潘寶成，潘寶成，生物物理學博士，副教授，中山大學新華學院資訊管理系專職教師。1998年畢業於美國俄亥俄州立大學哥倫布分校，生物物理學專業。曾在耶魯大學分子生物物理和分子生物化學系進行結構生物學研究，師從諾貝爾獎得主Thomas A. Steitz 。研究RNA聚合酶的分子結構、功能以及催化機理。所設計的具有化學反應活性的結晶系統方法準確地揭示了蛋白質和核酸的相互作用機理，為X-光晶體學研究生物複合體相互作用機理提供了一種更可靠的方法，其研究成果發表在《科學》雜誌上。現研究方向是理論生物學，試圖從理論的角度來探討生物學的基本問題、基本過程及其規律。
基本介紹
- 中文名：潘寶成
- 職業：教師
教育經歷,工作經歷,研究方向,
教育經歷
1978/10–1982/07，暨南大學，物理系，學士
1984/09–1987/07，暨南大學，物理系，碩士
1990/09–1998/07，俄亥俄州立大學, 生物物理系, 博士
工作經歷
1982/09–1984/08，廣州民航技術學院，基礎部，教師
1987/08–1990/07，暨南大學，物理系，教師
1998/08–2003/09，俄亥俄州立大學，化學系, Postdoctoral Researcher
2003/10–2009/08，耶魯大學，分子生物物理和生物化學系，Postdoctoral Associate
2009/09–2010/02，耶魯大學，分子生物物理和生物化學系，Research Associate Scientist
研究方向
理論生物學。試圖從理論的角度來探討生物學的基本問題、基本過程及其規律。
五、期刊論文
25. Pan, B.（#）, Xiong, Y. & Steitz, T. A. (2010) How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science 330, 937-940.
24. Yang, H., Wang, J. Jia, X. McNatt, M. W., Zang, T., Pan, B. Meng, W., Wang, H., Bieniasz, P. D., Xiong, Y. (2010) Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc. Natl. Acad. Soc. USA 107, 18428-18432.
23. Pan, B.（#）, Shi, K. & Sundaralingam, M. (2006) Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex. Proc. Natl. Acad. Soc. USA 103, 3130-3134.
22. Pan, B.（#）（*）, Shi, K. & Sundaralingam, M. (2006) Crystal structure of an RNA quadruplex containing inosine tetrad: implications for the role of NH2 group in purine tetrads. J. Mol. Biol. 363, 451-459.
21. Pan, B.（#）, Shi, K. & Sundaralingam, M. (2004) Synthesis, purification and crystallization of Guanine-rich RNA oligonucleotides. Biol. Proced. Online 6, 257-262.
20. Shi, K., Pan, B., Tippin, D. & Sundaralingam, M. (2004) Structure of d(Gm5CGm5CGCGC) and d(GCGCGm5CGm5C): effects of methylation on alternating DNA octamers. Acta Crystallogr. D 60, 61-65.
19. Eswaramoorthy, S., Rao, S. T., Pan, B. & Sundaralingam, M. (2004) Structure of the dodecamer r(GAUCACUUCGGU) with four 5’-overhanging nucleotides. Acta Crystallogr. D 60, 8-12.
18. Deng, J., Pan, B. & Sundaralingam, M. (2003) Structure of d(ITITACAC) complexed with distamycin at 1.6 Å resolution. Acta Crystallogr. D 59, 2342-2344.
17. Pan, B.（#）, Xiong, Y., Shi, K. & Sundaralingam, M. (2003) Crystal structure of a bulged RNA tetraplex at 1.1 Å resolution: implications for a noval binding site in RNA tetraplex. Structure 11, 1423-1430 (previewed).
16. Shi, K., Pan, B. & Sundaralingam, M. (2003) Structure of a B-form DNA/RNA chimera (dC)(rG)d(ATCG) complexed with daunomycin at 1.5 Å resolution. Acta Crystallogr. D 59, 1377-1383.
15. Pan, B.（#）, Xiong, Y., Deng, J., Shi, K. & Sundaralingam, M. (2003) Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes. Structure 11, 815-823.
14. Pan, B.（#）, Xiong, Y., Shi, K. & Sundaralingam, M. (2003) An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction. Structure 11, 825-831.
13. Deng, J., Xiong, Y., Pan, B. & Sundaralingam, M. (2003) Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli. Acta Crystallogr. D 59, 1004-1011 (cover story).
12. Shi, K., Pan, B. & Sundaralingam, M. (2003) The crystal structure of an alternating RNA heptamer r(GUAUACA) forming a six base-paired duplex with 3’-end adenine overhangs. Nucleic Acids Res. 31, 1392-1397.
11. Ravelli, R. B. G., Leiros, H.-K. S., Pan, B., Caffrey, M. & McSweeney, S. (2003) Specific radiation damage can be used to solve macromolecular crystal structures. Structure 11, 217-224.
10. Pan, B.（#）& Sundaralingam, M. (2003) Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5’-(rG) overhang. Acta Crystallogr. D 59, 433-437.
9. Ramakrishnan, B., Sekharudu, C., Pan, B. & Sundaralingam, M. (2003) Near-atomic resolution crystal structure of an A-DNA decamer d(CCCGATCGGG): cobalt hexammine interaction with A-DNA. Acta Crystallogr. D 59, 67-72.
8. Sundaralingam, M. & Pan, B. (2002) Hydrogen and hydration of DNA and RNA oligonucleotides. Biophys. Chem. 95, 273-282.
7. Pan, B.（#）, Mitra, S. N. & Sundaralingam, M. (1999) Crystal structure of an RNA 16-mer duplex r(GCAGAGUUAAAUCUGC)2 with non-adjacent G(syn)·A+(anti) mispairs. Biochemistry 38, 2826-2831.
6. Pan, B.（#）& Sundaralingam, M (1999) Mismatches in RNA Crystal Structures: Base Pairing, Base Stacking. Perspectives in Structural Biology, 521-544 (Book Chapter).
5. Pan, B.（#）, Sundaralingam, M. (1999) Mismatched Base Pairing in RNA Crystal Structures. Int. J. Quantum Chem. 75, 275-287.
4. Pan, B.（#）, Mitra, S. N. & M. Sundaralingam (1998) Structure of a 16-mer RNA duplex r(GCAGACUUAAAUCUGC)2 with wobble C·A+ mismatches. J. Mol.Biol. 283, 977-984.
3. Pan, B.（#）, Mitra, S. N., Sun, L., Hart, D. & Sundaralingam, M. (1998) Crystal structure of an RNA octamer duplex r(CCCIUGGG)2 incorporating tandem I·U wobbles. Nucleic Acids Res. 26, 5699-5706.
2. Pan, B.（#）, Ban, C., Wahl, M. C. & Sundaralingam, M. (1997) Crystal structure of d(GCGCGCG) with 5'-overhang G residues. Biophys. J. 73, 1553-1561.
1. Gross, E. L., Draheim, J. E., Curtiss, A. S., Crombie, B., Scheffer, A., Pan, B., Chiang, C. & Lopez, A. (1992) Thermal denaturation of plastocyanin: the effect of oxidation state, reductants, and anaerobicity. Arch. Biochem. Biophys. 298, 413-419.
