楊志謀，男，博士，南開大學生命科學學院生物化學和分子生物學系教授、博士生導師。主要從事小分子水凝膠的製備及其在組織工程、藥物釋放、癌症治療等領域的套用。
基本介紹
- 中文名：楊志謀
- 國籍：中國
- 民族：漢
- 職業：教授、博士生導師
人物經歷,人物榮譽,研究方向,主要論著,主要學術論文,
人物經歷
1997.9-2001.7 南京大學高分子系 學士
2001.7-2002.12 南京大學高分子系 科研助手（臨時）
2003.2-2006.8 香港科技大學化學系 博士
2006.8-2007.3 香港科技大學化學系 博士後
2007.3-2008.12 史丹福大學微生物與病原體系 博士後
2009.3至今 南開大學, 教授, 博士生導師
人物榮譽
2018年8月3日，根據《國家傑出青年科學基金項目管理辦法》的有關規定，國家自然科學基金委員會將2018年度國家傑出青年科學基金建議資助項目申請人名單予以公布，楊志謀在名單之中。
研究方向
1）基於抗癌藥物的小分子水凝膠；
2）短肽小分子水凝膠體內外生物相容性評價；
3）小分子水凝膠對幹細胞分化的調控；
4）基於蛋白-多肽特異性結合的水凝膠；
5）短肽水凝膠的可控制備及生物醫療套用。
主要論著
12. Wang, H. M.~; Wei, J.~; Yang, C. B.; Zhao, H. Y.; Li, D. X.; Yin, Z. N.; and Yang, Z. M.* "The Inhibition of Tumor Growth and Metastasis by Self-assembled Nanofibers of Taxol" Biomaterials, 2012, in press.( ~equal contributions)
11. Zhang, X. L.; Chu, X. L.; Wang, L.; Wang, H. M.; Liang, G. L.; Zhang, J. X.; Long, J. F.*; and Yang, Z. M.* "Rational Design of A Tetrameric Protein to Enhance Interactions Between Self-assembled Fibers Gives Molecular Hydrogels" Angew. Chem. Int. Ed., 2012, 51, 1-6.
10. Wang, H. M. and Yang, Z. M.* "Molecular hydrogels of hydrophobic compounds: a novel self-delivery system for chemotherapy", Soft Matter, 2012, 8, 2344-2347. (Invited Highlight)
9. Mao, L. N,; Wang, H. M.; Tan, M.; Ou, L. L.; Kong, D. L. and Yang, Z. M.* "Conjugation of Two Complementary Anti-Cancer Drugs Confers Molecular Hydrogels as A Co-delivery System", Chem. Commun. 2011, 48(3), 395-397.
8. Wang, Z. H.; Zheng, W. T.; Wang, H. M.; Wang, S. F.; Zhao, Q.; Zhang, J.; Yang, Z. M.* ; Kong, D. L.* "Highly stable surface modification of PCL by molecular self-assembly of a gelator" Chem. Commun., 2011, 47 (31), 8907-8903.
7. Liu, H. J.~; Hu, Y. H.~; Wang, H. M.; Wang, J. Y.; Wang, L.; Kong, D. L.; Chen, L. Y.*; Yang, Z. M.* "A thixotropic molecular hydrogel selectively enhances Flk1 expression in differentiated murine embryonic stem cells" Soft Matter, 2011, 7, 5430-5436. ( ~equal contributions , selected as a 'hot article').
6. Wang, H. M.; Yang, C. H.; Wang, L.; Kong, D. L.; Yang, Z. M.* " Self-assembled Nanospheres as a Novel Delivery System for Taxol: A Molecular Hydrogel with Nanosphere Morphology" Chem. Commun., 2011, 47 (15), 4439-4441.
5. Wang, H. M.; Yang, C. H.; Tan, M.; Wang, L.; Kong, D. L.; Yang, Z. M.* "A structure-gelation ability study in a short-peptide based 'super gelator' system" Soft Matter, 2011, 7 (8), 3897 - 3905.
4. Ren, C. H.; Song, Z. J.; Zheng, W. T.; Wang, L.; Kong, D. L.; Yang, Z. M.* "Disulfide bond as a cleavable linker for molecular self-assembly and hydrogelation" Chem. Commun., 2011, 47, 1619-1621.
3. Wang, H. M.; Wang, Z.; Yi, X. Y.; Long, J. F.; Liu, J. F.; Yang, Z. M.* "Anti-degradation of a recombinant complex protein by incorporation in small molecular hydrogels" Chem. Commun., 2011, 47, 955-957.
2. Wang, J. Y.; Wang, Z. H.; Wang, L.;* Yang, Z. Y.; Kong, D. L.;* and Yang, Z. M.* "Incorporation of Supramolecular Hydrogels into Agarose Hydrogels Affords Novel Materials as Potential Drug Delivery Carriers" J. Mater. Chem., 2009, 19, 7892-7896.
1. Gao, J.; Wang, H. M.; Wang, L.;* Wang, J. Y.; Kong, D. L.;* and Yang, Z. M.* "Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule" J. Am. Chem. Soc. 2009, 131, 11286-11287.
主要學術論文
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Jie Gao, Huaimin Wang, Ling Wang*, Jingyu Wang, Deling Kong*, and Zhimou Yang*. Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule. J. Am. Chem. Soc. 2009-7-24
Zhang, X. L.; Chu, X. L.; Wang, L.; Wang, H. M.; Liang, G. L.; Zhang, J. X.; Long, J. F.* and Yang, Z. M.*. Rational Design of a Tetrameric Protein to Enhance Interactions between Self-Assembled Fibers Gives . Angew. Chem. Int. Ed. 51--1-6. 2012-3-23
Zheng WT, Wang ZH, Song LJ, Zhao Q*, Zhang J, Li D, Wang SF, Zheng XL, Han JH, Yang ZM, Kong DL*. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery mode. Biomaterials 33-10-2880-2891. 2012-4-1
Huaimin Wang, Jun Wei, Chengbiao Yang, Huiyuan Zhao, Dongxia Li, Zhinan Yin, and Zhimou Yang*. The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol. Biomaterials 2012-5-5
Wang, H. M.; Shi, Y.; Wang, L.; and Yang, Z. M.*. Recombinant Proteins as Cross-linkers for Hydrogelations. Chem. Soc. Rev. --. 2012-11-20
Zheng, W. T.; Gao, J.; Song, L. J.; Chen, C. Y.; Guan, D.; Wang, Z. H.; Li, Z. B.*; Kong, D. L.*; and Yang, Z. M.*. Surface-induced hydrogelation inhibits platelets aggregation. J. Am. Chem. Soc. --. 2012-12-14
