清華大學生命科學學院教授，清華-北大生命科學聯合中心PI，結構生物學家。2016年4月接替國際著名結構生物學家施一公院士成為清華大學生命科學學院成立以來第三任院長。
基本介紹
- 中文名：王宏偉
- 外文名：Hongwei Wang
- 別名：老王
- 國籍：中國
- 民族：滿族
- 出生地：遼寧瀋陽
- 出生日期：1974年1月27日
- 職業：教授
- 畢業院校：清華大學
- 信仰：共產主義
- 主要成就：中國冷凍電鏡領域翹楚
- 代表作品：微管組裝
- 婚姻狀態：已婚
人物生平,主要成就,出版著作,
人物生平
1992-1996 清華大學生物科學與技術系，學士
1996-2001 清華大學生物科學與技術系，博士
2001-2006 美國勞倫斯伯克利國家實驗室生命科學部，博士後
2006-2008 美國勞倫斯伯克利國家實驗室生命科學部，研究科學家
2009-2011 美國耶魯大學分子生物物理與生物化學系，Tenure-Track助理教授
2010.12-至今 清華大學生命科學學院，教授、博導
主要成就
王宏偉教授長期致力於使用冷凍電鏡技術研究生物大分子的結構以及其組裝機制，研究領域集中在細胞骨架動態機理、RNA降解、RNA干擾以及冷凍電鏡方法學。目前已獲得微管和Exosome等的高分辨電鏡結構。此外，王宏偉教授還與其他課題組合作，解析了一批具有重要生物學意義的生物大分子的結構。
出版著作
1. Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G,Wang HW*, and Liu Y*. (2015) Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution.Mol. Cell,57, 925-935. (*co-corresponding authors)
2. Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, andWang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.Nat. Struct. Mol. Biol.,21, 95-102. (*co-corresponding authors)
3. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC,Wang HW, and Ye S. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.Science,341: 392-295.
4. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, andWang HW*. (2013) Substrate-specific structural rearrangements of human Dicer.Nat. Struct. Mol. Biol.,20, 662-670. (*co-corresponding authors)
5. Chen X, Taylor DW, Fowler CC, Galan JE,Wang HW, and Wolin SL. (2013) An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA.Cell,153: 166-177.
6. Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, andWang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodeling.J. Cell Biol.,199, 111-124. (*co-corresponding authors)
7. Zhou K, Kanai R, Lee P,Wang HW*, and Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.J. Struct. Biol.,177: 402-409 (*co-corresponding authors)
8. Liu XQ andWang HW. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method.J. Vis. Exp.,doi: 10.3791/2574.
9. Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L,Wang HWand Fuchs E. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β.Cell,144, 341-352.
10.WangHW*, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA*, and Nogales E*. (2009) Structural insights into RNA processing by the human RISC-loading complex.Nat. Struct. Mol. Biol.,16, 1148-1153. (* co-corresponding authors)
11.Wang HW, Long S, Ciferri C, Westermann S, Drubin DG, Barnes G, and Nogales E. (2008) Architecture and flexibility of the yeast Ndc80 kinetochore complex.J. Mol. Biol.,383, 894-903.
12.Wang HW*, Wang J, Ding F, Callahan K, Bratkowski MA, Bulter JS, Nogales E, and Ke A*. (2007) Architecture of the yeast Rrp44-exosome complex suggests routes of RNA recruitment for 3’-end processing.Proc. Natl. Acad. Sci. USA,104, 16844-16849. (* co-corresponding authors)
13.Wang HW, Ramey VH, Westermann S, Leschziner A, Welburn JPI, Nakajima Y, Drubin DG, Barnes G, and Nogales E. (2007) Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms.Nat. Struct. Mol. Biol.,14, 721-726.
14. Nogales E andWang HW.(2006)Structural intermediates in microtubule assembly and disassembly: how and why?Curr. Opin. Cell Biol.,18, 179-284.
15. Westermann W,Wang HW, Avila-Sakar A, Drubin DG, Nogales E, and Barnes G. (2006)The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.Nature,440, 565-563.
16.Wang HWand Nogales E. (2005) The nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly.Nature,435, 911-915.
