李國雲，女，1987年生，博士，中國海洋大學醫藥學院副教授。2009年6月畢業於中國海洋大學食品科學與工程專業，獲學士學位；2015年6月於中國海洋大學獲得水產品加工及貯藏工程專業博士學位。2012年9月至2014年9月在美國倫斯勒理工學院Robert J. Linhardt教授實驗室開展糖化學方面研究。2015年7月以中國海洋大學“青年英才工程”身份加入醫藥學院糖化學與糖藥物研究團隊（於廣利教授課題組）。近五年來在Anal. Chem., ACS Chem. Biol., J. Biol. Chem.等國際學術期刊發表SCI論文33篇，授權國家發明專利4項。
基本介紹
- 中文名：李國雲
- 國籍：中國
- 民族：漢族
- 出生日期：1987年
- 職業：副教授
- 畢業院校：中國海洋大學
研究方向及內容,主要代表性論文,
研究方向及內容
1．重大疾病相關的內源性糖鏈精細結構分析及其高靈敏分析方法學研究；
2. 海洋糖類化合物的提取分離、結構鑑定及其構效關係研究；
3. 糖類藥物分析、質量控制新方法研究。
主要代表性論文
1. G. Li, C. Cai, L. Li, L. Fu, T. Toida, C. Xue, R.J. Linhardt. Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry, Anal Chem, 2014,86(1): 326-330 (IF: 5.825)
2. G. Li,J. Steppich,Z. Wang,Y. Sun,C. Xue,R.J. Linhardt,L. Li. Bottom-up low molecular weight heparin analysis using LC-FTMS for extensive characterization. Anal Chem.2014,86(13):6626-6632 （IF: 5.825)
3. G. Li, L. Li, F. Tian, L. Zhang, C. Xue, R. J. Linhardt. Glycosaminoglycanomics of cultured cells using a rapid and sensitive LC-MS/MS approach. ACS Chem Biol, 2015, 10(5):1303-1310 (IF: 5.356)
4. G. Li, L. Li, C. Xue, D. Middleton, R. J. Linhardt, F. V. Avci. Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry. J Chromatogr A, 2015,1397:43-51 (IF: 4.258)
5. G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt. Analysis of 3-O-sulfo group containing tetrasaccharides in heparin by liquid chromatography-mass spectrometry. Anal Biochem, 2014, 455: 3-9. (IF: 2.305)
6. G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, R. J. Linhardt. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation.Biopolymers, 2013, 99(10):675-685 (IF: 2.228)
7. G. Li, S. Chen, C. Xue. A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity. Int J Biol Macromol, 2011, 49(5): 1160-1166 (IF: 3.096)
8. P. Datta, G. Li, B. Yang, X. Zhao, J. Baik, R.J. Linhardt. Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site. J Biol Chem, 2013, 288(52): 37308-37318. (IF: 4.600)
9. E.P. Schmidt,G. Li, L. Li, L. Fu, Y. Yang, K.H. Overdier, I. S. Douglas, R. J. Linhardt: The circulating glycosaminoglycan signature of respiratory failure in critically Ill adults. J Biol Chem, 2014, 289(12):8194-202 (IF: 4.600)
10. W. He, L. Fu, G. Li, J. A. Jones, R. J. Linhardt, M. Koffas. Production of chondroitin in metabolically engineered E. coli., Metab Eng, 2015, 27: 92-100 (IF: 8.258)
11. E. Sterner, S. Masuko, G. Li, L. Li, D. E. Green, N. J. Otto, Y. Xu, P. L. DeAngelis, J. Liu, J. S. Dordick, R. J. Linhardt. Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing, J Biol Chem 2014, 289(14): 9754-9765. (IF: 4.600)
12. S. Chen, G. Li, N. Liao, C. Xue. Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates, BBA-Gen Subjects, 2013, 1830 (4):3054-3066 (IF: 3.892)
13. L. Fu, G. Li, B. Yang, A. Onishi, L. Li, P. Sun, , R. J. Linhardt. Structural characterization of pharmaceutical heparins prepared from different animal tissues.J Pharm Sci-US, 2013,102: 1447-1457 (IF: 3.007)
14. U. Bhaskar, G. Li, L. Fu, A. Onishi, M. Suflita, R. J. Linhardt. Combinatorial one-pot chemoenzymatic synthesis of heparin, Carbohyd Polym, 2015, 122:399-407. (IF: 3.916)
