毛世瑞

毛世瑞 女,天津人,瀋陽藥科大學藥學院藥劑系藥劑教研室副主任,教授毛世瑞,博士生導師。

基本介紹

主要經歷,兼職情況,科研及獲獎,教學及指導研究生,論文著作,

主要經歷

1987-1991 瀋陽藥科大學獲理學學士學位
1991-1994 瀋陽藥科大學獲藥劑學碩士學位
1994- 至今 瀋陽藥科大學藥學院藥劑教研室助教、講師、副教授、教授
2002-2004 德國馬爾堡大學獲理學博士學位
2005-2006 德國馬爾堡大學博士後研究

兼職情況

亞洲藥物製劑科學雜誌(Asian Journal of Pharmaceutical Sciences)主編助理
國際緩控釋協會(CRS) 高級會員(Fellow of CRS)
中國顆粒學會顆粒製備與處理專業委員會委員
國際22個雜誌,國內8個雜誌的特約審稿人

科研及獲獎

主要研究方向:
1.生物可降解高分子聚合物作為藥物載體的研究
2.黏膜給藥系統(鼻、肺等)的研究
3.微納米給藥系統的研究
主要科研項目:
1. 國際科技部中泰合作項目“聚合物納米複合物的結構特性與大分子藥物胃腸吸收”, 項目負責人, 2010.1-2012.6
2.中美國際合作項目“套用納米技術提高難溶性藥物的生物利用度”,項目負責人, 2009-2011
3. 國家中醫藥管理局回國留學人員科技活動擇優資助課題, “長效注射PLGA微球的釋藥特性和影響藥物體內分布的因素”, 項目負責人,2008.3-2010.2
4. 國家教育部回國人員科研啟動基金,“低分子肝素/殼聚糖及其衍生物的納米複合物口服吸收”,項目負責人,2008.2-2010.2
5.參與國家科技部973重大科學研究計畫項目“納米技術改善難溶性藥物功效的套用基礎研究”(2009CB903302), 學術骨幹,2009, 1—2013, 1.
6.瀋陽藥科大學回國基金課題“胰島素殼聚糖納米複合物的研究”,項目負責人,2006-2007
7. 國家雙語教學示範課程-藥劑學建設項目國家雙語教學示範課程-藥劑學建設項目, 項目負責人,2010
主要獲獎和成果:
1.獲得由國際緩控釋協會授予的CRS-Nagai Postdoctoral Research Achievement Award,2009.
2.Journal of controlled release 十大審稿人(top reviewer) (2006,2007,2008)
3. 遼寧省自然科學學術成果一等獎(2011):
4. 遼寧省自然科學學術成果一等獎(2010)
5. 遼寧省百千萬人才千人層次, 2009
6. 2009年度ISP-瀋陽藥科大學Hulmut Award.
7. 2007-2008年度瀋陽藥科大學優秀教師
8. 瀋陽藥科大學優秀碩士畢業論文指導教師(2008, 2009,2010年度)
9. 瀋陽藥科大學優秀本科畢業論文指導教師(2007,2008, 2009年度)
10. 瀋陽藥科大學藥學院教學改革獎(2007)
11. 2002-2004年度德意志學術交流中心(DAAD)獎學金
教學/指導研究生情況:
國家雙語教學示範課程藥劑學課程負責人,講授本科生課程:藥劑學I,藥劑學III, 藥劑學實驗, 用英文授課.
指導碩士研究生15名(其中畢業 7名), 博士研究生4名 (其中畢業1名)
發表論文/出版著作:
代表性著作:
1. 學術專著“CHITOSAN COPOLYMERS FOR INTRANASAL DELIVERY OF INSULIN”, Der ander Verlag, Germany, 2004. 11.
2. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley Press. 2009. 編者, 第三章
3. 藥劑學實驗講義(英文版)瀋陽藥科大學 2009.2. 主編
4. 《經皮給藥新劑型》人民衛生出版社 2006.12. 編者
5. 《藥物粉體壓縮技術》化學工業出版社,2008.4. 譯者
6. 面向21世紀課程教材《藥劑學》,中國醫藥科技出版, 2002. 8,編者

教學及指導研究生

國家雙語教學示範課程藥劑學課程負責人,講授本科生課程:藥劑學I,藥劑學III, 藥劑學實驗, 用英文授課.
指導碩士研究生15名(其中畢業7名), 博士研究生4名(其中畢業1名)

