張敬宇

張敬宇,女,博士,華東理工大學生物工程學院助理研究員。

基本介紹

  • 中文名:張敬宇
  • 職業:教師
  • 畢業院校:中國藥科大學
  • 學位/學歷:博士
  • 專業方向:微生物來源的活性天然產物挖掘
  • 任職院校:華東理工大學
個人經歷,榮譽獎項,研究方向,主講課程,學術成果,

個人經歷

2012年6月畢業於中國藥科大學藥物化學專業,獲得理學博士學位,同年進入中科院微生物研究所從事博士後研究(合作導師張立新教授)。2016年9月加入華東理工大學生物工程學院。

榮譽獎項

曾獲得中國科學院病原微生物與免疫學重點實驗室利德曼杯優秀研究生獎二等獎、多次參加國際學術會議並做報告,獲得2017年第六屆實驗室自動化與篩選國際會議的Travel award(全球6名/屆)

研究方向

  1. 微生物來源的活性天然產物挖掘基於生物信息學技術,快速發現放線菌和真菌來源的新穎活性天然產物。
  2. 新穎活性天然產物的生物合成機制解析利用異源表達等策略解析活性天然產物生物合成機制。

主講課程

  1. 研究生課程:合成生物學與天然產物藥物發現(全英文),32學時,2學分。
  2. 本科生課程:化學生物學,32學時,2學分。

學術成果

主持和參加的科研項目:
  1. 國家自然科學基金面上項目(21877038),2019/1-2022/12,63萬,主持
  2. 國家自然科學基金青年基金(81302678),2014/1-2016/12,23萬,主持
  3. 國家重點研發計畫子課題技術骨幹(2019YFA0906201),2020/1-2024/12,425萬,項目骨幹
  4. 國家“十二五”重大傳染病專項(2013ZX10005004-005),2013/1-2015/12,399.85萬,項目骨幹
  5. 國家自然科學基金面上項目(81573341),2016/1-2019/12,64萬,項目骨幹
代表性論文(*:通訊作者;#:貢獻相同):
1.Weishan Wang, Shanshan Li, Zilong Li,Jingyu Zhang, Keqiang Fan,Gaoyi Tan, Guomin Ai, Sin Man Lam, Guanghou Shui, Zhiheng Yang, Hongzhong Lu, Pinjiao Jin, Yihong Li, Xiangyin Chen, Xuekui Xia, Xueting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang, Siliang Zhang,Gil Alterovitz, Wensheng Xiang, & Lixin ZhangHarnessing the intracellular triacylglycerols for titer improvement of polyketides inStreptomyces,Nature Biotechnology,2020,
2.Jingyu Zhang, Bixiao Li, Yujie Qin, Loganathan Karthik, Guoliang Zhu, Chengjian Hou, Lan Jiang, Miaomiao Liu, Xin Ye, Mei Liu, Tom Hsiang, Huanqin Dai*, Zhang LX*, and Xueting Liu,*. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derivedVerrucosisporasp. MS100137.Applied Microbiology Biotechnology,2019,
3.Zhang, Jingyu, Wang, Zhenzhen, Song, Zhijun, Karthik, Loganathan, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Han, Jianying, Ma, Rong, Li, Li, Zhang, Lixin*, Liu, Xueting*, Hsiang, Tom*. Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus,Microdochium majus99049.Synthetic and Systems Biotechnology. 2019,
4.Jingyu Zhang, Jianying Han, Ayokunmi Oyeleye, Miaomiao Liu, Xueting Liu*, Lixin Zhang* Extraction Methods of Natural Products from Traditional Chinese Medicines,Chemical Biology: Methods and Protocols,2015,
5.Jianying Han,Jingyu Zhang, Wenni He, Pei Huang, Ayokunmi Oyeleye, Xueting Liu*, Lixin Zhang* Bioassay-Guided Identification of Bioactive Molecules from Traditional Chinese Medicines,Chemical Biology : Methods and Protocols,2015
6.Jingyu Zhang, Wael M. Abdel-Mageed, Miaomiao Liu, Pei Huang, Wenni He, Li Li, Fuhang Song, Huanqin Dai, Jingyu Liang, Xueting Liu*, Lixin Zhang* Caesanines A–D, New Cassane Diterpenes with Unprecedented N Bridge fromCaesalpinia sappan,Organic Letters,2013,
7.Jingyu Zhang, Wei Qu, Jing Yu Liang*.A NOVEL INDOLOMONOTERPENIC ALKALOID FROM PROCESSEDSemen Strychni.Chemistry of Natural Compounds, 2012,
