朱平，研究員，博士生導師，現任中國醫學科學院藥物研究所生物合成室主任，藥物化學系副主任。
基本介紹
人物經歷,研究方向,主要成就,所獲榮譽,代表性論文,參編專著,部分授權專利,獎勵,社會任職,
人物經歷
1988年中國協和醫科大學微生物藥物學（微生物遺傳學）專業研究生畢業，同年被分配到中國醫學科學院藥物研究所生物合成室工作，曾與1991年-1993年由原國家科委公派、歐共體資助(Postdoctoral Fllowship)在英國諾丁漢大學生命科學系John F. Peberdy實驗室從事真菌生化與遺傳學方面合作研究；2004年4月-11月，作為訪問教授在美國夏維夷大學從事海綿相關微生物的生物多樣性研究。
研究方向
微生物工程與天然藥物合成生物學。
研究內容包括：
1. 麥角菌等傳統藥用真菌的菌種選育、發酵生產和次級代謝產物生物合成研究；
2. 海綿相關真菌次級代謝產物生物合成研究；
3. 植物藥用活性成分生物合成研究。
主要成就
先後主持或參與多項國家自然科學基金、國家“863”項目、 “十一五”~“十三五”科技重大專項重大新藥創製、國家重點研發計畫“合成生物學”重點專項以及醫科院醫學與健康科技創新工程等項目。
在國內外學術期刊上累計發表學術論文100多篇，包括在Angew. Chem. Int. Ed.( 2024)(IF=16.6)、Nature Plants (2022)(IF=17.4)、Nature Communications (2017)(IF=12.4)、Acta Pharmaceutica Sinica B (2021,2022)(IF=14.9)、Green Chemistry (2023)(封2圖片介紹)(IF=11.0)、Green Chemistry (2019)(封底圖片介紹) (IF=9.4)、Chinese Chemical Letters (2024)(IF=9.1)、Molecular & Cellular Proteomics (2013) (封面圖片介紹)(IF =7.3)、Critical Reviews in Biotechnology (2019)(IF =7.1)、Fungal Diversity (2010)(IF= 5.1) 等國際知名期刊發表的SCI論文。
累計授權17項中國專利和10項國際專利，包括美國、日本、歐洲和韓國專利各2項；以色列和加拿大專利各1項。參編著作6部。獲得2011年度中國藥學會科學技術三等獎1項 (排名第2)、2022年度中國發明協會發明創業獎一等獎1項 (排名第3)、2020年度“北京協和醫學院優秀教師”稱號。合作發現3ʹ-脫氧腺苷(蟲草素)的降血脂功能及其作為AMPK激動劑的作用機制，本所相關科技人員以此為先導物，已研製出新型降血脂藥物並完成臨床前研究和技術轉讓；麥角生物鹼的研究為相關企業提供了技術支撐(菌種和技術)。
所獲榮譽
代表性論文
1) Ye D‡, Shao YZ‡, Li WR‡, Cui ZJ, Gong T, Yang JL, Wang HQ, Dai JG, Feng KP, Ma M, Ma SG*, Liu YB*, Zhu P*, and Yu SS*. Characterization and engineering of two highly paralogous sesquiterpene synthases reveal a regioselective reprotonation switch. Angew. Chem. Int. Ed. 2024, 63 (13), e202315674.
2) Peng Y, Wang Y, Chen TJ, Chen JJ, Yang JL, Gong T*, and Zhu P*. A fungal CYP from Beauveria bassiana with promiscuous steroid hydroxylation capabilities. Chinese Chem. Lett. 2024, 35(5), 108818.
3) Zhou C‡, Chen T‡, Gu A‡,Hu Z, Li Y, Gong T, Chen J, Yang J* and Zhu P*. Combining protein and metabolic engineering to achieve green biosynthesis of 12β-O-Glc-PPD in Saccharomyces cerevisiae. Green Chem., 2023, 25(4): 1356-1367(Inside front cover image from this issue).
4) Peng Y‡, Huan Y‡, Chen JJ, Chen TJ, Lei L, Yang JL, Shen ZF, Gong T* and Zhu P*. Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity. Front. Microbiol. 2023,14:1148513.
5) Huang X‡, Wang W‡, Gong T‡, Wickell D‡, ... Wei H*, Zhu P*, Li FW*, Ming R* and Li, Q*. The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence. Nat. Plants, 2022, 8(5), 500-512.
6) Jiang F, Zhou C, Li Y, Deng H, Gong T, Chen J, Chen T, Yang J*, and Zhu P*. Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3β,20S-Di-O-Glc-DM. Acta Pharm. Sin. B. 2022, 12(7):3167-3176.
7) Zhou GL, Li Y, Pei F, Gong T, Chen TJ, Chen JJ, Yang JL, Li QH*, Yu SS*, and Zhu P*. Chromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis. BMC Plant Biol., 2022, 22, 342.
