杜世燊

杜世燊，武漢大學生命科學學院，研究員、博導。研究方向細菌細胞生長與分裂的機制。

基本介紹

• 中文名：杜世燊
• 畢業院校：武漢大學生命科學學院
• 學位/學歷：博士
• 專業方向：細菌細胞生長與分裂的機制
• 學科專業：微生物學

人物簡介

杜世燊，武漢大學生命科學學院，研究員、博導。

學習經歷

2003.9 — 2007.6　 武漢大學生命科學學院生命科學與技術基地班, 生物學學士

2007.8 — 2013.12　美國堪薩斯大學醫學中心，微生物學博士

工作經歷

2014.2 — 2018.6 堪薩斯大學醫學中心博士後

2018.7 — 2019.6 堪薩斯大學醫學中心研究助理教授

社會工作

PNAS, EMBO Report, Front Microbiol 和Cell Biosci等雜誌應邀審稿人

研究領域

遺傳學、生物化學以及細胞生物學等一系列手段研究elongasome和divisome的組裝和工作機理，對細菌基本生命活動的了解。

抑制它們的活性可以阻斷細胞壁合成從而可以殺死細菌。研究elongasome和dvisome合成細胞壁的機理，同時以複合體中的重要蛋白為靶點，研發抗菌藥物。

論文成果

1.Shishen Du, Wyatt Henke, Sebastien Pichoff, Joe Lutkenhaus*. (2019) How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.Mol Microbiol[Epub ahead of print]

2.Shishen Du, Joe Lutkenhaus*. (2019) At the heart of bacterial cytokinesis: the Z ring.Trends MicrobiolS0966-842X(19)30122-2

3.Qinggong Guo, Beibei Chen, Yishuai Tu,Shishen Du*, and Xiangdong Chen*. (2019) Prophage LambdaSo uses replication interference to suppress reproduction of co-existing temperate phage MuSo2 in Shewanella oneidensis MR-1.Environ Microbiol21(6)2079-2094

4.Yunqian Qiao, Jiao Wang, He Wang, Baozhong Chai, Chufeng Rao, Xiangdong Chen* andShishen Du*. (2018) 4-hydroxyphenylpyruvate dioxygenase thermolability is responsible for temperature-dependent melanogenesis in Aeromonas Salmonicida subsp. Salmonicida.Appl Environ Microbiol13; 85 (1). pii::e01926-18

5.Shishen Du, Sebastien Pichoff, Kruse K and Joe Lutkenahus. (2018) FtsZ filaments have the opposite kinetic polarity of microtubules.Proc Natl Acad Sci USA115(42):10768-10773 (Faculty of 1000)

6.Sebastien Pichoff#,Shishen Du# and Joe Lutkenhaus. (2018) Disruption of divisome assembly rescued by FtsN-FtsA interaction in E. coli.Proc Natl Acad Sci USA115(29):E6855-E6862 (#:equal contribution)

7.Kyung-Tae Park, Alex Dajkovic, Mark Wissel,Shishen Duand Joe Lutkenhaus*. (2018) MinC and FtsZ mutant analysis provides insight into MinC/MinD-mediated Z Ring disassembly.J Biol Chem.293(16)::5834-5846

8.Joe Lutkenhaus*, andShishen Du. (2017) E. coli Cell cycle Machinery.Subcell Biochem84: 27-65

9.Shishen Du, and Joe Lutkenhaus*. (2017) The N-succinyl-ll-diaminopimelic acid desuccinylase acts through ZapB to promote septum formation in Escherichia coli.Mol Microbiol105(2):326-345 (Faculty 1000)

10.Shishen Du, and Joe Lutkenhaus*. (2017) Assembly and activation of the Escherichia coli divisome.Mol Microbiol105(2):177-187

11.Shishen Du, Sebastien Pichoff, and Joe Lutkenhaus*. (2016) FtsEX acts on FtsA to regulate divisome assembly and activation in E. coli.Proc Natl Acad Sci USA113 (34):E5052-61(Faculty 1000)

12.Kyung-Tae Park,Shishen Du, and Joe Lutkenhaus*. (2015) MinC/MinD copolymers are not required for Min function.Mol Microbiol98 (5): 895-909

13.Sebastien Pichoff,Shishen Du, and Joe Lutkenhaus*. (2015) The bypass of ZipA by overexpression of FtsN requires a previously unknown conserved FtsN motif essential for FtsA-FtsN interaction supporting a model in which FtsA monomers recruit late cell division proteins to the Z ring.Mol Microbiol95 (6): 971-987

14.Shishen Du, Kyung-Tae Park, and Joe Lutkenhaus*. (2015) Oligomerization of FtsZ converts the FtsZ tail motif (Conserved carboxy-terminal peptide) into a multivalent ligand with high avidity for partners ZipA and SlmA.Mol Microbiol95 (2): 173-188

15.Shishen Du, and Joe Lutkenhaus*. (2014) SlmA antagonism of FtsZ ring assembly employs a two-pronged mechanism like MinCD.PloS Genetics10.1371-e1004460

16.Joe Lutkenhaus*, Sebastien Pichoff, andShishen Du. (2012) Bacterial cytokinesis: From Z ring to divisome.Cytoskeleton(Hoboken) 69: 778-790

17.Shishen Du, and Joe Lutkenhaus*. (2012) MipZ: One for the Pole, Two for the DNA.Molecular Cell46: 239-240