8.Jingyu Zhang, Fei Hua Wu, Wei Qu, Jing Yu Liang*. Two new cassane diterpenoids from the seeds ofCaesalpinia sappanLinn.Chinese Journal of Natural Medicines, 2012,
9.Jingyu Zhang, Wei Qu, Jing Yu Liang*. A new cassane furanoditerpenoid from the seeds ofCaesalpinia sappan.Journal of China Pharmaceutical University,2012,
10.Mindong Liang, Zilong Li, Weishan Wang, Jiakun Liu, Leshi Liu, Guoliang Zhu, Loganathan Karthik, Man Wang, Ke-Feng Wang, Zhong Wang, Jing Yu, Yuting Shuai, Jiaming Yu, Lu Zhang, Zhiheng Yang, Chuan Li, Qian Zhang, Tong Shi, Liming Zhou, Feng Xie, Huanqin Dai, Xueting Liu,Jingyu Zhang, Guang Liu, Ying Zhuo, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gil Alterovitz, Gao-Yi Tan * & Li-Xin Zhang *. 2019. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules.Nature Communication. 2019
11.Han J,Zhang Jingyu, Song Z, Liu M, Hu J, Hou C, Zhu G, Jiang L, Xia X, Quinn RJ, Feng Y, Zhang LX*,Hsiang T*, Liu X*. 2019. Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134.Appl Microbiol Biotechnol.
12.Wael M. Abdel-Mageed,Soad A. L. Bayoumi,Lamya H. Al-wahaibi, Li Li,Mohamed S. A. Abdelkader,Hanaa M. Sayed,Mei Liu,Jingyu Zhang,Xueting Liu,*Lixin Zhang*. Non-Cyanogenic Cyanoglucoside Cyclooxygenase Inhibitors fromSimmondsia chinensis.Organic Letters, 2016,
13.Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Fuhang Song, Huanqin Dai,Jingyu Zhang, Krishna Bolla, Ronald Quinn, Tanja Grkovic, Houwei Luo, Lixin Zhang*,Xueting Liu*.Discovery of tashinone derivatives with anti-MRSA activity via targeted bio-transformation.Synthetic and Systems Biotechnology, 2016,
14.Wenni He, Miaomiao Liu, Xiaolin Li,Xiaoping Zhang, Wael M. Abdel-Mageed, Li Li, Wenzhao Wang,Jingyu Zhang, Jianying Han, Huanqin Dai,Ronald J. Quinn, Hung-wen Liu, Houwei Luo, Xueting Liu, * and Lixin Zhang* Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: Evidence for enzyme catalysis and increased antibacterial activity.Applied Microbiology and Biotechnology, 2016,
15.Ling Zhao, Jing Yu Liang*,Jingyu Zhang, Yun Chen. A novel diarylheptanoid bearing flavonol moiety from the rhizomes of Alpinia offcinarum Hance.Chinese Chemical Letters2010,
專利:
  1. 張立新、梁敬鈺、張敬宇、劉雪婷、劉苗苗,一種抗菌化合物及其製備方法與套用,專利號:201310378741.9,授權公告日:2015年5月27日
  2. 葉昕、張立新、秦玉潔、劉雪婷、葉榛、張敬宇、童曉梅,,化合物AJ-4在製備治療或預防流感病毒的藥物中的套用,授權公告日:2019年1月15日
  3. 葉昕、張立新、秦玉潔、劉雪婷、葉榛、張敬宇、童曉梅,化合物AJ-2在製備治療或預防流感病毒的藥物中的套用,授權公告日:2019年2月12日
  4. 張立新,劉雪婷,張敬宇,蔣嵐,朱國良,韓建營,侯成劍,李碧霄,一類來源於植物病原真菌的helminthosporol型倍半萜類化合物及其製備方法與套用。
  5. 張立新,劉雪婷,張敬宇,朱國良,蔣嵐,韓建營,侯成劍,李碧霄,一類來源於植物病原真菌的5-15環二倍半萜化合物及其製備方法與套用。
  6. 張立新,王婷,張敬宇,張麗,劉雪婷,李耀,王珍珍,吳珂,一個來源於海洋鏈黴菌的碳磷化合物的分離製備方法,
  7. 張立新,吳珂,劉雪婷,張敬宇,朱國良,譚高翼,王珍珍,來源於鏈黴菌的碳磷化合物及其製備方法與套用,
  8. 高強,張立新,胡棟,張敬宇,譚高翼,一種阿維鏈黴菌合成培養基及其發酵液的製備方法;公開
  9. 張立新,王為善,李珊珊,李子龍,譚高翼,范可強,張敬宇,提高鏈黴菌聚酮化合物產量的方法

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