李沁桐

李沁桐，男，博士，美國愛荷華大學(University of Iowa)，四川大學生命科學學院副教授，博士生導師。

研究方向

李沁桐實驗室致力於幹細胞生物學研究及轉化醫學開發。利用iPS誘導幹細胞技術和幹細胞定向分化技術模擬人類疾病發生髮展過程，研究致病機理，開發幹細胞治療並為新藥研製提供篩選平台。

人物經歷

學位簡歷和工作簡歷

1. 2006年，University of Iowa (美國)，博士

2. 2007-2008，Harvard University (美國)，博士後

3. 2008-2009，University of California at San Francisco (美國)，博士後

4. 2009-至今，四川大學生長代謝衰老研究中心，生命科學學院，副教授，博士生導師

發表文章（影響因子為五年影響因子，來源於2012年JCR）

1. IGF-1 regulates the SIRT1-p53 pathway in cellular senescence.

Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX.

Aging Cell，2014，IF = 6.415。

2. Primordial dwarfism gene links Lin28 to safeguard embryonic stem cell from premature differentiation.

Dai Q, Luan G, Deng L, Lei T, Kang H, Song X, Zhang Y, Xiao ZX, Li Q.

Cell Reports，2014，Cell子刊。

3. PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM.

Nucleic Acids Research，2012 Oct;40(18):9160-70，IF = 8.055。

4. Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Song X, Li L, Li Q.

Journal of Biological Chemistry，2012 Jul 20;287(30):25344-52，IF = 5.023。

5. Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems.

Li Q, Peterlin BM.

Methods，2009 Aug;48(4):375-80，IF = 4.159。

6. Cyclin T2 is essential for mouse embryogenesis.

Kohoutek J, Li Q, Blazek D, Luo Z, Jiang H, Peterlin BM.

Molecular and Cellular Biology，2009 Jun;29(12):3280-5，IF = 5.745，共同第一作者。

7. Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transrciption. Gurumurthy M, Tan CH, Ng R, Zeiger L, Lau J, Lee J, Dey A, Philp R, Li Q, Lim TM, Price DH, Lane DP, Chao SH.

Journal of Molecular Biology，2008 Apr 25;378(2):302-17，IF = 3.888。

8. MicroRNA regulation of stem cell fate.

Li Q, Gregory RI.

Cell Stem Cell，2008 Mar 6;2(3):195-6，IF = 27.361。

9. Systematic analysis of the protein interaction network for the human transrciption machinery reveals the identity of the 7SK capping enzyme.

Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B.

Molecular Cell，2007 Jul 20;27(2):262-74，IF = 14.902，封面文章。

10. HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.

Li Q, Cooper JJ, Altwerger GH, Feldkamp MD, Shea MA, Price DH.

Nucleic Acids Research，2007;35(8):2503-12，IF = 8.055。

11. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.

Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH.

Journal of Biological Chemistry，2005 Aug 5;280(31):28819-26，IF = 5.023。

12. HEXIM2, a HEXIM1-related protein, regulates positive transrciption elongation factor b through association with 7SK.

Byers SA, Price JP, Cooper JJ,Li Q, Price DH.

Journal of Biological Chemistry，2005 Apr 22;280(16):16360-7，IF = 5.023。

13. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O.

EMBO Journal，2004 Jul 7;23(13):2608-19，IF = 9.602，共同第一作者。