論文著作

代表性著作:
1. 學術專著“CHITOSAN COPOLYMERS FOR INTRANASAL DELIVERY OF INSULIN”, Der ander Verlag, Germany, 2004. 11.
2. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley Press. 2009. 編者, 第三章
3. 藥劑學實驗講義(英文版)瀋陽藥科大學2009.2. 主編
4. 《經皮給藥新劑型》人民衛生出版社2006.12. 編者
5. 《藥物粉體壓縮技術》化學工業出版社,2008.4. 譯者
6.面向21世紀課程教材《藥劑學》,中國醫藥科技出版, 2002. 8,編者
代表性論文:
已在國內外學術期刊發表研究論文60餘篇,其中SCI收載29篇, 被引用近500次。代表性論文如下:
1. 毛世瑞* 田野王琳琳. 藥物納米載體-聚合物膠束的研究進展. 瀋陽藥科大學學報,2010,27(12), 979-986.
2. 王彥君,毛世瑞*,孫偉, 王娟,那立東,張婷婷. 白藜蘆醇PLGA長效注射微球的製備及影響因素研究. 瀋陽藥科大學學報2010, 27(4), 265-272.
3. 梅丹,毛世瑞*. 環糊精及其衍生物對磷酸川芎嗪鼻黏膜吸收的促進作用. 瀋陽藥科大學學報2008,25(12),933-938.
4. 毛世瑞, 李茗, 畢殿洲. 硫酸沙丁胺醇油包水型口服納米乳的製備及小腸吸收考察. 瀋陽藥科大學學報, 2005,22(6), 401-404.
5. 毛世瑞, 劉歡, 陳建明, 魏振平, 畢殿洲. 褪黑激素鼻腔給藥澱粉微球的製備工藝.瀋陽藥科大學學報, 2004, 21(5),324-327.
6. 毛世瑞, 紀宏宇, 畢殿洲. 微乳化技術製備固體脂質納米粒. 藥學學報, 2003, 38(8), 624-626.代表性論文:
已在國內外學術期刊發表研究論文60餘篇,其中SCI收載29篇, 被引用近500次。
代表性論文如下:
1. Sun Wei, Tian Wei, Zhang Yuyang, He Jianyong, Mao Shirui *, Fang Liang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanomedicine: NBM. 2011. ( in press)
2. Mao Shirui*, Zhang Tingting, Sun Wei, Ren Xuhong. The Depolymerization of Sodium Alginate by Oxidative Degradation. Pharm Dev Tech 2011 (in press)
3. Sun Wei, Mao Shirui *, Shi Yi, Li Chiu Luk, Fang Liang. Nanonization of Itraconazole by High Pressure Homogenization: S tabilizer Optimization and Effect of Particle Size on Oral Absorption. Journal of Pharmaceutical Sciences, 2011,100, 3365-3373
4. 毛世瑞* 田野 王琳琳. 藥物納米載體-聚合物膠束的研究進展. 瀋陽藥科大學學報, 2010,27(12), 979-986.
5. 王彥君,毛世瑞*,孫偉, 王娟,那立東,張婷婷. 白藜蘆醇PLGA長效注射微球的製備及影響因素研究. 瀋陽藥科大學學報 2010, 27(4), 265-272.
6. Na Lidong, Mao Shirui* ,Wang Juan, Sun Wei. Comparison of different absorption enhancers on the intranasal absorption of isosorbide dinitrate in rats. Int J Pharm 2010, 397(1-2), 59-66.
7. Duan Xiaopin, Mao Shirui*. New strategies to improve the intranasal absorption of insulin. Drug Discovery Today, 2010, 15(11-12), 416-427.
8. Zhang Tingting, Mao Shirui*, Sun Wei. Design and in vitro evaluation of a film-controlled dosage form self-converted from monolithic tablet in gastrointestinal environment. Journal of Pharmaceutical Sciences, 2010, 99(11), 4678-4690.
9. Sun Wei, Mao Shirui*, Wang Yanjun, Junyaprasert VB, Zhang Tingting, Na Lidong, Wang Juan. Bioadhesion and oral absorption of enoxaparin nanocomplexes. Int J Pharm 2010, 386, 275-281.
10. Mao Shirui*, Sun Wei, Kissel T. Chitosan based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 2010,62(1),12-27.
11. Zhao Ruizhi, Liu Shaojun, Mao Shirui, Wang Yanjun. Study on liver targeting effect of vinegar-baked Radix Bupleuri on resveratrol in mice, Journal of ethnopharmology, 2009, 126,415-420
12. Mei Dan, Mao Shirui*, Sun Wei, Kissel T. Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats. Eur J Pharm Biopharm. 2008, 70(3), 874-881.
13. Sun Wei, Mao Shirui*, Mei Dan and Kissel T. Self-Assembled Polyelectrolyte Nanocomplexes between Chitosan Derivatives and Enoxaparin. Eur J Pharm Biopharm. 2008 ,69(2),417-425.
14. Mao Shirui, Shi Y, Li L, Xu J, Schaper A, Kissel T. Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm. 2008,68,214-223.
15. Germershaus O, Mao Shirui, Sitterberg J, Bakowsky U, Kissel T. Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure-activity relationships in vitro. J Control Release 2008,125(2):145-154.
16. Jintapattanakit A., Mao Shirui, Kissel T., V. B. Junyaprasert. Physicochemical Properties and Biocompatibility of N-Trimethyl Chitosan: Effect of Quaternization and Dimethylation. Eur. J. Pharm.Biopharm, 2008 Oct;70(2):563-571.
17. 梅丹,毛世瑞*. 環糊精及其衍生物對磷酸川芎嗪鼻黏膜吸收的促進作用. 瀋陽藥科大學學報 2008,25(12),933-938.
18. Mao Shirui, Xu Jing, Cai Cuifang, Germershaus Oliver, Schaper Andreas, Kissel Thomas. Effect of WOW process parameters on morphology of FITC-dextran loaded PLGA microspheres. Int. J. Pharm. 2007,334, 137-148.
