尹燁

尹燁

尹燁,華大基因CEO。哥本哈根大學博士,基因組學研究員,大連理工大學兼職教授,第三屆中國人類遺傳資源管理專家組成員,中國計量測試學會生物計量專業委員會委員,深圳市標準化協會第七屆理事會會長,第四批國家“萬人計畫”科技創業領軍人才。

他熱愛生命科學,做研究、發論文、惜人才、重團隊,曾任華大科技總裁、華大集團營運長(COO)、華大醫學總裁。

他是“非典”科研攻關主要參與者之一,曾當選最年輕的中國傑出質量人、華大基因全球化布局推動者、華大基因收購CG項目核心成員、率領華大基因成功登入創業板。

2018年1月,他在JP Morgan會議上率先發布個人全基因組測序正式進入百元美金時代、同時發布解密所有5000種哺乳動物基因組的“生命周期表計畫”。

他心繫公益事業,組建面向罕見病群體的機構“同病相聯”,和團隊一起成立救助遺傳病的“華基金”“光基金”,帶領團隊發起多項罕見病救助計畫,並主導“科技援藏暨超低溫冰櫃運送活動”。

他是媒體圈、財經圈、科研圈最受歡迎的生物界“名嘴”,也是傳播生命科學的科普工作者。開設“天方燁談”電台節目,受邀出席WIRED、TEDx、一席、中國企業家論壇等媒體活動,為講述大眾“聽得懂的生命科學”。

基本介紹

  • 中文名:尹燁
  • 國籍:中國
  • 民族:滿族
  • 出生地:遼寧丹東(籍貫山東煙臺)
  • 出生日期:1979年
人物經歷,公益實踐,獲獎記錄,主要論文,

人物經歷

2002年本科畢業後,尹燁加入華大集團(以下簡稱:華大)子公司——北京華大吉比愛生物技術有限公司,先後從事體外診斷試劑研發、產品註冊、生產管理、質量管理、市場行銷等工作,在生物產品研發、生產、質控、申報註冊及生物技術臨床套用推廣等方面有豐富的經驗,主持申報數十項體外診斷試劑及多項專利,對於GMP/IVD/ISO系列質量管理體系有深刻理解。
2003年春,尹燁作為“非典型性肺炎”(SARS)早期診斷科研攻關的主要參與者之一,在華大高效完成SARS病毒測序和獲得診斷蛋白之後,率領團隊在24小時內即完成了SARS診斷試劑盒研發及申報材料的準備,並順利獲得了國藥局(現食藥總局)的審批。隨後,華大及時將30萬人份SARS檢測試劑盒無償捐贈給國家非典防治指揮部,對疫情的防控起到了關鍵性作用。
2009年,尹燁調入華大集團深圳總部,負責基因組學及生物信息學全球範圍內的產業推廣,並先後出任華大基因科技合作事業部總裁、全球基因組平台負責人、華大生命科學研究院助理院長、華大集團營運長、華大醫學執行總裁等職。
2010年起,他開始組建華大全球行銷團隊,打造華大全球化科研、產業平台,完成了華大的全球化布局。期間,尹燁主持或參與了上百個國際基因組合作項目,包括“千種動植物基因組計畫”“百萬人重測序計畫”“蒙古族人基因組計畫”等大型項目,在Nature系列、SciencePNAS等國際頂級學術期刊發表近60篇論文(詳見主要論文部分),並促成華大與全球生命科學相關領域的機構建立良好的合作關係,為推動基因組學研究、分子育種、醫療健康、環境能源等領域的科研發展做出重要貢獻。
2013年,尹燁作為核心成員,參與完成華大對美國上市公司Complete Genomics的全資收購。
2014年,尹燁出任華大醫學執行總裁,全面貫徹“5P醫學”理念,降低出生缺陷及減少腫瘤等重大疾病對人類健康的危害,推動全球基因檢測的臨床套用發展。
2017年7月14日,深圳華大基因股份有限公司在創業板上市,成為中國基因科技第一股。目前,尹燁任深圳華大基因股份有限公司CEO,率領團隊積極推動前沿生物技術和基因組學研究成果的產業化套用,向全球頂尖的醫療機構、科研機構、大學、藥廠、育種公司等提供完整的基因組學解決方案,為臨床行為提供診斷、干預和治療依據,為生命科學及醫學創新提供技術和研究服務,和團隊一起致力於使華大基因成為全球基因科技、臨床套用的行業領導者。

