漆永梅，博士，蘭州大學副教授。
基本介紹
個人經歷,主講課程,研究方向,學術成果,
個人經歷
學習經歷
2005/09-2011/07，蘭州大學，生命科學學院，碩博連讀/博士，導師：張迎梅教授
2008/09-2010/07，美國馬里蘭大學帕克分校（University of Maryland, College Park），“國家建設高水平大學公派研究生項目”聯合培養博士研究生
2001/09-2005/07，河南師範大學，生命科學學院，本科/學士
工作經歷
2016.05-今，蘭州大學，生命科學學院，副教授
2011/07-2016.04，蘭州大學，生命科學學院，講師
2008/07-2011/06，蘭州大學聯合培養研究生師資
主講課程
承擔本科生《生物化學》和《生物化學實驗》課程教學
承擔研究生《環境生物監測-動物學專題》和《動物毒理學》課程教學
研究方向
目前主要從事線粒體自噬和線粒體動態的分子機制研究：
1.以哺乳動物細胞和小鼠為模型研究線粒體自噬和線粒體動態的影響因素及分子機制；
2.以哺乳動物細胞和小鼠為模型探討線粒體穩態與癌症發生髮展、神經退行性疾病的關係及相關分子機制；
3.以斑馬魚為模型探究環境污染物對其神經系統和免疫系統的影響，並從線粒體穩態維持的角度探討其分子機制。
學術成果
論文成果
1.主持國家自然科學基金青年項目，31300941，ROS和ATM蛋白在亞精胺致線粒體自噬過程中的調控機理研究，2014/01-2016/12
2.主持甘肅省自然科學基金項目，145RJZA120，鉛對小鼠腎臟線粒體自噬的影響及機制研究，2014/01-2016/12
3.主持甘肅省自然科學基金項目，1010RJZA107，營養元素調控DNA損傷應答及其延緩衰老和預防癌症的分子機理，2010/01-2012/12
4.主持中央高校基本科研業務費自由探索麵上項目，lzujbky-2014-91，鉛對人胚腎細胞線粒體自噬的影響及作用機制，2014/01-2015/12
代表性論文（通訊作者）：
1.Sajid Naeem, Yongmei Qi*, Yihong Tian, Yingmei Zhang*. NIX compensates lost role of Parkin in Cd-induced mitophagy in HeLa cells. Toxicology Letters, 2020, In press. （SCI大類二區）
2. Chen Zhang, Dong Li, Tingting Ge, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. Science of the Total Environment. 2020, 708:135084. (SCI大類一區, TOP期刊，當年IF 5.589)
3.Cong Yuan, Chen Zhang, Yongmei Qi, Dong Li, Yan Hu, Dejun Huang*, 2.2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicology and Environmental Safety. 2019 Dec 6;189:110042. doi: 10.1016/j.ecoenv.2019.110042 （SCI大類二區）
4. Xueyan Gu, Yongmei Qi*,Zengxiu Feng,Lin Ma, Ke Gao,Yingmei Zhang*, Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicology Letters, 2018, 291:92-100. （SCI大類二區）
5. Yongmei Qi, Qian Qiu, Xueyan Gu, Yihong Tian, Yingmei Zhang*, ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Scientific Reports, 2016, 6, 24700. （SCI大類二區）
6. Yongmei Qi, Yingmei Zhang*, Yingxia Liu, Wenya Zhang, Nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in Raji cells, Experimental and Toxicologic Pathology, 2013, 65 (1-2): 69-72.
7. Yongmei Qi, Ailing Li, Dejun Huang, Yihong Tian, Yingmei Zhang*, Exogenous S-adenosyl-L-methionine could inhibit c-myc overexpression induced by As2O3 in normal human liver HL-7702 cells, Journal of Health Science, 2011, 57(2): 188-191.
8. Yongmei Qi, Norberta W Schoene, Frederick M Lartey, Wen-Hsing Cheng*, Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells, The Journal of Biological Chemistry, 2010, 285(43): 33010–33017.（SCI大類二區）
9. Dejun Huang*, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2018. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ Mol Mutagen. 59, 798-804. (SCI大類二區)
10. Tingting Ge, Jiangyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. 2017. The toxic effects of chlorophenols and associated mechanisms in fish. Aquatic Toxicology. 184, 78-93. (SCI大類二區，Top期刊)
11. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*, ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain, Neurotoxicology, 2015, 46:19-24.
12. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*, Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway, Toxicology Mechanisms and Methods, 2014, 24(7):504-511.
13. Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhang*, EGCG inhibits Cd-induced apoptosis through scavenging ROS rather than chelating Cd in HL-7702 cells, Toxicology Mechanisms and Methods, 2014, 24(4): 259-267.
14. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2a dephosphorylation in vitro, Environmental Toxicology, 2016, 31(2): 245-255.
15. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*, Cadmium delays non-homologous end joining (NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation ofXRCC4 and Ligase IV, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015, 779: 112-123. （SCI大類二區）
16. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis, International Journal of Toxicology, 2014, 33(6): 532-541.
17. Xiaoning Zhang, Hui Li, Qian Qiu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus, Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 2013, 160C: 54-59.
18. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway, Aquatic Toxicology, 2013, 140-141: 117-122.（SCI大類二區）
19. Peng Chen, Yingxia Liu, Yanqing Sun, Che Chen, Yongmei Qi, Yingmei Zhang*, AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression, Pharmacology Biology, 2013, 51(12):1586-1591.
