文鐘靈

文鐘靈博士，南京大學生命科學學院準聘助理教授/特任研究員。

研究方向：

1. 植物與根際微生物互作生態機理；

2. 微生物分子生態與功能；

3. 植物分子代謝及其生物合成調控。

基本介紹

• 中文名：文鐘靈
• 國籍：中國
• 民族：漢
• 畢業院校：南京大學
• 職業：教師

於2020年在南京大學獲理學博士學位，2021-2023年在南京大學從事博士後研究工作。研究方向為植物與根際微生物互作生態機理，微生物分子生態與功能，植物分子代謝及其生物合成調控。代表性研究成果發表在Hortic Res、EnvironMicrobiome、Environ Res、J HazardMater、EnvironPollut、MicrobBiotechnol、Biol Fertil Soils等本領域知名期刊上。近五年主持國家級科研項目4項，並作為主要負責人參與項目3項。任江蘇省植物生理學會理事。擔任Hortic Res、EnvironMicrobiome、Sci TotalEnviron、Plant Soil等雜誌審稿人。

主要研究介紹

主要從事植物與根際微生物的互作的生態機理研究，涉及生物、非生物環境脅迫對微生物群落結構、遺傳與功能多樣性的影響及其評價，聚焦土壤微生物群落分子多樣性度量，評估植物與根際微生物互作對植物生長、次生代謝物形成、產量等性狀的作用；藉助人工合成群落手段，提高各類脅迫環境下作物生長產量，探索以根入藥植物的次生代謝生物合成及其調控，並闡明相應分子生態機制。

至今已在土壤生態學、環境生物學、微生物學、植物藥化藥理等領域國際SCI期刊（包括HorticRes、J Hazard Mater、Environ Microbiome、EnvironRes等）發表相關研究或評述論文50篇（其中第一/通訊作者身份論文20篇），獲2022年第四季度“Wiley威立中國開放科學高貢獻作者”稱號；申請國家專利5件。近年來主持國家級項目4項，包括國家自然科學基金青年項目1項、中國博士後科學基金2項、國家外國專家個人類項目(Y類) 1項；作為主要骨幹，參與國家級項目3項。在第十一屆低pH值下植物-土壤相互作用國際會議及江蘇省遺傳學會2024年學術年會作大會報告和大會青年科學家報告。

近五年部分代表性研究成果

1. Wen Zhongling, Yang Minkai, FazalAliya, Han Hongwei,Lin Hongyan, Yin Tongming, Zhu Yuelin, Yang Shouping, Niu Kechang, Sun Shucun,Qi Jinliang, Lu Guihua*, Yang Yonghua*. Harnessing the power of microbes:Enhancing soybean growth in an acidic soil through AMF inoculation rather thanP-fertilization, Horticulture Research, 2024, 11: uhae067. (IF_5年=8.2)

2. Yang Minkai, Song Yuhang, Ma Hanke, Li Zhenghua,Ding Jiawei, Yin Tongmin, Niu Kechang, Sun Shucun, Qi Jingliang, Lu Guihua,Fazal Aliya*, Yang Yonghua*, WenZhongling*. Unveiling the hidden world: How arbuscular mycorrhizal fungiand its regulated core fungi modify the composition and metabolism of soybeanrhizosphere microbiome. EnvironmentalMicrobiome, 2024,19:78. (IF_5年=7.1)

3. Fazal Aliya,Yang Minkai, Han Hongwei, Lu Guihua, HaoChenyu, Lai Xiaohui, Song Yuhang, Ma Hanke, Yin Tongming, Qi Jingliang, Sun Shucun, Niu Kechang, WenZhongling*, Yang Yonghua*. Impactof dual Bt-transgenic maize (2A7) on soil microbial communities and enzymeactivities: A comparative study with control variety Z58. Environmental Research, 2024,263:120006. (IF_5年=7.5)

4. Li Dongbao,Yang Wen, Wu Zhiyue, Yang Yonghua, Wen Zhongling*, Sun Bo*. SlKNUCKLES regulates floral meristem activity and controls fruit sizein Solanum lycopersicum. Horticulture Research, 2025,12(3):uhae331. (IF_5年=8.2)

5. Fazal Aliya,Yang Minkai, Wang Xuan, Lu Yunting, Yao Weixuan, LuoFuhe, Han Mi, Song Yuchen, Cai Jinfeng, Yin Tongming, Niu Kechang, Sun Shucun,Qi Jinliang, Lu Guihua, Wen Zhongling*, Yang Yonghua*. Discrepancies in rhizobacterial assembly caused by glyphosate applicationand herbicide-tolerant soybean co-expressing GAT and EPSPS. Journal of Hazardous Materials,2023, 450: 131053. (IF_5年=11.9)