公益實踐

在尹燁的帶領下,華大基因一直積極踐行改善人類健康的社會責任,心繫公益事業。他與團隊發起“生命周期表”等項目及活動,長期支持中國罕見病發展中心等罕見病專業組織,帶領團隊發起並組建“同並相聯”網站,以期打造成為罕見病、遺傳病診治與交流第一平台。與團隊多次發起罕見病救助項目,致力於推動對罕見病、血液疾病的關愛與救助。
尹燁個人亦帶頭捐款發起成立公益基金——華基金,永久免費為重症地貧患兒提供HLA配型;牽頭髮起成立“愛之光眼病基因檢測”“光基金”,意在免費提供基因檢測救助先天性眼疾的患者;發起成立“狂犬病科研基金”等專項基金,旨在推進狂犬病治療的臨床研究。
尹燁積極參與基因科普工作,多次受邀在WIRED、TEDx、一席、中國企業家論壇、亞布力企業家論壇、中歐EMBA、長江EMBA、北大EMBA、湖南衛視《我是未來》、混沌研習社、黑馬營、科技部人才中心、深圳市市民大講堂等平台授課,並在喜馬拉雅FM、懶人聽書等新媒體開設“天方燁談”基因科普欄目,通過多種渠道和途徑、上百集節目、上百篇文章,講大眾聽得懂的生命科學,宣傳、推廣與廣大人民民眾相關的基因技術與知識。

獲獎記錄

2019年2月入選第四批國家“萬人計畫”科技創業領軍人才
2018年12月成為深圳市標準化協會第七屆理事會會長
2018年9月獲評《財富》“中國40位40歲以下商界精英”
2018年9月獲頒第三屆民企盛典企業家公益人物
2018年3月獲評“感動深圳2018十佳愛心人物”
2017年12月獲頒“2017年21世紀中國最佳商業模式先鋒人物獎”
2017年11月獲頒“2017中國上市公司口碑榜最佳上市公司領袖獎”
2017年5月獲評十大“深圳好青年”
2017年4月成為科技部第三屆人類遺傳資源管理專家組成員
2017年1月獲評“深圳市國家級領軍人才”
2017年1月獲“2016年度公益人物獎”
2016年12月獲“中國傑出質量人(全國質量獎個人獎)”
2016年12月任中國計量測試學會生物計量專業委員會委員
2016年11月獲“2016時代深士”稱號
2016年7月獲“深圳市鹽田區優秀共產黨員”榮譽稱號
2015年11月被大連理工大學聘請為兼職教授
2015年9月獲“第二屆國際罕見病大會貢獻獎”
2015年4月獲大連理工大學“2014校友年度人物”獎
2015年獲“深圳市科技進步獎”
2014年12月獲深圳市企業首席質量官
2014年9月獲“2014中國十大經濟潮流人物獎”
2013年9月獲評“深圳市鹽田區生物產業高層次人才”

