張竹君 女 南開大學醫學院副教授·。
基本介紹
- 中文名：張竹君
- 國籍：中國
- 民族：漢
- 職業：南開大學醫學院副教授
人物經歷,研究方向,主要貢獻,
人物經歷
1999.4-2004.3 神戶大學醫學院兒科，醫學博士學位
1990.9-1995.7 中國醫科大學臨床醫學專業，醫學學士學位
2008.11至今 南開大學醫學院，副教授
2004.4-2008.10 日本神戶大學醫學院兒科，博士後
2004.4-2008.10 日本神戶大學醫學院兒科，博士後
研究方向
1．研究領域：遺傳病的分子診斷和分子治療的研究:
(1) 開發快速分子診斷方法。
(2) 研究微小突變對splicing的影響及機理。
(3) 套用人工合成反義寡聚核苷酸治療Duchenne型肌營養不良。
2．科研項目：承擔一項國家自然科學基金面上項目，項目編號：30971590
主要貢獻
1. Takeshima Y, Yagi M, Okizuka Y, Awano H, Zhang Z, Yamauchi Y, Nishio H, Matsuo M. Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center. J Hum Genet 2010; 55 (6): 379-88.
2. Zhang Z, Yagi M, Okizuka Y, Awano H, Takeshima Y, Matsuo M. Insertion of IL1RAPL1 gene into the duplication junction of the dystrophin gene. J Hum Genet 2009; 54(8): 466-73.
3. Nishiyama A, Takeshima Y, Zhang Z, Habara Y, Tran TH, Yagi M, Matsuo M. Dystrophin nonsense mutations can generate alternative rescue transcripts in lymphocytes. Ann Hum Genet 2008; 72: 717-24.
4. Zhang Z, Takeshima Y, Awano H, Nishiyama A, Okizuka Y, Yagi M, Matsuo M. Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy. J Hum Genet 2008; 53(3):215-9.
5. Sahashi K, Masuda A, Matsuura T, Shinmi J, Zhang Z, Takeshima Y, Matsuo M, Sobue G, Ohno K . In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites. Nucleic Acids Res 2007; 35(18):5995-6003.
6. Zhang Z, Yasuaki Habara, Atsushi Nishiyama, Yoshinobu Oyazato, Mariko Yagi, Yasuhiro Takeshima and Masafumi Matsuo. Identification of seven novel cryptic exons embedded in the dystrophin gene and characterization of 14 cryptic dystrophin exons. J Hum Genet 2007; 52(7):607-17.
7. Tran VK, Takeshima Y, Zhang Z, Habara Y, Haginoya K, Nishiyama N, Yagi M and Matsuo M. A nonsense mutation-created intraexonic splice site is active in the lymphocytes, but not in the skeletal muscle of a DMD patient. Human Genet 2007; 120(5): 737-42.
8. Tran VK, Takeshima Y, Zhang Z, Yagi M, Nishiyama N, Habara Y and Matsuo M. Splicing analysis disclosed a determinant single nucleotide for exon skipping caused by a novel intra-exonic four-nucleotide deletion in the dystrophin gene. J Med Genet 2006; 43(12): 924-30.
2. Zhang Z, Yagi M, Okizuka Y, Awano H, Takeshima Y, Matsuo M. Insertion of IL1RAPL1 gene into the duplication junction of the dystrophin gene. J Hum Genet 2009; 54(8): 466-73.
3. Nishiyama A, Takeshima Y, Zhang Z, Habara Y, Tran TH, Yagi M, Matsuo M. Dystrophin nonsense mutations can generate alternative rescue transcripts in lymphocytes. Ann Hum Genet 2008; 72: 717-24.
4. Zhang Z, Takeshima Y, Awano H, Nishiyama A, Okizuka Y, Yagi M, Matsuo M. Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy. J Hum Genet 2008; 53(3):215-9.
5. Sahashi K, Masuda A, Matsuura T, Shinmi J, Zhang Z, Takeshima Y, Matsuo M, Sobue G, Ohno K . In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites. Nucleic Acids Res 2007; 35(18):5995-6003.
6. Zhang Z, Yasuaki Habara, Atsushi Nishiyama, Yoshinobu Oyazato, Mariko Yagi, Yasuhiro Takeshima and Masafumi Matsuo. Identification of seven novel cryptic exons embedded in the dystrophin gene and characterization of 14 cryptic dystrophin exons. J Hum Genet 2007; 52(7):607-17.
7. Tran VK, Takeshima Y, Zhang Z, Habara Y, Haginoya K, Nishiyama N, Yagi M and Matsuo M. A nonsense mutation-created intraexonic splice site is active in the lymphocytes, but not in the skeletal muscle of a DMD patient. Human Genet 2007; 120(5): 737-42.
8. Tran VK, Takeshima Y, Zhang Z, Yagi M, Nishiyama N, Habara Y and Matsuo M. Splicing analysis disclosed a determinant single nucleotide for exon skipping caused by a novel intra-exonic four-nucleotide deletion in the dystrophin gene. J Med Genet 2006; 43(12): 924-30.
