安磊，男，博士，中國農業大學動物科學技術學院教授、碩士生導師。
基本介紹
- 中文名：安磊
- 畢業院校：中國農業大學
- 學位/學歷：博士
- 任職院校：中國農業大學
人物經歷,學習經歷,工作經歷,社會兼職,研究方向,教學工作,學術成果,承擔項目,發表論文,發明專利,獲得榮譽,
人物經歷
學習經歷
2000.09-2004.06：山西農業大學動物科技學院，獲店堡乃農學學士學位；
2004.09-2010.06：中國農業大學動物科技學院，獲農學博士學位。
工作經歷
2010.07-2013.12：中國農業大學，動物科技學院，講師；
2014.01-2018.11：中國農業大學，動物科技學院，副教授，碩士生導師。
2018.11-至今： 中鞏盼陵國農業大學，動物科技學院再境犁，教授。
社會兼職
畜牧獸醫學會繁殖學分會理事
研究方向
以建立家畜配子胚胎高效利用技術為目標，主要研究家畜配子和胚胎髮育調控機制，重點關注體外受精（IVF）胚胎髮育異常的表觀調控機制，突破家畜體外胚胎生產的關鍵技術瓶頸。
教學工作
承擔本科生與研究生教學課程等
本科教學課程：動物繁殖學實驗
研究生教學課程：動物繁殖與胚胎工程技術實踐、動物分子繁殖與發育理論、動物分子繁殖與發育理論
學術成果
承擔項目
自然閥歸欠戲基金面上項目“C型鈉肽在腔前卵泡成腔啟動中的關鍵作用研究”（主持）2017.01-2020.12
“笑照863”課題“羊重要經濟性狀功能基因組學研究”（主持子課題）2013.01-2017.12
支撐計畫課題“豬牛繁殖障礙控制”（主持子課題），2011.01-2014.12
“863”課題“動物胚胎表觀修飾及體細胞克隆技術研究”課題（參加），2011.01-2015.12
國家自然基金面上項目，體外胚胎出龍炒譽生性別比例失衡的分子機奔霸洪享制研究（參加）2015.01-2018.12
發表論文
Tan K,An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A 2016; 113:3197-3202(co-first author)
Tan K., Wang X., Zhang Z., Miao K., Yu Y.,An L*., and Tian JH.*, Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts. Biol Reprod (2016, in press online)
Tan K, Wang Z, Zhang Z,An L*,Tian JH*. IVF affects embryonic development in a sex-biased manner in mice. Reproduction 2016; 151:443-53.
L. Tao, M. Yang, X. Wang, Z. Zhang, Z. Wu, J. Tian,L. An *, and S. Wang*, Efficient biallelic mutation in porcine parthenotes using a CRISPR-Cas9 system. Biochem Biophys Res Commun 476 (2016) 225-9.
Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J,An L*. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod 2016. 22; 485-98
Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z,Lei A*. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev 2016.
Sui L,An L, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J*. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod 2014; 91: 155.(co-first author)
Nie J,An L, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Lei X, Wu Z, Tian J*. Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during postimplantation period. J Proteome Res 2013; 12:3843-3856. (co-first author) 5
Wang, Y., Wang, C., Hou, Z., Miao, K., Zhao, H., Wang, R., Guo, M., Wu, Z., Tian, J.,An, L*., 2013. Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J Anim Sci Biotechnol 4, 39. 2
Pang YW,An L, Wang P, Yu Y, Yin QD, Wang XH, Xin-Zhang, Qian-Zhang, Yang ML, Min-Guo, Wu ZH, Tian JH*. Treatment of porcine donor cells and reconstructed embryos with the antioxidant melatonin enhances cloning efficiency. J Pineal Res 2013; 54: 389-397. (co-first author) 5
An L,Pang YW, Gao HM, Tao L, Miao K, Wu ZH, Tian JH. Heterologous expression of C. elegans fat-1 decreases the n-6n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun 2012; 428: 405-410. 3
Ma W,An LWu Z, Wang X, Guo M, Miao K, Ma W, Tian J*. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. Biol Reprod 2011; 85: 670-677. (co-first author) 10
An L,Wu ZH, Wu YF, Zhang XL, Liu X, Zhu YB, Cheng WM, Gao HM, Guo M, Tian JH*. Fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm. Reprod Domest Anim 2010; 45: e344-e350. 9
Cheng WM,An L,Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH*. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction 2009; 137: 633-643. (co-first author) 9
發明專利
Method for inducing twin calving. US 20140349934A1 （國際發明專利）
C型鈉肽在促進牛卵母細胞體外成熟中的套用ZL201210348285.9
來曲唑在用於製備成年牛超數排卵藥物中的套用ZL201110436200.8
來曲唑在製備激素誘導犢牛卵泡發育藥物中的套用ZL201110434833.5
一種豬用子宮深部低劑量輸精器械及其輸精器的端部探伸構造ZL201220721931.7
一種製備奶牛性別控制精子的方法ZL201110059938.7
一種消化卵母細胞透明帶的方法ZL200610012029.7
獲得榮譽
2011年參與專業碩士學位課“動物繁殖技術進展與實踐”課程建設，獲校級優秀課程；
2013年參與“家畜繁殖學”課程建設，獲國家級精品資源共享課；
2010-2014擔任動科102班班主任，班級先後獲得 “北京市先進班集體”、校級“優良學風班” 、“優秀團支部”等稱號；
2014年指導本科畢業設計獲得校級優秀論文；
2015年學院優秀黨員;
2016年“大北農青年學者獎”。
2017年9月19日，中央人才工作協調小組辦公室發布《第三批國家“萬人計畫”青年拔尖人才建議人選名單》，中國農業大學安磊入選。
Tan K, Wang Z, Zhang Z,An L*,Tian JH*. IVF affects embryonic development in a sex-biased manner in mice. Reproduction 2016; 151:443-53.
