張天藍

張天藍，北京大學藥學院教授，博士生導師。

基本介紹

• 中文名：張天藍
• 職業：北京大學藥學院教授，博士生導師
• 畢業院校：華南工學院
• 研究方向：抗白血病藥物和生物礦化

人物經歷

1978年10月至1982年7月就讀於華南工學院化學系，獲化學專業理學學士學位。1984年9月至1987年7月就讀於鄭州大學/河南化學研究所，獲無機化學專業理學碩士學位，此後在河南化學研究所從事配合物光化學和激發態電化學研究。1994年9月至1995年9月在英國帝國理工學院光分子科學中心(Centre for Photomolecular Sciences, Imperial College, London)學習光生物化學。1995年任河南化學研究所副研究員。1996年9月至1999年7月就讀於北京醫科大學，獲藥物化學專業理學博士學位並留校任教。2000年轉為副教授，2004年至今為教授；其間，2005年6月至2008年1月曾任首都醫科大學教授。

研究方向

主要研究方向是抗白血病藥物和生物礦化。

主要貢獻

1.Bian, S.; Du, L.-W.; Gao, Y.-X.; Huang, J.; Gou, B.-D.; Li, X.; Liu, Y.; Zhang, T.-L.; Wang, K., Crystallization in aggregates of calcium phosphate nanocrystals: A logistic model for kinetics of fractal structure development. Cryst. Growth Des. 2012, 12 (7), 3481-3488.

2.Zhao, W.-H.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells. J. Cell. Biochem. 2012,113(5), 1776-1786.

3.Bao-Di Gou, Sha Bian, Tian-Lan Zhang and Kui Wang. Gadolinium-promoted precipitation of calcium phosphate is associated with profibrotic activation of RAW 264.7 macrophages. Toxicology in Vitro, 2010; 24, 1743-1749.

4.Chen-Guang Wang, Jia-Wang Liao, Bao-Di Gou, Jian Huang, Rui-Kang Tang, Jin-Hui Tao, Tian-Lan Zhang, and Kui Wang. Crystallization at multiple sites inside particles of amorphous calcium phosphate. Cryst. Growth Des. 2009; 9, 2620-2626.

5.Yan-Ling Shi, Li-Wen Wang, Jian Huang, Bao-Di Gou, Tian-Lan Zhang, and Kui Wang. Lanthanum suppresses osteoblastic differentiation via pertussis toxin-sensitive G protein signaling in rat vascular smooth muscle cells. J. Cell. Biochem. 2009; 108, 1184–1191.

6.Li-Wen Wang, Yan-Ling Shi, Nan Wang, Bao-Di Gou, Tian-Lan Zhang, Kui Wang. Association of oxidative stress with realgar-induced differentiation in human leukemia HL-60 cells. Chemotherapy 2009; 55:460–467.

7.Yu Shi，Bao-Di Gou，Yan-Ling Shi，Tian-Lan Zhang，Kui Wang. Lanthanum chloride suppresses hydrogen peroxide-enhanced calcification in rat calcifying vascular cells. Biometals 2009; 22, 317-327.

8.Jian Huang, Xi Wang, Tian-Lan Zhang, Kui Wang. Alterations of ovariectomized rat bone and impact of non-collagenous proteins on mineralization. Joint Bone Spine 2009; 76, 176-183.

9.Xi Wang, Lan Yuan, Jian Huang, Tian-Lan Zhang, Kui Wang. Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive Gi protein and ERK signaling pathway. J. Cell. Biochem. 2008; 105, 1307–1315.

10.Nan Wang, Li-Wen Wang, Bao-Di Gou, Tian-Lan Zhang, Kui Wang. Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells. Cell Biol. Int. 2008; 32, 1497–1505.

11.Hai-Tao Ding, Chen-Guang Wang, Tian-Lan Zhang, Kui Wang. Fibronectin enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells via ERK pathway. J. Cell. Biochem. 2006; 99, 1343-1352.

12.Li-Yun Luo, Jian Huang, Bao-Di Gou, Tian-Lan Zhang, Kui Wang. Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by arsenic sulphide: involvement of serine/threonine protein phosphatases. Leuk. Res. 2006; 30, 1399-1405.

13.He-Ping Wang, Xiao-Jing Feng, Bao-Di Gou, Tian-Lan Zhang, Shan-Jin Xu, Kui Wang. Effects of LDL, cholesterol and their oxidized forms on the precipitation kinetics of calcium phosphates. Clin. Chem. 2003; 49，2027-2036.

14.Du, X.-L.; Zhang, T.-L.; Yuan, L.; Zhao, Y.-Y.; Li, R.-C.; Wang, K.; Yan, S. C.; Zhang, L.; Sun, H.-Z.; Qian, Z.-M., Complexation of ytterbium to human transferrin and its uptake by K562 cells. Eur. J. Biochem. 2002, 269, 6082 -6090.

15.Tian-Lan Zhang and Dou-Man Jin. A theoretical approach to the leaving ligand problem of photosubstitution reactions of hexacoordinate transition metal mixed-ligand complexes. Indian J. Chem. 2001; 40A: 793-803.

16.Tian-Lan Zhang, Yu-Xi Gao, Jing-Fen Lu and Kui Wang. Arsenite, arsenate and vanadate affect human erythrocyte membrane. J. Inorg. Biochem. 2000; 79, 195-203.