常翠芳，女，博士，1982年2月生，河南師範大學生命科學學院副教授。
基本介紹
- 中文名：常翠芳
- 出生日期：1982年2月
- 職業：教師
- 畢業院校：新疆大學
- 學位/學歷：博士
- 任職院校：河南師範大學
- 職稱：副教授
研究方向,學術成果,科研項目,代表性論文,專利成果,
研究方向
生物信息學、肝纖維化、肝再生的分子調控機理
學術成果
科研項目
國家自然科學基金項目：絲氨酸蛋白酶抑制劑III對大鼠再生肝的肝細胞增殖調控機理研究，主持
河南省自然科學基金項目：絲氨酸蛋白酶抑制劑I和III調控再生肝的肝細胞機理研究，主持
河南省自然科學基金項目：肝再生相關孤兒受體GPR50調控肝細胞增殖的蛋白組學及其作用機制研究，主持
河南省高等學校重點科研項目：SPINK1 調控大鼠正常肝細胞和肝癌細胞增殖機理的比較研究，主持
國家自然科學基金項目：一個大鼠肝再生相關的新lncRNA（rLALR1）調節肝細胞增殖的作用及機理研究，參與
國家973計畫前期研究專項：大鼠肝再生的蛋白質學研究，參與
國家973計畫前期研究專項：肝臟損傷修復與再生機制的蛋白質組學基礎研究，參與
代表性論文
ChangCF, Xie JJ, Yang QD, Yang J, Luo YR, Xi LL, Guo JL, Yang GG, Jin W, Wang GP. Serinepeptidase inhibitor Kazal type III (SPINK3) promotes BRL‐3Acell proliferation by targeting the PI3K–AKT signaling pathway. JCell Physiol. 2019 Sep 2. （生物二區）
WangGP, Guo XQ, Cheng LY, Chu PP, Chen M, Chen YH, Chang CF. An integrated analysisof the circRNA-miRNA-mRNA network reveals novel insights into potentialmechanisms of cell proliferation during liver regeneration. Artificial Cells,Nanomedicine, and Biotechnology, 2019（醫學二區）
WangGP, Chu PP, Chen M, Cheng LY, Zhao CC, Chen SS, Li XF, Yang GG, Chang CF.Osteopontin promotes rat hepatocyte proliferation both in vitro and in vivo.Artificial Cells, Nanomedicine, and Biotechnology, 2019 （醫學二區）
ChangCF, Zhao WM, Luo YR, Xi LL, Chen SS, Zhao CC, Wang GP, Guo JL, Xu CS. Serinepeptidase inhibitor Kazal type I (SPINK1) promotes BRL-3A cell proliferationvia p38, ERK, and JNK pathways. Cell Biochem Funct. 2017
ChangCF, Niu ZP, Gu NN, Zhao WM, Wang GP, Jia YF, Li DM, Xu CS. Analysis of the waysand methods of signaling pathways in regulating cell cycle of NIH3T3 attranscriptional level. BMC Cell Biology, 2015
ChangCF, Xu CS. Transcriptome atlas of aromatic amino acid family metabolism-relatedgenes in eight liver cell types uncovers the corresponding metabolic pathwaysin rat liver regeneration. Int J Biochem Cell Biol, 2010
XuCS, Chang CF. Expression profiles of the genes associated with metabolism andtransport of amino acids and their derivatives in rat liver regeneration. AminoAcids. 2008
ChangCF, Yang J, Li XF, Zhao WM, Li Y, Guo PJ, Wang GP, Xu CS. Thrombopoietinsignaling pathway regulates the hepatocytes activation in rat liverregeneration. Biochem Genet, 2015
ChangCF, Yang J, Li XF, Zhao WM, Chen SS, Wang GP, Xu CS. SPINK3: A novel growthfactor that promotes rat liver regeneration. Molecular Biology, 2016
ChangCF, Zhao WM, Yang J, Li MH, Zhou Y, Xu CS. Study on activity of the signalingpathways regulating hepatocyte differentiation during rat liver regeneration.Anim Cells Syst, 2014
ChangCF, Xu CS. Transcriptome atlas of glutamine family amino acidmetabolism-related genes in eight regenerating liver cell types. Cell Biol Int,2010
ChangCF, Fan JY, Zhang FC, Ma J, Xu CS. Transcriptome atlas of eight liver celltypes uncovers effects of histidine catabolites on rat liver regeneration. JGenet, 2010
ChangCF, Yang J, Zhao WM, Li Y, Guo PJ, Li MH, Zhou Y, Xu CS. Gene expressionprofiling analysis of 5-hydroxytryptamine signaling pathway in rat regeneratingliver and different types of liver cells. Genet Mol Res, 2015
ChangCF, Zhao WM, Mei JX, Zhou Y, Pan CY, Xu TT, Xu CS. Branches of NF-κb signalingpathway regulate hepatocyte proliferation in rat liver regeneration. Genet MolRes, 2015
GengXF, Chang CF, Zang XY, Sun JY, Li PF, Guo JL, Xu CS. Integrative proteomic andmicroRNA analysis of the priming phase during rat liver regeneration. Gene,2016
DingY, Chang CF, Niu ZP, Dai KQ, Geng XF, Li DM, Guo JL, Xu CS. Overexpression ofTranscription Factor Foxa2 and Hnf1α induced Rat Bone Mesenchymal Stem Cellsinto Hepatocyte. Cytotechnology, 2016
專利成果
1.基於OPN基因誘導的肝細胞體外增殖方法
2. 一種表達人血清白蛋白的質粒和重組菌以及它們的套用
3. 表達人血清白蛋白的質粒和重組菌以及它們的套用