L. Tao, M. Yang, X. Wang, Z. Zhang, Z. Wu, J. Tian,L. An *, and S. Wang*, Efficient biallelic mutation in porcine parthenotes using a CRISPR-Cas9 system. Biochem Biophys Res Commun 476 (2016) 225-9.
Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J,An L*. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod 2016. 22; 485-98
Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z,Lei A*. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev 2016.
Sui L,An L, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J*. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod 2014; 91: 155.(co-first author)
Nie J,An L, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Lei X, Wu Z, Tian J*. Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during postimplantation period. J Proteome Res 2013; 12:3843-3856. (co-first author) 5
Wang, Y., Wang, C., Hou, Z., Miao, K., Zhao, H., Wang, R., Guo, M., Wu, Z., Tian, J.,An, L*., 2013. Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J Anim Sci Biotechnol 4, 39. 2
Pang YW,An L, Wang P, Yu Y, Yin QD, Wang XH, Xin-Zhang, Qian-Zhang, Yang ML, Min-Guo, Wu ZH, Tian JH*. Treatment of porcine donor cells and reconstructed embryos with the antioxidant melatonin enhances cloning efficiency. J Pineal Res 2013; 54: 389-397. (co-first author) 5
An L,Pang YW, Gao HM, Tao L, Miao K, Wu ZH, Tian JH. Heterologous expression of C. elegans fat-1 decreases the n-6n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun 2012; 428: 405-410. 3
Ma W,An LWu Z, Wang X, Guo M, Miao K, Ma W, Tian J*. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. Biol Reprod 2011; 85: 670-677. (co-first author) 10
An L,Wu ZH, Wu YF, Zhang XL, Liu X, Zhu YB, Cheng WM, Gao HM, Guo M, Tian JH*. Fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm. Reprod Domest Anim 2010; 45: e344-e350. 9
Cheng WM,An L,Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH*. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction 2009; 137: 633-643. (co-first author) 9
發明專利
Method for inducing twin calving. US 20140349934A1 （國際發明專利）
C型鈉肽在促進牛卵母細胞體外成熟中的套用ZL201210348285.9
來曲唑在用於製備成年牛超數排卵藥物中的套用ZL201110436200.8
來曲唑在製備激素誘導犢牛卵泡發育藥物中的套用ZL201110434833.5
一種豬用子宮深部低劑量輸精器械及其輸精器的端部探伸構造ZL201220721931.7
一種製備奶牛性別控制精子的方法ZL201110059938.7
一種消化卵母細胞透明帶的方法ZL200610012029.7
獲得榮譽
2011年參與專業碩士學位課“動物繁殖技術進展與實踐”課程建設，獲校級優秀課程；
2013年參與“家畜繁殖學”課程建設，獲國家級精品資源共享課；
2010-2014擔任動科102班班主任，班級先後獲得 “北京市先進班集體”、校級“優良學風班” 、“優秀團支部”等稱號；
2014年指導本科畢業設計獲得校級優秀論文；
2015年學院優秀黨員;
2016年“大北農青年學者獎”。
2017年9月19日，中央人才工作協調小組辦公室發布《第三批國家“萬人計畫”青年拔尖人才建議人選名單》，中國農業大學安磊入選。
