基本介紹
- 中文名：昌鳴先
- 畢業院校：華中農業大學
- 職業：教師
- 性別：女
- 職稱：研究員
- 學歷：研究生
人物經歷,研究方向,科研成果,代表論著,科研活動,
人物經歷
2001年畢業於華中農業大學獲碩士學位；2005年畢業於中國科學院水生生物研究所獲博士學位並留所工作；2007年晉升為副研究員。2008年6月至11月在英國阿伯丁大學進行合作研究。2009年3月到2010年3月在英國阿伯丁大學作訪問學者。2015年1月起任中國科學院水生生物研究所研究員。
已在Molecular immunology、Fish and Shellfish Immunology、Parasitology Research、Veterinary Immunology and Immunopathology、Immunogenetics等刊物上發表論文20餘篇。
研究方向
抗病原體感染的分子機制，免疫系統基因的可變剪接及其功能，病原體-宿主的相互作用
科研成果
代表論著
1. Chang MX, Zou J, Nie P, Huang B, Yu Z, Collet B, Secombes CJ*. Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013, 9(11):e1003736.
2. Chang M, Collet B, Nie P*, Lester K, Campbell S, Secombes CJ, Zou J*. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in rainbow trout (Oncorhynchus mykiss). J Virol. 2011,85(16):8403-12.
3. Chang MX, Wang T, Nie P, Zou J, Secombes CJ*. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol. 2011,30(1):118-27.
4. Chang MX, Chen WQ, Nie P*. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Dev Comp Immunol. 2010;34:1-13.
5. Chang MX, Wang YP, Nie P*. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish Shellfish Immunol. 2009;26:264-74.
6. Chang MX, Nie P, Collet B, Secombes CJ, Zou J*. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 2009;61:315-25.
7. Chang MX, Nie P*. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301.
8. Chang MX, Nie P*, Wei LL. Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Mol Immunol. 2007;44(11):3005-23.
9. Chang MX, Sun BJ, Nie P*. The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Mol Immunol. 2007;44(6):1123-34.
10. Fan Y, Chang MX, Ma J, LaPatra SE, Hu YW, Huang L, Nie P*, Zeng L*. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus. Vet Res. 2015;46:136.
11. Zhang L, Chen WQ, Hu YW, Wu XM, Nie P, Chang MX*. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway.Fish Shellfish Immunol. 2016;54:135-43.
12. Zou PF, Chang MX*, Li Y, Zhang SH, Fu JP, Chen SN, Nie P*. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43(1):13-24.
13. Zou PF, Chang MX*, Xue NN, Liu XQ, Li JH, Fu JP, Chen SN, Nie P*. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141(2):192-202.
14. Li JH, Chang MX*, Xue NN, Nie P*. Functional characterization of a short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2013;35(2):221-30.
15. Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX*. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49(1):19-30.
16. Yu ZL, Li JH, Xue NN, Nie P, Chang MX*. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;47(2):264-74.
17. Hu YW, Yu ZL, Xue NN, Nie P, Chang MX*. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Dev Comp Immunol. 2014;46(2):323-32.
18. Li JH, Yu ZL, Xue NN, Zou PF, Hu JY, Nie P, Chang MX*. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;42(2):244-55.
19. Wang G, Li J, Zou P, Xie H, Huang B, Nie P, Chang M*. Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2012;33(3):522-31.
20. Guo HZ, Zou PF, Fu JP, Guo Z, Zhu BK, Nie P, Chang MX*. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis.Fish Shellfish Immunol. 2011,30(2):515-24.
科研活動
科研項目
（ 1 ） 魚類模式識別受體在信號傳導通路及免疫反應中的作用, 主持, 國家級, 2009-01--2012-12
（ 2 ） 淡水池塘集約化養殖的基礎科學問題研究, 參與, 國家級, 2009-01--2013-12
（ 3 ） 草魚肽聚糖識別蛋白不同剪接異構體在抗菌及炎症反應中的作用, 主持, 國家級, 2012-01--2015-12
（ 4 ） 斑馬魚胞內模式識別受體NLRC5在抗感染中的作用及其機制, 主持, 國家級, 2014-01--2017-12
（ 5 ） 斑馬魚CD44在胸腺T細胞發育以及免疫調節中的作用及其機制, 主持, 國家級, 2017-01--2020-12
（ 6 ） 魚類組蛋白H2A基因的核苷酸多態性及其在病原感染中的作 用, 主持, 國家級, 2019-01--2022-12
參與會議
（1）魚類NOD1/RIP2信號在幼魚發育以及免疫反應中的調控作用及其機制 2018年魚類分子免疫學前沿論壇 2018-10-15
（2）魚類NLR和RLR受體的相互調控對免疫反應的影響 2018水生動物免疫學研討會 2018-06-13
（3）魚類模式識別受體在信號傳導通路以及免疫反應中的作用 中國水產學會魚病專業委員會學術討論會 2013-11-05
（4）Activation of intracellular antiviral immune responses by antibacterial pattern recognition receptor NOD1 第一屆魚貝免疫學國際會議 2013-06-25