8) Qiao YM, Wen YH, Gong T, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Improving ergometrine production by easO and easP knockout in Claviceps paspali. Fermentation, 2022, 8, 263.
9) Wen YH, Chen TJ, Jiang LY, Li L, Guo M, Peng Y, Chen JJ, Pei F, Yang JL, Wang RS, Gong T*, and Zhu P*. Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal α- trans-bergamotene biosynthesis. iScience, 2022, 25(4):104030.
10) Wang H‡, Zhang BY‡, Gong T, Chen TJ, Chen JJ, Yang JL, and Zhu P*. Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III. Acta Pharm. Sin. B, 2021, 11(10):3322-3334.
11) Yang L‡, Chen TJ‡, Wang F, Li L, Yu WB, Si YK, Chen JJ, Liu WC, Zhu P*, and Gong W*. Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Commun Biol. 2020, 3(1), 22.
12) Zhou GL, Zhu P*. De novo transcriptome sequencing of Rhododendron molle and identification of genes involved in the biosynthesis of secondary metabolites. BMC Plant Biol. 2020, 20(1), 414.
13) Hu ZF‡, Gu AD‡, Liang L, Li Y, Gong T, Chen JJ, Chen TJ, Yang JL*,and Zhu P*. Construction and optimization of microbial cell factories for the sustainable production of bioactive dammarenediol-II glucosides. Green Chem. 2019, 219(12), 3286-3299 (Back cover image of this issue).
14) Chen JJ, Liang X, Wang F, Wen YH, Chen TJ, Liu WC, Gong T, Yang JL,and Zhu P*. Combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. Acta Pharm. Sin. B 2019, 9(3), 626-638.
15) Liu WC, Inwood S, Gong, Sharma A, Yu LY*,and Zhu P*. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production. Crit. Rev. Biotechnol. 2019, 39(2), 258-271.
16) Zhen X‡, Gong T‡, Wen YH, Yan DJ, Chen JJ, and Zhu P*. Chrysoxanthones A–C, three new xanthone–chromanone heterdimers from sponge-associated Penicillium chrysogenum HLS111 treated with histone deacetylase inhibitor. Mar. Drugs 2018, 16, 357.
17) Gong T, Zhen X, Li XL, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Tetrocarcin Q, a New spirotetronate with a unique glycosyl group from a marine-derived actinomycete Micromonospora carbonacea LS276. Mar. Drugs2018, 16, 74.
18) Li BJ, Wang H, Gong T, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production. Nat. Commun. 2017, 8, 15544.
19) Liu WC, Gong T, Wang QH, Liang X, Chen JJ,and Zhu P*. Scaling-up fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. Sci. Rep. 2016, 6,18439.
20) Zhen X‡, Gong T‡, Liu F, Zhang PC, Zhou WQ, Li Y, and Zhu P*. A new analogue of echinomycin and a new cyclic dipeptide from a marine-derived Streptomyces sp. LS298. Mar. Drugs, 2015, 13(11), 6947-6961.
21) Liu WC, Zhu P*. Pilot studies on scale‑up biocatalysis of 7‑β‑xylosyl‑10‑deacetyltaxol and its analogues by an engineered yeast. J. Ind. Microbiol. Biotechnol. 2015, 42, 867-876.
22) Wu C, Guo Y, Su Y, Zhang X, Luan H, Zhang X, Zhu H, He H, Wang X, Sun G, Sun X, Guo P*, and Zhu P*. Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit. J. Cell. Mol. Med. 2014, 18(2), 293-304.
23) Chen HL, Zhao RY, Chen TJ, Yu WB, Wang F, Cheng KD, and Zhu P*. Cloning and characterization of the glycoside hydrolases that remove xylosyl group from 7-β-xylosyl-10-deacetyltaxol and its analogues. Mol. Cell. Proteomics. 2013,12(8), 2236-2248 (Cover image and the highlight of this issue).
24) Yu WB, Liang X, and Zhu P*. High-cell-density fermentation and pilot-scale biocatalytic studies of an engineered yeast expressing the heterologous glycoside hydrolase of 7-β-xylosyltaxanes. J. Ind. Microbiol. Biotechnol. 2013, 40, 133-140.
25) Zhu H, Hua XX, Gong T, Pang J, Hou Q, and Zhu P*. Hypocreaterpenes A and B, cadinane-type sesquiterpenes from a marine-derived fungus, Hypocreales sp. Phytochem Lett. 2013, 6, 392-396.
26) Li CQ, Liu WC, and Zhu P*, Yang JL, and Cheng KD. Phylogenetic diversity of bacteria associated with the marine sponge Gelliodes carnosa collected from the Hainan island coastal waters of the South China Sea. Microb. Ecol. 2011,62, 800-812.
27) Liu WC, Li, CQ, Zhu P*. Yang JL, and Cheng KD. Phylogenetic diversity of culturable fungi associated with two marine sponges: Haliclona simulans and Gelliodes carnosa, collected from the Hainan Island coastal waters of the South China Sea. Fungal Divers. 2010, 42, 1-15.
