基本介紹
- 中文名：王明齊
- 畢業院校：四川大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：有機化學
- 任職院校：江蘇大學
個人經歷,研究方向,學術成果,
個人經歷
教育經歷：
2005.09-2009.06 淮陰師範學院，化學專業，獲學士學位
2009.09-2014.07 四川大學，有機化學專業，獲博士學位
工作經歷：
2012.06-2013.01岡山大學（Okayama University），日本，國際交流合作
2014.07-至今 江蘇大學藥學院 講師
2016.12-至今 江蘇大學，博士後
研究方向
1、 核酸藥物化學和核酸化學生物學
2、 自組裝螢光納米探針
3、化學生物感測
學術成果
科研項目（項目負責人）：
1、 端粒G4-DNA為靶點的喹啉類衍生物結構修飾及機理研究，中國博士後科學基金，主持
2、 端粒DNA識別分子的核酸調控及相關信號轉導干預研究，江蘇高等學校自然科學研究面上項目，主持
3、 基於深紅/近紅外兩親性BODIPY螢光分子自組裝：分子設計、G-四鏈體DNA識別與生物套用，江蘇省青年科學基金，主持
4、 G-四鏈體DNA螢光探針分子的設計合成及其抗腫瘤活性研究，江蘇大學高級人才啟動，主持，已結題
代表性論著（第一作者和通訊作者論文）：
[1] Wang Ming-Qi*, Xu Jing, Zhang Lan, Liao Yue, Wei Heng, Yin Ying-Ying, Liu Qiang*, Zhang Lan. Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA. Bioorganic & Medicinal Chemistry, 2019
[2] Wang Ming-Qi*, Ren Gui-Ying, Zhao Shuang, Lian Guang-Chang, Chen Ting-Ting, Ci Yang, Li Hong-Yao. Development of a carbazole-based fluorescence probe for G-quadruplex DNA: The importance of side-group effect on binding specificity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018
[3] Zhang Feng, Li Gan, Lv Fang-Lei, Jiang Guang-Bin, Wang Han-Xiang, Wang Ming-Qi*, Li Shuo*. A far-red fluorescent probe for selective G-quadruplex DNA targeting. Tetrahedron Letters 2018
[4] Wang Ming-Qi*, Liu Xiao-Ning, Guo Zhong-Jian*, Feng chunlai*, Rui mengjie, Synthesis of quinolinium-based probes and studies of their effects for selective G-quadruplex DNA targeting, New Journal of Chemistry, 2018
[5] Wang Ming-Qi*, Wu Yuan, Wang Zi-Yu, Chen Qiu-Yun*, Xiao Fu-Yan, Jiang Yu-Chi, Sang Amy, G-quadruplex DNA fluorescence sensing by a bis-amine-substituted styrylquinolinium dye, Dyes and Pigments, 2017
[6] Wang Ming-Qi*, Wang Zi-Yu, Yang Yi-Fan, Ren Gui-Ying, Liu Xiao-Ning, Li Shuo*, Wei Jian-Wei, Zhang Lan, Development of a light-up fluorescent probe for HRAS G-quadruplex DNA. Tetrahedron Letters, 2017
[7]Wang Ming-Qi*, Liu Shuo, Tang Cai-Ping, Raza Aun, Li Shuo*, Gao Lie-Xiong, Sun Jing*, Guo Song-Ping, Flexible amine-functionalized triphenylamine derivative as a fluorescent “light-up” probe for G-quadruplex DNA, Dyes and Pigments, 2017
[8] Wang Ming-Qi, Gao Lie-Xiong, Yang Yi-Fan, Xiong Xian-Ning, Zheng Zhao-Yi, Li Shuo*, Wu Yuan, Ma Lu-Lu, A triphenylamine derivative as a naked-eye and light-up fluorescent probe for G-quadruplex DNA, Tetrahedron Letters, 2016
[9] Wang Ming-Qi*, Dong Juan, Zhang Huafan, Tang Zhuo*.Characterization of deoxyribozymes with site-specific oxidative cleavage activity against DNA obtained by in vitro selection, Organic & Biomolecular Chemistry, 2016
[10] Wang Ming-Qi*, Zhu Wen-Xiang, Song Zhuan-Zhuan, Li Shuo*, Zhang Yong-Zhao, A triphenylamine-based colorimetric and fluorescent probe with donor–bridge–acceptor structure for detection of G-quadruplex DNA, Bioorganic & Medicinal Chemistry Letters, 2015
[11] Wang Ming-Qi, Zhang Hua-Fan, Zhang Wei, Zhao Yong-yun, Yasmeen Afshan, Zhou Li, Yu Xiao-Qi*, Tang Zhuo*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity, Nucleic Acids Research, 2014
[12] Wang Ming-Qi, Li Kun*, Xu Hao-Ran, Yu Xiao-Qi*, Imidazolium-based 1,1’-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water, Analytical Methods, 2013
[13] Wang Ming-Qi, Li Kun*, Hou Li-Ting, Wu Ming-Yu, Huang Zeng, Yu Xiao-Qi*, BINOL-Based fluorescent sensor for recognition of Cu(II) and sulfide anion in water, Journal of Organic Chemistry, 2012
[14] Wang Ming-Qi, Zhang Ji, Zhang Yu, Zhang Da-Wei, Liu Qiang, Liu Jun-Liang, Lin Hong-Hui*, Yu Xiao-Qi*, Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine, Bioorganic & Medicinal Chemistry Letters, 2011
[15] Wang Ming-Qi, Liu Jun-Liang, Wang Jing-Yi, Zhang Da-Wei, Zhang Ji, Streckenbach Frank, Tang Zhuo*, Lin Hong-Hui*, Liu Yan, Zhao Yu-Fen, Yu Xiao-Qi*, Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate, Chemical Communications, 2011
授權發明專利：
[1] 一種具有電荷轉移特性的螢光探針及其製備方法和用途。
[2] 一種α-Fe2O3磁性納米棒的製備方法。
