李姍，華中農業大學生命科學技術學院、生物醫學與健康學院 ，教授、博士生導師。
吳瑞傑出生命科學獎、國家優秀青年科學基金、湖北省傑出青年人才基金、湖北省衛計委青年人才、湖北省教育廳創新團隊等項目獲得者。
基本介紹
人物經歷,教育經歷,工作經歷,研究方向,主要成就,科研成就,主要論文,獲獎記錄,社會任職,
人物經歷
教育經歷
2003.09-2007.07 中國農業大學，工商管理（生物技術企業經營管理），學士
2003.09-2007.07 中國農業大學，生物科學，學士，導師：戚益軍教授
2013.07-2015.03北京生命科學研究所，博士後
工作經歷
01/2014-02/2017 湖北省十堰市太和醫院，感染與免疫性疾病研究所所長，中心實驗室主任，副教授，碩導
03/2017- 華中農業大學，生命科學與技術學院，生物醫學中心，教授，博導
研究方向
病原微生物與宿主互作，感染與免疫分子機制，死亡受體信號通路調節，新型蛋白質翻譯後修飾
主要成就
科研成就
李姍博士曾發現病原細菌以一種全新的蛋白質翻譯後修飾——精氨酸N-乙醯葡萄糖胺化修飾作用於死亡受體，從而抑制宿主先天性免疫反應（Li et al.,Nature, 2013），製備能特異性識別精氨酸N-乙醯葡萄糖胺化修飾的兔源單克隆抗體，為此全新修飾的研究打開了一扇大門（Pan & Li et al.,Angew. Chem. Int. Ed., 2014），受邀在細胞凋亡領域權威雜誌Apoptosis雜誌撰寫綜述（Luo et al., Apoptosis, 2015）。現主持國家自然科學基金面上項目，湖北省傑出青年人才基金項目，湖北省衛計委青年人才項目，湖北省教育廳創新團隊項目各一項。
主要論文
1. Luo J, Hu J, Zhang Y, Hu Q andLi S. (2015) Hijacking of death receptor signaling by bacterial pathogen effectors.Apoptosis20:216-223.(Corresponding author)
2. Pan M*,Li S*,Li X, Shao F, Liu L, and Hu H. (2014) Synthesis and Specific Antibody generation of Glycopeptides with ArginineN-GlcNAcylation.Angewandte Chemie International Edition53（52）：14517-14521.(Co-first author)
3.Li S*, Zhang L*, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S†, Shao F†. (2013) Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains.Nature.501, 242-246.（First author）This work was featured inNature Reviews Microbiology
4. Lu Q,Li S, and Shao F. (2015) Sweet talk: protein glycosylation in bacterial interaction with the host.Trends in microbiology23(10):630-641.
5. Lu Q, Yao Q, Xu Y, Li L,Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F (2014) An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis.Cell host & microbe16 (3):351-363.
6. Li C, Tu S, Wen S,Li S, Chang J, Shao F, Lei X.(2011) Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C.The Journal of Organic Chemistry, 76, 3566-70.
7. Cui J, Yao Q,Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. (2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.Science, 329, 1215-8.
8. Gong YN, Wang X, Wang J, Yang Z,Li S, Yang J, Liu L, Lei X, Shao F. (2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation.Cell Research, 20, 1289-305.
9. Ge J, Xu H, Li T, Zhou Y, Zhang Z,Li S, Liu L, Shao F.(2009)ALegionellatype IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors.Proc. Natl. Acad. Sci., 106, 13725-30.
10. Wei B, Cai T, Zhang R, Li A, Huo N,Li S, Gu YQ, Vogel J, Jia J, Qi Y, Mao L.(2009) Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv.Funct Integr Genomics., 9, 499-511.
11. Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L,Li S, Zhou H, Long C, Chen S, Hannon G, Qi Y. (2008) Sorting of small RNAs intoArabidopsisArgonaute complexes is directed by the 5’ terminal nucleotide.Cell, 133: 116-127. This work was featured inCell133:25-26, 2008.
12. Zhao T, Li G, Mi S,Li S, Hannon G, Wang XJ*, Qi Y.* (2007). A complex system of small RNAs in the unicellular green algaChlamydomonas reinhardtii.Genes and Development,29, 1190-1203. This work was featured in:Cell129:1029, 2007;Genes and Development21: 1153-1156, 2007;Nature447: 5, 2007;Nature447: 518, 2007;Nature Review Genetics8: 406, 2007;ACS Chemical Biology2: 436-437, 2007.
Presentations
1. 2016, Nanhu International young scientist Forum, Wuhan, China (Talk)
2. 2016, Young investigator forum of Chinese society of immunology, Haikou, China (Talk)
3. 2015, CSH-Asia Conference on Bacterial Infection and Host Defense, Suzhou, China (Poster)
4. 2014, Three places on both sides Forum, Beijing, China (Talk)
5. 2013, CSH-Asia Conference on Bacterial Infection and Host Defense, Suzhou, China (Poster Award)
6. 2013, Ray Wu Symposium, Shanghai, China (Talk)
7. 2009, Drug innovation Forum, Tianjin, China (Talk)
Honors and Awards
1.Scientific elite Prize, 2015, Taihe hospital, Hubei university of medicine;
2.Ray Wu Prize, 2013, The Ray Wu Memorial Fund(Top scholarship for biomedical Ph.D. students in china);
3.Excellent Ph.D. Student Award, 2013,NIBS, Beijing, China;
4.First Prize poster (NIBS annual retreat), 2013,NIBS, Beijing, China;
5.Research Achievement Scholarship, 2012,China Agricultural University,Beijing, China;
6.Merit student Award, 2009-2010,China Agricultural University,Beijing, China;
7.Research Achievement Scholarship, 2010,China Agricultural University,Beijing, China;
8.Research Achievement Scholarship, 2009,China Agricultural University,Beijing, China;
9.Excellent poster (NIBS annual retreat), 2009,NIBS, Beijing, China;
10.Excellent Undergraduate Thesis Award, 2007,China Agricultural University,Beijing, China;
11.Excellent Student Cadre, 2005,China Agricultural University,Beijing, China;
12.Undergraduate scholarship,2003-2006,China Agricultural University,Beijing, China;
獲獎記錄
2020年 湖北省首屆百名優秀女性科技創新人才
2016年 湖北省自然科學優秀學術論文三等獎
2013年 吳瑞傑出生命科學獎
2015年 湖北省衛健委優秀青年人才項目獲得者
2015年 湖北省傑青項目獲得者
社會任職
2020年-，Frontiers in Cell and Developmental biology專刊Associate Editor；
2017年-，Nature Communications，Cellular Microbiology等期刊審稿人；
2016年-，中國免疫學會，青年工作委員會委員；
2019年-，中國微生物學會會員；
2020年-，中國細胞生物學會，死亡研究分會委員。
