林自力

林自力，女，北京農學院副教授 。2007年獲山東農業大學學士學位；2010年獲北京農學院碩士學位；2016年獲韓國國立忠北大學博士學位；2016年-2019年在清華大學從事博士後研究，2019年在清華大學被聘為副研究員；2021年2月至今在北京農學院工作。

基本介紹

• 中文名：林自力
• 國籍：中國
• 民族：漢
• 學位/學歷：博士
• 職務：副教授

人物經歷

2007年獲山東農業大學學士學位

2010年獲北京農學院碩士學位

2016年獲韓國國立忠北大學博士學位

2016年-2019年在清華大學從事博士後研究

2019年在清華大學被聘為副研究員

2021年2月至今在北京農學院工作

研究方向

動物生殖生理與繁殖研究。

代表性論文

1. Wu JY#, Xu JW#, Liu BF#, Yao GD#, Wang PZ#, Lin ZL#, Huang B, Wang XP, Li T, Shi SL, Zhang N, Duan FY, Ming J, Zhang XY, Niu WB, Song WY, Jin HX, Guo YH, Dai SJ, Hu LL, Fang LL, Wang QJ, Li YY, Li W, Na J, Xie W, Sun YP. Chromatin Analysis in Human Early Development Reveals Epigenetic Transition During ZGA. Nature. 2018; 557: 256–260. (#Co-first author). IF=69.5.

2. Xiong ZQ#, Xu K#, Lin ZL#, Kong F#, Wang QJ#, Quan YJ#, Sha QQ, Li FJ, Li L, Xie W. Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and early development, NAT CELL BIOL. 2022; 24, 968–980. (#Co-first author). IF=29.

3. Lin ZL, Xu YN, Namgoong S, Kim NH. JMY Functions as Actin Nucleation-Promoting Factor and Mediator for p53-Mediated DNA Damage in Porcine Oocytes. PLOS ONE. 2014; 9(10): e109385.

4. Lin ZL, Ni HM, Liu YH, Sheng XH, Cui XS, Kim NH, Guo Y. Effect of anti-PMSG on Distribution of Estrogen Receptor Alpha and Progesterone Receptor in Mouse Ovary, Oviduct and Uterus. Zygote. 2015; 23(5):695-703.

5. Lin ZL, Li YH, Xu YN, Wang QL, Namgoong S, Cui XS, Kim NH. Effects of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 on the in Vitro Maturation of Porcine oocytes. Reprod Domest Anim. 2014; 49(2):219-27.

6. Lin ZL, Kim NH. Role of Ataxia-Telangiectasia Mutated (ATM) in Porcine Oocyte in vitro Maturation. Cell Biol Int. 2015; 17; 39(6):710-20.

7. Lin ZL, Cui XS, Namgoong S, Kim NH. Junction-mediating and regulatory protein (JMY) is Essential for Early Porcine Embryonic Development. J Reprod Dev. 2015; 61(5):361-7.

8. Lin ZL, Li YH, Jin YX, Kim NH. A Maternal Transcription Factor, Junction Mediating and Regulatory Protein is Required for Preimplantation Development in the Mouse. Dev Reprod. 2019 23(3), 285-295.

9. Ji SY, Chen FL, Stein P, Wang JC, Zhou ZM, Wang LJ, Zhao Q, Lin ZL, Liu BF, Schultz RM, Xie W. OBOX regulates murine zygotic genome activation and early development. Nature. 20230717.

10. Lu XK #, Zhang Y#, Wang LJ#, Wang LY#, Wang H, Xu Q, Xiang Y, Chen C, Kong F, Xia W, Lin ZL, Ma S, Liu L, Wang X, Ni H, Li W, Guo Y, Xie W. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances. 2021 Nov 26;7(48): eabi6178.

11. Zhang K #, Wu DY #, Zheng H #, Wang Y #, Sun QR, Liu X, Wang LY, Xiong WJ, Wang QJ, Rhodes J, Xu K, Li LJ, Lin ZL, Yu G, Xia WK, Huang B, Du ZH, Yao Y, Nasmyth KA, Klose RJ, Miao YL Xie W. Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA. Mol Cell. 2020. 79:234-250.

12. Liu BF #, Xu QH #, Wang QJ #, Feng S, Lai FN, Wang PZ, Zheng FY, Xiang YL, Wu JY, Nie JW, Qiu C, Xia WK, Li LJ, Yu G, Lin ZL, Xu K, Xiong ZQ, Kong F, Liu L, Huang CY, Yu Y, Na J, Xie W. The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature. 2020; 587, 139-144.