主要論文

  1. Wang X, Wang H, Wang J,…, Yin Y…, Brassica rapa Genome Sequencing Project Consortium. (2011) The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics. 2011 Aug 28;43(10):1035-9.
  2. 岳桂東,高強,羅龍海,王軍一,許嬌卉,尹燁(2012) 高通量測序技術在動植物研究領域中的套用.中國科學,42(2): 107-124.
  3. Gao Q, Yue GD, Li WQ, Wang JY, Xu JH, Yin Y. (2012) Recent progress using high-throughput sequencing technologies in plant molecular breeding. Journal of Integrative Plant Biology, 54(4):215-27.
  4. Qiu Q, Zhang G, Ma T,…, Yin Y, ….(2012) The yak genome and adaptation to life at high altitude. Nature Genetics. 2012 Jul 1;44(8):946-9.
  5. Kunbo Wang, Zhiwen Wang, Fuguang Li, …, Ye Yin,…. (2012) The draft genome of a diploid cotton Gossypium raimondii. Nature Genetics. 2012 Aug 26; 44(10):1098–1103
  6. Zhang G, Fang X, Guo X, …, Yin Y, Wang J. (2012) The oyster genome reveals stress adaptation and complexity of shell formation.Nature. 2012 Oct 4;490(7418):49-54.
  7. David M Altshuler, Richard M Durbin, Goncalo R Abecasis...Yin Y...(2012)An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 November 1; 491(7422): 56–65.
  8. Shaogui Guo, Jianguo Zhang, Honghe Sun, …, Ye Yin, ….(2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nature Genetics. 2012 Nov 25; 45(1):51–58
  9. Yin Y, Yue GD, Gao Q, Wang ZY,... (2012) Genome Sequence of Pedobacter arcticus sp. nov., a Sea Ice Bacterium Isolated from Tundra Soil. Journal of Bacteriology, 2012 Dec;194 (23):6688.
  10. Qixiang Zhang, Wenbin Chen, Lidan Sun, …,Ye Yin, …(2012) The genome of Prunus mume.Nature Communications, 2012,DOI: 10.1038/ncomms2290
  11. Xiangjiang Zhan, Shengkai Pan, Junyi Wang, …, Ye Yin, …(2013) Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle.Nature Genetics. 2013 March 24;45(5): 563–566
  12. Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa,…, Ye Yin, Bronwen Aken, Guojie Zhang& Naoki Irie.(2013) The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics. 2013 April28;10.1038/ng.2615
  13. Jinfeng Chen, Quanfei Huang, Dongying Gao...Ye Yin...(2013)Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution. Nature Communications, 2013, DOI: 10.1038/ncomms2596
  14. Yabin Chen, Qingyan Zhang,Tao Shen … ,Ye Yin, …. (2013)Comprehensive mutation analysis by whole-exome sequencing in 41 Chinese families with Leber congenital amaurosisInvest . Ophthalmol Vis Sci. 2013 May 9(共同作者)
  15. Huang L1, Zhang Q, Li S, Guan L, Xiao X, Zhang J, Jia X, Sun W, Zhu Z, Gao Y, Yin Y, Wang P, Guo X, Wang J, Zhang Q.(2013) Exome sequencing of 47 chinese families with cone-rod dystrophy: mutations in 25 known causative genes. PLoS One. 2013 Jun 11; 8(6):e65546.
  16. Xiaosen Guo, Max Brenner, Xuemei Zhang, ..., Ye Yin, ... (2013) Whole-Genome Sequences of DA and F344 Rats with Different Susceptibilities to Arthritis,Autoimmunity, Inflammation and Cancer. Genetics, August 2013, 194(4):1017-28
  17. Zhang C1, Li D, Zhang J,..., Yin Y, ....(2013)Mutations in ABCB6 cause dyschromatosis universalis hereditaria. J Invest Dermatol. 2013 Sep;133(9):2221-8.
  18. Tao Ma,Junyi Wang,Gongke Zhou, … ,Ye Yin, …(2013) Genomic insights into salt adaptation in a desert poplar. Nature Communications,2013, doi:10.1038/ncomms3797.
  19. Xiao JH, Yue Z, Jia LY, ..., Yin Y...(2013)Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology,2013,14:R141 doi:10.1186
  20. Cheng Qin, Changshui Yu, Yaou Shen, …, Ye Yin, Jiping Yu, Kailin Hu, and Zhiming Zhang.(2014) Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. PANS, 2014,doi/10.1073/pnas.1400975111
  21. Udpa N, Ronen R, Zhou D,..., Yin Y...(2014)Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biology. 2014 Feb 20;15(2):R36.