19. Mao Shirui, Augsten C, Maeder K, Kissel. T.Characterization of chitosan and its derivatives using asymmetrical flow field-flow-fractionation: A comparison with traditional methods. J Pharm Biomed Anal 2007, 45(5),736-741.20. Mao Shirui, Neu M., Germershaus O., Merkel O., Sitterberg J., Bakowsky U., and Kissel T. Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes. Bioconjugate Chem., 2006,17 (5), 1209 -1218.
21. Mao Shirui, Bakowsky U., Jintapattanakit A., Kissel T. Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci 2006, 95(5), 1036-1048
22. Mao Shirui, Yang Shiling, Bi Dianzhou. Pharmacodynamics and potential toxicity of intranasally administrated dipyrone. Biol. Pharm. Bull 2006,29(7), 1355-1359.
23. Mao Shirui, Shuai Xintao, Unger F., Wittmar M., Xie Xiulan and Kissel T. Synthesis, characterization and cytotoxicity of poly (ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials. 2005, 26(32),6343-6356.
24. Mao Shirui, Germershaus O., Fischer D., Linn T., Schnepf R., Kissel T. Uptake and transport of self-assembled PEGylated trimethyl chitosan block copolymer-insulin nanocomplexes in Caco-2 cell monolayers. Pharm. Res. 2005, 22(12), 2058-2068.
25. Mao Shirui, Wang Pu, Bi Dianzhou. Investigations on 5-Fu solid lipid nanoparticles prepared by hot homogenization. Die Pharmazie 2005, 60(4), 273-277.
26. Mao Shirui, Shuai Xintao, Unger Florian, Simon Michael, Bi Dianzhou, and Kissel Thomas. The depolymerization of chitosan: Effects on physicochemical and biological properties, Int J Pharm 2004, 281, 45-54.
27. Mao Shirui, Chen Jianming, Liu Huan, Wei Zhenping, Bi Dianzhou. Intranasal administration of melatonin starch microsphere, Int J Pharm, 2004, 272(1-2), 37-43.
28. 毛世瑞, 李茗, 畢殿洲. 硫酸沙丁胺醇油包水型口服納米乳的製備及小腸吸收考察. 瀋陽藥科大學學報, 2005,22(6), 401-404.
29. 毛世瑞, 劉歡, 陳建明, 魏振平, 畢殿洲. 褪黑激素鼻腔給藥澱粉微球的製備工藝.瀋陽藥科大學學報, 2004, 21(5),324-327.
30. 毛世瑞, 紀宏宇, 畢殿洲. 微乳化技術製備固體脂質納米粒. 藥學學報, 2003, 38(8), 624-626.
國際學術交流:
Invited lectures:大會特邀報告:
1. Mao Shirui, Wang Juan. Polymeric micelles as carriers for peroral administration of hydroxycamptothecin.( Invited paper) Particles 2010, May 2010, Orlando, USA
2. Mao Shirui. Polymeric nanoparticles as carriers of drug delivery system. APSTJ Global Education Seminar East 2009-03. 2009 Oct 5, Tokyo, Japan.
3. Mao Shirui, Kissel T. Polyethylene glycol chain length influences the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/siRNA polyplexes. International Conference of The Korean Society of Pharmaceutical Sciences and Technology. November 22-23, 2007, Seoul, Korea.
Oral presentations大會報告:
1. Mao Shirui, Sun Wei, Fang Liang. The second Asian Symposium on Pharmaceutical Sciences and Technology, Sep 19-20, 2011, Xi’an, China.
2. Wang Yanjun, Mao Shirui*. Effect of particle size on the in vitro-in vivo release of resveratrol from PLGA microspheres. 17th International Symposium on Microencapsulation, 2009 Sep 29-Oct 1, Nagoya, Japan.
3. Mao Shirui, Sun Wei. Chitosan and its derivatives as the carriers for peroral administration of enoxaparin. Intervarsity Symposium 2008 National University of Singapore (NUS), Shenyang Pharmaceutical University (SPU), Prince of Songkla University (PSU) November 6, 2008. Venue: National University of Singapore.
4. Mao Shirui, Shi Yi, Li Luk, et al. Effects of process parameters on characteristis and internal morphology of poly(D,L-lactide-co-glycolide) microspheres formed by solvent evaporation method. The first Asian Symposium on Pharmaceutical Sciences and Technology, July 28-30, 2007, Shenyang, China.
5. Mao Shirui, Neu Michael, Germershaus Oliver, Merkel Olivia, Sitterberg Johannes, Bakowsky Udo, and Kissel Thomas. Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes. CRS Meeting in Jena, March 2006, Germany.
6. Mao Shirui, Germershaus Oliver, Fischer Dagmar, Kissel Thomas. Uptake and transport of PEG-graft-trimethyl chitosan block copolymer-insulin nanoparticles in Caco-2 cell monolayers. CRS Meeting in Marburg, March 2005, Germany.

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