13. Jang WI, Lin ZL, Lee SH, Namgoong S, Kim NH. A Specific Inhibitor of CDK1, RO-3306, Reversibly Arrests Meiosis During in vitro Maturation of Porcine Oocytes. Anim Reprod Sci. 2014; 144 (3-4): 102-8.

14. Wang HY, Lin ZL, Yu XF, Cui XS, Kim NH. Computational Prediction of Alzheimer’s and Parkinson’s Disease microRNAs in Domestic Animals. Asian Australas. J. Anim. Sci. Search. 2016; 29(6):782-92.

15. Luo YB#, Zhang L#, Lin ZL, Ma JY, Jia J, Namgoong S, Sun QY. Distinct Subcellular Localization and Potential Role of LINE1-ORF1P in Meiotic Oocytes. Histochem Cell Biol. 2016;145(1):93-104.

16. Du ZH#, Zheng H#, Kawamura KK#, Zhang K#, Gassler J, Powell S, Xu QH, Lin ZL, Xu K, Zhou Q, Ozonv EA, Véron N, Huang B, Li LJ, Yu G, Liu L, Wang PZ, Chang L, Wang QJ, He AB, Sun YJ, Na J, Sun QY, Sasaki H, Tachibana K, Peters A, Xie W. (2020) Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Molecular Cell 77(1-15).

17. Xia WK#, Xu JW#, Yu G#, Yao GD#, Xu K,† Ma XS,† Zhang N,† Liu BF, Li T, Lin ZL, Chen X, Li LJ, Wang QJ, Shi DY,Shi SL, Zhang YL, Song WY, Jin HX, Hu LL, Xie W, Sun YP. (2019) Resetting Histone Modifications During Human Parental-to-zygotic Transition. Science. 2019; 26;365(6451):353-360.

18. Wang HY, Luo YB, Lin ZL, Cui XS, Kim NH. Effect of ATM and HDAC Inhibition on Etoposide-induced DNA Damage in Porcine Early Preimplantation Embryos. PLOS ONE. 2015 Nov 10;10(11): e0142561.

19. Wang HY, Guo J, Lin ZL, Namgoong S, Oh JS, Kim NH. Filamin A is required for spindle migration and asymmetric division in mouse oocytes. FASEB J. 2017 Aug;31(8):3677-3688.

20. Lee SK, Zhao MH, Kwon JW, Li YH, Lin ZL, Jin YX, Kim NH, Cui XS. The Association of Mitochondrial Potential and Copy Number with Pig Oocyte Maturation and Developmental Potential. J Reprod Dev. 2014; 60(2): 128-35.

21. Wang H, Luo Y, Zhao MH, Lin ZL, Kwon J, Cui XS, Kim NH. DNA Double-strand Breaks Disrupted the Spindle Assembly in Porcine Oocytes. Mol Reprod Dev. 2016; 83(2):132-43.

22. Lin ZL, Kwon JW, Kim NH. Effect of Recombinant Growth Differentiation Factor 9 (GDF 9) and Bone Morphogenetic Protein 15 (BMP 15) on MAPK and MPF Signals in Porcine Oocytes in vitro maturation. Bulletin of Animal Biotechnology. 2013 (5):44-51.

23. Lee SK, Zhao MH, Li YH, Lin ZL, Jin YX, Kim NH, Cui XS. Mitochondrial Membrane Potential is Critical to Porcine Oocyte Maturation in Vitro. Reproductive & Developmental Biology. 2013, 37(2):99-116.

24. 林自力,高雅,鄧桂馨,梁鴻斌,張鴻波,劉雲海,倪和民,郭勇,王志剛. PMSG 和 FSH 同期發情處理對小鼠子宮，卵巢和輸卵管中雌激素 α 受體分布的影響. 中國實驗動物學報［J］. 2010，18(3) :204-207.

25. 林自力, 倪和民, 郭勇, 梁鴻斌, 尹艷雲, 鄧桂馨, 劉雲海. PMSG 和 FSH 同期發情處理對小鼠卵巢，輸卵管和子宮中受體分布的影響. 中國比較醫學雜誌［J］. 2011,21(5): 11-14.

26. 林自力, 何艷芳, 盧婷婷, 康 蕊, 秦秀蕊, 張 鑫, 倪和民. 稀釋液中分別添加不同濃度咖啡因或谷胱甘肽對犬精液冷凍效果的影響. 中國農學通報［J］. 2010,26(8):21-24.

27. 高雅， 林自力， 張鴻波， 梁鴻斌， 劉雲海， 郭勇， 倪和民. 自然發情與誘導發情小鼠子宮內膜中雌激素受體 α 表達的比較. 中國實驗動物學報［J］. 2010,18(2):168-172 20.

國際專利

專利名稱：簡單易用的PAT實驗分析方法（韓國第10-2014-0049404 號）