參編專著
1. Liu WC, Li BJ, Gong T, and Zhu P (2020). Exploring alternative Taxol sources: Biocatalysis of 7-β-xylosyl-10-deacetyltaxol and application for Taxol production. In: Pharmaceutical Biocatalysis. Peter Grunwald eds. Jenny Stanford Publishing.
2. Liu WC and Zhu P (2018). Demonstration-scale high-cell-density fermentation of Pichia pastoris. In: Recombinant Glycoprotein Production: Methods and Protocols. Methods in Molecular Biology, Vol 1674, Picanço-Castro V and Swiech K eds. Humana Press, New York, NY.
3. Zhu P and Wn H (2011). Medicinal fungal research in China. In: McGraw-Hill Year Book of Science & Technology 2011. Blumel D et al. eds. The McGraw-Hill Companies, Inc.
4. Cheng K, Liu T, Meng C, and Zhu P (2007). Biotechnological studies on Anisodus tanguticus. In: Recent Progress in Medicinal Plants. Volume 16, Book chapter: Phytomedicines. Govil JN et al. eds. Studium Press LLC, U.S.A.
5. 《中國食用藥用菌化學》 陳若芸 主編. 第五章 蕈菌毒素(鞏婷, 朱平), 第十六章 麥角菌(陳晶晶,王維波,鞏婷, 朱平). 上海科學技術文獻出版社, 2016.
6. 《天然藥物化學研究》方起程 主編. 第七章 第三節 麥角生物鹼生物合成的研究(朱平,胡晨曦), 第四節 後基因組時代與天然藥物化學——紫杉烷類化合物生物合成(程克棣, 王偉, 朱平 ).中國協和醫科大學出版社, 2006.
部分授權專利
1. 朱平，朱海波，朱慧新，張嶺，何惠霞，王全，程克棣，石建功，楊永春. 3ʹ-脫氧腺苷在製備降血脂藥物中的套用. ZL 200310101650.7.
2. 朱海波，吳松，郝玲花，渠凱，朱平，王星，李薇. 三乙醯基-3-羥基苯基腺苷及其調血脂的用途. PCT/CN2009/070725, ZL 200980101131.6, US 8,435,962, EU 2407474, JP 5698682, KR10-1380140, IL 215080.
3. 朱平，程海立，趙瑞玉，程克棣，何惠霞，孟超，朱慧新. 一種7-木糖紫杉烷糖基水解酶、其基因的核苷酸序列及其套用. ZL 201010209089.4
4. 朱平，程海立，趙瑞玉，程克棣，何惠霞，孟超，朱慧新. 具有b-木糖苷酶和b-葡萄糖苷酶活性的糖基水解酶及其套用. PCT/WO2011/160484A1, ZL 201180031238.5, US 9,206,405 B2, EP2586860B1, CA2804879, JP 5868395 B2, KR10-1830131.
5. 朱平，梁瀟，王芬，李慧仙，陳天嬌. 具有β-木糖苷酶和β-葡萄糖苷酶雙重活性的糖基水解酶突變體及其套用. ZL 2016 1 0141218.8.
6. 朱平，李炳娟，王豪，陳天嬌，陳晶晶，鞏婷，楊金玲.10-去乙醯巴卡亭III 10β-O-乙醯轉移酶突變體及其在催化合成紫杉醇及其類似物中的套用. ZL 201610346558.4.
7. 朱平，李炳娟，王豪，陳天嬌，陳晶晶，鞏婷，楊金玲. 利用10-去乙醯巴卡亭III 10β-O-乙醯轉移酶突變體催化合成紫杉醇及其類似物. ZL 202110477408.8.
8. 楊金玲，朱平，李燕，陳天嬌，顧安頔，杜倩倩. 3β-O-Glc-DM和20S-O-Glc-DM治療肺癌或結直腸癌的用途. ZL 201980075637.8
9. 楊金玲，朱平，李燕，姜逢霖，杜倩倩，唐梅. 非天然人參皂苷 3β-O-Glc-DM 在製備預防或治療膠質母細胞瘤藥物中的套用. ZL 201910403991.0.
10. 李燕，楊金玲，朱平，唐梅，顧安頔. 稀有人參皂苷在治療腎癌中的用途. ZL 202011129395.7.
獎勵
1. 稀有天然藥物生物合成與合成生物學研究.中國藥學會科學技術獎 三等獎（2011）。
2. 基於蟲草素結構最佳化的新型運動模擬候選藥物研發關鍵技術及其套用. 中國發明協會發明創業獎 一等獎 (2022)。
3. 北京協和醫學院優秀教師 (2020)。
社會任職
中國菌物學會副理事長，《藥學學報》、《菌物學報》、《中國醫藥生物技術》、《藥學研究》、《菌物研究》雜誌編委。
曾任國家衛健委天然藥物生物合成重點實驗室主任、中國中藥協會藥用菌物專業委員會主任委員等。
