, Liu Z, Gao J,Wang J，et al. The Relationship Between Pre-existing Coronary Heart Disease and Cognitive Impairment Is Partly Explained by Reduced Left Ventricular Ejection Fraction in the Subjects Without Clinical Heart Failure: A Cross-Sectional Study. Front Hum Neurosci. 2022;16:835900.（IF=3.16）

[12]Gao, F.,Shang S., Chen C, Dang L., Gao L , Wei S.,Wang J., Huo K., Deng M., Wang J., Qu Q. Non-linear Relationship Between Plasma Amyloid-β 40Level and Cognitive Decline in a Cognitively Normal Population. Front Aging Neurosci, 2020. 12: p. 557005.（IF=4.362）

[13]Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, Wang J, Huo K, Wang J, Zhang R, Qu Q*. The Apolipoprotein Eε4 Allele-Dependent Relationship Between Serum Lipid Levels and Cognitive Function: A Population-Based Cross-sectional Study. Front. Aging Neurosci. 2020; 12: 44. (IF=4.362)

[14]Liu P#, Zhao B#, Wei M, Li Y, Liu J, Ma L, Shang S, Huo K, Wang J, Li R, Qu Q*. Activation of Inflammation is Associated with Aβ Accumulation Induced by Chronic Sleep Restriction in Rats. J Alzheimers Dis. 2020; 74(3): 759-773.(IF=3.909)

[15]Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, Zhao B, Zhang J,Wang J, Huo K, Wang J, Zhang R, Qu Q.Apolipoprotein E ε4 Allele is Associated With Plasma Amyloid Beta and Amyloid Beta Transporter Levels: A Cross-sectional Study in a Rural Area of Xi'an, China.Am J Geriatr Psychiatry. 2020；28（2）：194-204.（IF=3.488）

[16]Hu N , Gao L , Jiang Y, Wei S, Shang S, Chen C, Dang L,Wang J, Huo K, Deng M, Wang J, Qu Q . The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study. Lipids Health Dis. 2020 Jan 14; 19(1): 8. (IF=2.651)

[17]Zhao B, Liu P, Wei M, Li Y, Liu J, Ma L, Shang S, Jiang Y, Huo K,Wang J, Qu Q.Chronic Sleep Restriction Induces Aβ Accumulation by Disrupting the Balance of Aβ Production and Clearance in Rats.Neurochem Res. 2019;44(4):859-873. (IF=2.782)

[18]Zhao B, Shang S, Li P, Chen C, Dang L, Jiang Y,Wang J, Huo K, Deng M, Wang J, Qu Q.The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi'an, China.Lipids Health Dis. 2019;18(1):4. (IF=2.651)

[19]Jiang Y, Shang S, Li P, Chen C, Dang L,Wang J, Huo K, Deng M, Wang J, Qu Q. Pulse Pressure Is Associated With Plasma Amyloid-β Transport Dysfunction. J Hypertens. 2018; 36(3): 569-579. (IF=4.092)

[20]Gao L, Jiang Y, Wei S, Shang S, Li P, Chen C, Dang L,Wang J,Huo K, Deng M, Wang J, Zhang R, Qu Q.The Level of Plasma Amyloid-β40 Is Correlated with Peripheral Transport Proteins in Cognitively Normal Adults: A Population-Based Cross-Sectional Study.J Alzheimers Dis. 2018; 65(3): 951- 961. (IF=3.517)

[21]Jin Qiao, Wen-Hui Lu,Jin Wang, Xiao-Juan Guo, Qiu-Min Qu. Vascular Risk Factors Aggravate the Progression of Alzheimer's Disease: A 3-Year Follow-Up Study of Chinese Population. American Journal of Alzheimer's Disease and Other Dementias.2014; 29(6):521-5. (IF=1.614)

中文期刊論文

[1] 王瑾，張彬艷，商蘇杭，李珮，鄧美英，江毓，陳晨，屈秋民.西安市農村居民高血壓與血脂水平的相關性研究.蘭州大學學報（醫學版）.2018,44(6):14-19.

[2] 王瑾，李再利，顏飛，商蘇杭，李珮，陳晨，鄧美英，屈秋民.腦卒中高危人群認知功能障礙血管性危險因素篩查.中國現代神經疾病雜誌.2017;17(2):138-142.

[3] 王瑾，商清，劉蕊，屈秋民.腦血管反應性降低與高血壓認知功能減退的相關性研究.醫學研究生學報.2016;29(12):1260-1264.

[4] 王瑾，王瑩，葉雯，喬晉，屈秋民.新編痴呆自查問卷在痴呆篩查中的套用價值初探.中國現代神經疾病雜誌.2015;15(7):554-559.

[5] 郜錦英,商蘇杭,霍康,王瑾,屈秋民.左心室射血分數與認知損害的關係.中華老年心腦血管病雜誌. 2015;17(12): 1271-4.

[6] 何芸,霍康,王瑾,屈秋民.高血壓患者直立性低血壓與認知功能減退相關.中華高血壓雜誌. 2015;23(7):639-43.

[7] 賈蕊,劉蕊,杜亞娟,王瑾,羅國剛.卵圓孔未閉導致反覆跌倒發作2例.中國臨 床神經科學2014;04: 430-432.