段金友

段金友，男，1974年11月生，安徽宿松人，博士，西北農林科技大學教授，博士生導師，入選陝西省‘百人計畫’、教育部‘新世紀優秀人才支持計畫’。

基本介紹

• 中文名：段金友 
• 出生地：安徽宿松
• 出生日期：1974年11月 
• 職業：教師
• 畢業院校：中國科學院
• 學位/學歷：博士
• 專業方向：多糖免疫學
• 任職院校：西北農林科技大學

人物經歷

1997年獲得安徽師範大學學士學位，2000年獲得廣西大學碩士學位，2003年獲得中國科學院上海藥物研究所博士學位。2003年11月至2005年2月在美國約翰·霍普金斯大學從事糖脂功能博士後研究；2005年2月至2010年4月在美國哈佛大學醫學院從事多糖免疫學博士後研究,並於2010年5月晉升為講師；2010年7月聘為西北農林科大套用化學系教授、博士生導師。

學術兼職

第五屆中國生物化學與分子生物學會複合糖專業委員會委員、陝西省藥學會理事、陝西省藥學會藥物化學專委會委員。

國際期刊“Journal of Pharmacy and Pharmacology”、“Therapeutics and Clinical Risk Management”等雜誌的審稿人。

研究方向

多（寡）糖生物學：

1）天然多（寡）糖的功能機制：抗腫瘤、抗肥胖及腸道菌群調控等

2）基於多（寡）糖的藥物構建及套用

開設課程

《有機化學》、《藥物化學》、《糖生物學》、《酶學工程》

科研項目

省部級以上科研項目

國家自然科學基金面上項目（NSFC31870799）

國家自然科學基金面上項目（NSFC31570799）

國家自然科學基金面上項目（NSFC31270860）

教育部新世紀人才支持計畫（NCET-13-0480）

上海中醫藥大學合作項目（K332021201）.

學術論文

Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin. Qiu Y, Lu C, Chen P, Sun F, Wang D, Wang Z, Hou C, Mu H, Duan J. Carbohydr Polym . 2019 Apr 15;210:364-371.

Protein-Bound β-glucan from Coriolus Versicolor has Potential for Use Against Obesity. Li X, Chen P, Zhang P, Chang Y, Cui M, Duan J. Mol Nutr Food Res . 2019 Jan 22:e1801231. doi: 10.1002/mnfr.201801231.

A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy. Sun F, Zhang P, Liu Y, Lu C, Qiu Y, Mu H, Duan J.Carbohydr Polym. 2019 Feb 15;206:309-318.

Light controllable chitosan micelles with ROS generation and essential oil release for the treatment of bacterial biofilm.Wang Z, Bai H, Lu C, Hou C, Qiu Y, Zhang P, Duan J, Mu H. Carbohydr Polym . 2019 Feb 1;205:533-539.

Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (Schw.) Wolf. Zhang W, Chen L, Li P, Zhao J, Duan J. Int J Biol Macromol . 2018 Dec;120(Pt B):1696-1704.

Sulfated modification and biological activities of polysaccharides derived from Zizyphus jujuba cv. Jinchangzao. Cai Y, Chen P, Wu C, Duan J, Bai H. Int J Biol Macromol . 2018 Dec;120(Pt A):1149-1155.

A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy. Hou C, Bai H, Wang Z, Qiu Y, Kong LL, Sun F, Wang D, Yin H, Zhang X, Mu H, Duan J. Carbohydr Polym . 2018 Sep 1;195:339-348.

Inulin based glutathione-responsive delivery system for colon cancer treatment. Wang D, Sun F, Lu C, Chen P, Wang Z, Qiu Y, Mu H, Miao Z, Duan J. Int J Biol Macromol . 2018 May;111:1264-1272.

A novel photocleavable heparin derivative with light controllable anticoagulant activity. Sun F, Liu Y, Wang D, Wang Z, Mu H, Wang F, Ding K, Duan J. Carbohydr Polym . 2018 Mar 15;184:191-198.

Synthesis of hyaluronan-amikacin conjugate and its bactericidal activity against intracellular bacteria in vitro and in vivo. Wang Z, Qiu Y, Hou C, Wang D, Sun F, Li X, Wang F, Yi H, Mu H, Duan J. Carbohydr Polym . 2018 Feb 1;181:132-140.

Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity. Qiu Y, Hou Y, Sun F, Chen P, Wang D, Mu H, Zhang X, Ding K, Duan J. Glycobiology . 2017 Sep 1;27(9):861-867.

Novel moisture-preserving derivatives of hyaluronan resistant to hyaluronidase and protective to UV light. Sun F, Niu H, Wang D, Wu Y, Mu H, Ma L, Duan J. Carbohydr Polym . 2017 Feb 10;157:1198-1204.

Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan. Wang D, DanXu, Sun Y, Wu Y, Ma L, Duan J. Glycoconj J . 2017 Feb;34(1):3-12.

A tanshinone I derivative enhances the activities of antibiotics against Staphylococcus aureus invitro and invivo. Wang D, Lu C, Sun F, Cui M, Mu H, Duan J, Geng H. Res Microbiol . 2017 Jan;168(1):46-54.

Chitosan conjugation enables intracellular bacteria susceptible to aminoglycoside antibiotic.

Mu H, Niu H, Wang D, Sun F, Sun Y, Duan J. Glycobiology . 2016 Nov;26(11):1190-1197.

Preparation and sulfation of an α-glucan from Actinidia chinensis roots and their potential activities. Niu H, Song D, Sun Y, Zhang W, Mu H, Duan J. Int J Biol Macromol . 2016 Nov;92:981-987.

Autophagy promotes DNA-protein crosslink clearance. Mu H, Liu Q, Niu H, Wang D, Tang J, Duan J. Mutat Res Genet Toxicol Environ Mutagen . 2016 Feb;797:21-5.

Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus. Niu H, Song D, Mu H, Zhang W, Sun F, Duan J. Int J Biol Macromol . 2016 May;86:587-93.

Novel pH-sensitive polysialic acid based polymeric micelles for triggered intracellular release of hydrophobic drug. Zhang W, Dong D, Li P, Wang D, Mu H, Niu H, Duan J. Carbohydr Polym . 2016 Mar 30;139:75-81.

Structural characterization and biological activities of two α-glucans from radix paeoniae alba. Zhang W, Li P, Song D, Niu H, Shi S, Wang S, Duan J. Glycoconj J . 2016 Apr;33(2):147-57.

Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria. Mu H, Tang J, Liu Q, Sun C, Wang T, Duan J. Sci Rep. 2016 Jan 5;6:18877. doi: 10.1038/srep18877.

Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii. Zhang W, Song D, Xu D, Wang T, Chen L, Duan J. Carbohydr Polym . 2015 Nov 20;133:154-62.

Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives. Wang D, Zhang W, Wang T, Li N, Mu H, Zhang J, Duan J. Int J Mol Sci . 2015 Jul 31;16(8):17668-81.

Mechanistic insights into cellular immunity of chondroitin sulfate A and its zwitterionic N-deacetylated derivatives. Zhang W, Sun F, Niu H, Wang Q, Duan J. Carbohydr Polym . 2015 Jun 5;123:331-8.

Characterization of two water-soluble lignin metabolites with antiproliferative activities from Inonotus obliquus. Wang Q, Mu H, Zhang L, Dong D, Zhang W, Duan J. Int J Biol Macromol . 2015 Mar;74:507-14.

Chitosan improves anti-biofilm efficacy of gentamicin through facilitating antibiotic penetration. Mu H, Guo F, Niu H, Liu Q, Wang S, Duan J. Int J Mol Sci . 2014 Dec 3;15(12):22296-308.

Purification, antioxidant and immunological activities of polysaccharides from Actinidia Chinensis roots. Zhang L, Zhang W, Wang Q, Wang D, Dong D, Mu H, Ye XS, Duan J. Int J Biol Macromol . 2015 Jan;72:975-83.

Alteration in immune responses toward N-deacetylation of hyaluronic acid. Zhang W, Mu H, Dong D, Wang D, Zhang A, Duan J. Glycobiology . 2014 Dec;24(12):1334-42.

Extraction optimization, characterization and immunity activity of polysaccharides from Fructus Jujubae. Cui G, Zhang W, Wang Q, Zhang A, Mu H, Bai H, Duan J. Carbohydr Polym . 2014 Oct 13;111:245-55.