  22. Shiqiang Li, Liping Guan, Shaohua Fang, ..., Ye Yin, ...(2014) Exome sequencing reveals CHM mutations in six families with atypical choroideremia initially diagnosed as retinitis pigmentosa. International Journal of Molecular Medicine,2014 June 6, DOI: 10.3892
  23. Xu Y1, Guan L, Shen T, ..., Yin Y, Guo X, Wang J, Zhang Q.(2014) Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing. Hum Genet. 2014 Jun 18.
  24. Su Z, Labaj PP, Li S, ..., Yin Y, ... (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology. 2014 Sep; 32(9):903-14.
  25. Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh...Ye Yin,...(2014)Camelid genomes reveal evolution and adaptation to desert environments. Nature Communications. 21 October 2014, doi:10.1038/ncomms6188.
  26. Haihua Bai, Xiaoshen Guo, Dong Zhang, ... Ye Yin,...(2014)The genome of a mongolian individual reveals the genetic imprints of mongolians on modern human populations.Genome Biology and Evolution. 5 November 2014, 6(12):3122-3136
  27. Xiangyu Ma, Liping Guan, Wei Wu,...Ye Yin, ...(2015) Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. Scientific Report. 2015 Mar 18;5:9236. doi: 10.1038/srep09236.
  28. Zhang H1, Gao Y, Jiang F,...Yin Y,...(2015)Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146 958 pregnancies. Ultrasound Obstet Gynecol. 2015; 45: 530–538.Published online 8 April 2015 in Wiley Online Library . DOI:10.1002/uog.14792.
  29. W J, Wen J, Li J,...Yin Y,...(2003) Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clinical Chemistry. 2003 Dec;49(12):1989-96.
  30. Khurana E, Fu Y, Colonna V,...Yin Y,... (2013) Integrative annotation of variants from 1092 humans: application to cancer genomics. Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587.
  31. Yu X, Jin T, Cui Y,...Yin Y,... (2014) Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics. Journal of Virology. 2014 Mar;88(6):3423-31. doi: 10.1128/JVI.02059-13. Epub 2014 Jan 8.
  32. Huerta-Sánchez E, Jin X, Asan,...Yin Y,... (2013) Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014 Aug 14;512(7513):194-7. doi: 10.1038/nature13408. Epub 2014 Jul 2.
  33. Cai N, Chang S, Li Y1,...Yin Y,... (2015) Molecular signatures of major depression. Current Biology.2015 May 4;25(9):1146-56. doi: 10.1016/j.cub.2015.03.008. Epub 2015 Apr 23.
  34. Bäckhed F, Roswall J, Peng Y,...Yin Y,... (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe. 2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.
  35. Xu Y, Guan L, Xiao X,...Yin Y,... (2015) Mutation analysis in 129 genes associated with other forms of retinal dystrophy in 157 families with retinitis pigmentosa based on exome sequencing. Molecular Vision. 2015 Apr 28;21:477-86. eCollection 2015.
  36. Xu Y, Guan L, Xiao X,...Yin Y,... (2015) ALMS1 null mutations: a common cause of Leber congenital amaurosis and early-onset severe cone-rod dystrophy. Clinical Genetics. 2015 May 22. doi: 10.1111/cge.12617.
  37. Zhang W, Yu Y, Hertwig F,...Yin Y,... (2015)Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.Genome Biology. 2015 Jun 25;16:133. doi: 10.1186/s13059-015-0694-1.
  38. Li J, Gao B, Guan L,...Yin Y,... (2015) Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1. Investigative Ophthalmology & Visual Science. 2015 Jun;56(6):4150-5. doi: 10.1167/iovs.14-16356.
  39. Cai N, Bigdeli TB, Kretzschmar W,...Yin Y,... (2015) Sparse whole-genome sequencing identifies two loci for major depressive disorder.Nature. 2015 Jul 30;523(7562):588-91. doi: 10.1038/nature14659. Epub 2015 Jul 15.
  40. Zhang X, Zhang D, Jia H,...Yin Y,... (2015) The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.Nature Medicine.2015 Aug;21(8):895-905. doi: 10.1038/nm.3914. Epub 2015 Jul 27.