6. Fazal Aliya, WenZhongling, Yang Minkai, Wang Changyi,Hao Chenyu, Lai Xiaohui, Jie Wencai, Yang Liu, He Zhuoyu, Yang Huan, CaiJinfeng, Qi Jinliang, Lu Guihua, Niu Kechang, Sun Shucun, Yang Yonghua*.Triple-transgenic soybean in conjunction with glyphosate drive patterns in therhizosphere microbial community assembly.Environmental Pollution, 2023, 335: 122337. (IF_5年=8.3)

7. Wen Zhongling, Yang Minkai,Han Hongwei, Fazal Aliya, Liao Yonghui, Ren Ran, Yin Tongming, Qi Jinliang, SunShucun, Lu Guihua*, Hu Shuijin*, Yang Yonghua*. Mycorrhizae enhance soybeanplant growth and aluminum stress tolerance by shaping the microbiome assemblyin an acidic soil. Microbiology Spectrum, 2023, 11: e03310-22.(IF_5年=4.2)

8. Yang Minkai, Luo Fuhe, Song Yuchen, Ma Shenglin, MaYudi, Fazal Aliya, Yin Tongming, Lu Guihua, Sun Shucun, Qi Jinliang, Wen Zhongling*, Li Yongchun*, Yang Yonghua*. The host niches of soybean rather thangenetic modification or glyphosate application drive the assembly ofroot-associated microbial communities.MicrobialBiotechnology, 2022, 15: 2942-2957. (IF_5年=5.8)

9. Wen Zhongling, Yao Weixuan, Han Mi, Xu Xinhong, Wu Fengci,Yang Minkai, Fazal Aliya, Yin Tongming, Qi Jinliang, Lu Guihua, Yang Rongwu*, Song Xinyuan*, Yang Yonghua*. Differential assembly ofroot-associated bacterial and fungal communities of a dual transgenicinsect-resistant maize line at different host niches and different growthstages. Frontiers inMicrobiology, 2022, 13: 1023971. (IF_5年=5.1)

10. Han Hongwei, WenZhongling, Yang Minkai, Wang Changyi,Ma Yudi, Chen Qingqing, Jiang Dexing, Xu Ye, Fazal Aliya, Jie Wencai, LvXiaoran, Yin Tongming, Lin Hongyan, Lu Guihua, Qi Jinliang, Yang Yonghua*, XuGuohua*. Shikonin derivative suppresses colorectal cancercells growth via reactive oxygen species-mediated mitochondrial apoptosis andpi3k/akt pathway. Chemistry & Biodiversity. 2025, 22, e202403291. (IF_5年=2.5)

11. Han Hongwei,Yang Minkai, Wen Zhongling, Mei Feng, ChenQingqing, Ma Yudi, Lai Xiaohui, Zhang Yahan, Fang Rongjun, Yin Tongming, SunShucun, Wang Xiaoming, Qi Jinliang, Lin Hongyan*, Yang Yonghua*.Trametinib and m17, a novel small molecule inhibitor of akt, display asynergistic antitumor effect in triple negative breast cancer cells through theakt/mtor and mek/erk pathways. BioorganicChemistry 2024, 154, 107981.(IF_5年=4.7)

12. Han Hongwei,Yang Minkai, Wen Zhongling, Wang Xuan, LaiXiaohui, Zhang Yahan, Fang Rongjun, Yin Tongming, Yang Xiaorong, Wang Xiaoming,Zhao Quan, Qi Jinliang, Chen Hongyuan, Lin Hongyan*, Yang Yonghua*. A modified natural small molecule inhibits triple-negative breast cancergrowth by interacting with Tubb3. Phytomedicine, 2024, 126: 154894. (IF_5年=6.2)

13. Ma Yudi, LaiXiaohui, Wen Zhongling, Zhou Ziling,Yang Minkai, Chen Qingqing, Wang Xuan, Mei Feng, Yang Liu, Yin Tongming, SunShucun, Lu Guihua, Qi Jinliang, Lin Hongyan*, Han Hongwei*, Yang Yonghua*.Design, synthesis and biological evaluation of novel modified dual-targetshikonin derivatives for colorectal cancer treatment. Bioorganic Chemistry, 2023,139: 106703. (IF_5年=4.7)

14. 文鐘靈、楊旻愷、陳星雨、郝晨宇、任然、儲淑娟、韓洪葦、林紅燕、陸桂華、戚金亮、楊永華*.酸鋁脅迫土壤中耐鋁大豆根際不同部位細菌群落結構、功能及其對促生菌富集作用的研究. 遺傳, 2021, 43:487-507.

15. Li Yongchun,Li Yongfu, Yang Minkai, Chang Scott X., Qi Jinliang, Tang Caixian, WenZhongling, Hong Zhi, Yang Tongyi, Ma Zilong, Gao Qun, Zhou Jizhong, YangYunfeng*, Yang Yonghua*. Changes of microbial functional capacities in therhizosphere contribute to aluminum tolerance by genotype-specific soybeans inacid soils. Biologyand Fertility of Soils, 2020, 56: 771-783. (IF_5年=6.2)