李宏業，江蘇淮安人，男，教授，博士生導師，主要研究方向：1）海洋微藻生物技術；2）微藻脂類代謝機理及生物能源研發；3）微藻高附加值生物活性物質合成途徑；4）微藻藻華。圍繞微藻生物活性物質開展代謝機理的系列研究，包括功能基因組學及基因表達調控、高附加值生物活性物質及生物毒素的生物合成途徑、基於代謝工程及生物製造推動資源高值化利用。
基本介紹
- 中文名：李宏業
- 國籍：中國
- 民族：漢族
- 出生地：江蘇淮安
- 畢業院校：香港大學
人物經歷,研究方向,主要貢獻,
人物經歷
1993–1998，中科院華南植物園及微生物所，研究實習員、助理研究員；2003–2007，香港大學及香港中文大學，博士後研究員；2007–2008，香港大學生物科學學院，Croucher助理教授；2008.10起任職於暨南大學生命科學與技術學院，教授，博士生導師。
中國海洋湖沼學會海洋生物技術分會理事、中國藻業協會工作指導委員會委員、廣東省植物生理學會理事、Frontiers in Marine Science等期刊編委。
研究方向
1）海洋微藻生物技術；2）微藻脂類代謝機理及生物能源研發；3）微藻高附加值生物活性物質合成途徑；4）微藻藻華。
主要貢獻
近 5 年作為通訊作者及第一單位，在Science子刊Science Advances、Metabolic Engineering、Environmental Microbiology、Biotechnology for Biofuels、Marine Biotechnology 等重要SCI期刊發表論文30餘篇，其中SCI一區及二區期刊各12篇；獲授權專利5件；研究成果產生了廣泛影響，多篇論文被 ScienceDirect 等評為高閱讀量文章，入選 ESI 高被引論文。在主要國內外學術會議上做了多次主題報告。主持成果獲教育部高等學校科學研究優秀成果獎自然科學獎二等獎、廣東省第四屆南粵科技創新優秀學術論文一等獎、中國藻類學會優論文二等獎等獎項。
近期代表性論文如下：
Li DW, Balamurugan S, Yang YF, Zheng JW, Huang D, Zou LG, Yang WD, Liu JS, Guan YF, Li HY. Transcriptional regulation of microalgae for concurrent lipid overproduction and secretion. Science Advances. 2019, 5: eaau3795.
Wang X, Dong HP, Wei W, Balamurugan S, Yang WD, Liu JS, Li HY. Dual expression ofplastidial GPAT1 andLPAT1 regulates triacylglycerol production andthefatty acid profile inPhaeodactylum tricornutum. Biotechnology for Biofuels. 2018. 11:318.
Yang YF, Li DW, Chen TT, Hao TB, Balamurugan S, Yang WD, Liu JS, Li HY.Overproduction of Bioactive Algal Chrysolaminarin by the Critical Carbon Flux Regulator Phosphoglucomutase. Biotechnology Journal. 2018. e1800220.
Da-Wei Li, Wei-Hong Xie, Ting-Bin Hao, Jia-Xi Cai, Tian-Bao Zhou, Srinivasan Balamurugan, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li. Constitutive and Chloroplast Targeted Expression of Acetyl-CoA Carboxylase in Oleaginous Microalgae Elevates Fatty Acid Biosynthesis. Marine Biotechnology. 2018. 20(5): 566-572.
Wang X, Wei W, Li NJ, Yuan W, Ding Y, Yang WD, Liu JS, Balamurugan S, Li HY. Heterogeneous expression of human PNPLA3 triggers algal lipid accumulation and lipid droplet enlargement. Algal Research. 2018, 31: 276-281.
Balamurugan S, Wang X, Wang HL, An CJ, Li H, Li DW, Yang WD, Liu JS, Li HY. Occurrence of plastidial triacylglycerol synthesis and the potential regulatory role of AGPAT in the model diatom Phaeodactylum tricornutum. Biotechnol Biofuels. 2017;10:97.
Xue J, Balamurugan S, Li DW, Liu YH, Zeng H, Wang L, Yang WD, Liu JS, Li HY. Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply. Metab Eng. 2017. 41, 212–221.
Zheng JW, Li DW, Lu Y, Chen J, Liang JJ, Zhang L, Yang WD, Liu JS, Lu SH, Li HY. Molecular exploration of algal interaction between the diatom Phaeodactylum tricornutum and the dinoflagellate Alexandrium tamarense. Algal Research. 2016. 17: 132–141.
Niu YF, Wang X, Hu DX, Balamurugan S, Li DW, Yang WD, Liu JS, Li HY. Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum. Biotechnology for Biofuels. 2016. 9:60.
Xue J, Niu YF, Huang T, Yang WD, Liu JS, Li HY. Genetic improvement of a microalga Phaeodactylum tricornutum for boosting neutral lipid accumulation. Metabolic Engineering. 2015. 27(1):1-9.
WangX,LiuYH,HuDX,BalamuruganS,LuY,YangWD,LiuJS,LiHY.Identification of a putative patatin-like phospholipase domain-containing protein3(PNPLA3) ortholog involved in lipid metabolism in microalga Phaeodactylum tricornutum, Algal Research,2015(12):274-279.
YangZK,ZhengJW,NiuYF,yangWD,LiuJS,LiHY.Systems-level analysis of metabolic responses of metabolic responses of the diatom Phaeodactylum tricornutum to phosphorus stress. Environmental Microbiology. 2014.16(6):1793-1807
Xie WH, ZhuCC,ZhangNS,LiDW,YangWD,LiuJS,LiHY. Construction of novel chloroplast expression vector and development of high efficient and economical transformation system for diatom Phaeodactylum tricornutum. Marine Biotechnology.2014.16:538-546
YangZK,NiuYF,MaYH,JiaoXue,ZhangMH,YangWD,LiuJS,LuSH,GuanY,LiHY.Molecular and cellular mechanisms of neutral lipid accumulation in diatom following nitrogen deprivation. Biotechnology for Biofuels. 2013.6:67