  41. 1000 Genomes Project Consortium, Auton A, Brooks LD... (2015) A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393.
  42. Sudmant PH, Rausch T, Gardner EJ,...Yin Y,... (2015)An integrated map of structural variation in 2,504 human genomes. Nature. 2015 Oct 1;526(7571):75-81. doi: 10.1038/nature15394.
  43. Li C, Gao Z, Li F, Li X,...Yin Y,... (2015) Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.Scientific Reports.2015 Oct 27;5:14237. doi: 10.1038/srep14237.
  44. Xu Y1, Guan L, Xiao X,...Yin Y,... (2015) Identification of MFRP Mutations in Chinese Families with High Hyperopia. Optometry & Vision Science.2016 Jan;93(1):19-26. doi: 10.1097/OPX.0000000000000751.
  45. Delaneau O, Marchini J; 1000 Genomes Project Consortium.(2014) Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.Nature Communications.2014 Jun 13;5:3934. doi: 10.1038/ncomms4934.
  46. Colonna V, Ayub Q, Chen Y,...1000 Genomes Project Consortium,... (2014) Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.Genome Biology.2014 Jun 30;15(6):R88. doi: 10.1186/gb-2014-15-6-r88.
  47. Jun Wang,Lachlan J.M. Coin,Lin Fang,...,Ye Yin,...(2016)Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nature Genetics.10.1038/ng.3559.
  48. 黃輝,陳冬娜,吳靜,尹燁(2016)高通量測序技術在罕見病分子診療中的套用及臨床實例分析,藥學進展.40(6):420-428.
  49. Jingmei Ma,Yicong Wang,Weipeng Wang,...,Ye Yin,...(2016)Validation of combinatorial probe-anchor ligation (cPAL) based sequencing method for non-invasive prenatal testing in trisomy detection by a central laboratory.Ultrasound in Obstetrics & Gynecology. 10.1002/uog.16010.
  50. Wen Xie,Chunhai Chen,Zezhong Yang,...,Ye Yin,...(2017)Genome sequencing of the sweetpotato whitefly Bemsia tabaci MED/Q.Giga Science. 10.1093/gigascience/gix018.
  51. YuLing Lin,JiuMeng Min,RuiLian Lai,...,Ye Yin,...(2017)Genome-wide sequencing of longan (Dimocarpus longan Lour.) provides insights into molecular basis of its polyphenol-rich characteristics.Giga Science.10.1093/gigascience/gix023.
  52. Yuanyuan Li,Miki Ohira,Yong Zhou,...,Ye Yin,...(2017)Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.Oncotarget. 10.18632/oncotarget.18079.
  53. Alex Harkess, Jinsong Zhou, Chunyan Xu, ...,Ye Yin,...(2017)The asparagus genome sheds light on the origin and evolution of a young Y chromosome.Nature Communications.10.1038/s41467-017-01064-8.
  54. Xuan Shang,Zhiyu Peng,Yuhua Ye,...,YeYin,(2017)Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies.EBioMedicine.10.1016/j.ebiom.2017.08.015.
  55. Yueqiang Wang,Yue Shen,Ying Gu,Shida Zhu,Ye Yin. (2018) Genome Writing Current Progress and Related Applications.Genomics Proteomics & Bioinformatics. 10.1016/j.gpb.2018.02.001.
  56. Linhuan Wu, Kevin McCluskey, Philippe Desmeth, ..., Ye Yin, ... (2018) The Global Catalogue of Microorganisms 10K type strain sequencing project.GigaScience. 10.1093/gigascience/giy026.
  57. Chaoling Wei, Hua Yang, Songbo Wang,..., Ye Yin, ... (2018)Draft genome sequence of Camellia sinensis var. sinensis provides insights into the evolution of the tea genome and tea quality. Proceedings of the National Academy of Sciences of the United States of America. 10.1073/pnas.1719622115.
  58. Wensheng Wang, Ramil Mauleon, Zhiqiang Hu, ..., Ye Yin, ...(2018) Genomic variation in 3010 diverse accessions of Asian cultivated rice. Nature.10.1038/s41586-018-0063-9.
  59. Mingzhi Ye, Shiyong Li, Weizhe Huang,..., Ye Yin, ... (2018)Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules.Journal of thoracic disease.10.21037/jtd.2018.04.09.

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