夏朋延

夏朋延，男，博士，北京大學基礎醫學院免疫系研究員、博士生導師。

基本介紹

  • 中文名：夏朋延
  • 畢業院校：中國科學院大學
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：生物化學與分子生物學
  • 任職院校：北京大學
研究方向,個人經歷,榮譽獎項,學術成果,

研究方向

1．發現新的模式識別受體、鑑定新的特徵性病原分子；2．探索天然免疫反應在造血幹細胞發育分化過程中的調節作用、鑑定新的免疫細胞亞群。

個人經歷

2004/9–2008/6武漢大學生命科學學院學習，獲得理學學士學位；2008/9–2014/6中國科學院大學學習，獲得生物化學與分子生物學專業理學博士學位。2014/7–2015/11在中國科學院生物物理研究所從事博士後研究，並於2015/12獲評中國科學院生物物理研究所副研究員。2018年12月加入北京大學基礎醫學院免疫系，擔任研究員職務、博士生導師。

榮譽獎項

2013年國家獎學金，2016年中國科學院優秀博士論文

學術成果

近年發表的研究論文：
  1. Xia P,Wang S, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z. Circular RNA cia-cGAS protects dormant hematopoietic stem cells from cGAS-mediated exhaustion.Immunity2018
  2. Xia P,Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y, Fan Z. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity.Nat. Immunol.2018
  3. Wang S#,Xia P#,Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z. Regulatory innate lymphoid cells control innate intestinal inflammation.Cell2017. (#co-first authors)
  4. Xia P,Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y, Fan Z. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.Nat. Immunol.2016
  5. Xia P,Wang S, Ye B, Du Y, Huang G, Zhu P, Fan Z. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.Nat. Immunol.2015
  6. Wang S#,Xia P#,Chen Y#,Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan Z. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection.Immunity2016(#co-first authors)
  7. Wang S#,Xia P#,Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.Cell stem cell2013(#co-first authors)
  8. Xia P,Liu J, Wang S, Ye B, Du Y, Xiong Z, Han ZG, Tong L, Fan Z. WASH maintains NKp46ILC3 cells by promoting AHR expression.Nat. Commun.2017
  9. Xia P,Wang S, Du Y, Huang G, Satoh T, Akira S, Fan Z. Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.J. Exp. Med.2015
  10. Xia P,Wang S, Xiong Z, Ye B, Huang LY, Han ZG, Fan Z. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.Nat. Commun.2015
  11. Xia P,Wang S, Huang G, Zhu P, Li M, Ye B, Du Y, Fan Z. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.J. Exp. Med.2014
  12. Xia P,Wang S, Huang G, Du Y, Zhu P, Li M, Fan Z. RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.Cell Res.2014
  13. Xia P,Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.EMBO J.2013
  14. Wang S#,Xia P#,Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity.Nat. Commun.2016(#co-first authors)
  15. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C,Xia P,Zhang G, Tian Y, Chen R, Fan Z. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling.Cell stem cell2015
  16. Ye B, Liu B, Yang L, Huang G, Hao L,Xia P,Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.Nat Commun.2017
  17. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X,Xia P,Ye B, Wang S, Hao L, Wu J, Fan Z. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.J. Clin. Invest.2015
  18. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S,Xia P,Huang G, Sun L, Tian Y, Fan Z. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.J. Exp. Med.2014
  19. Li M,Xia P,Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li P, Yang X, Fan Z. T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-gamma production of natural killer cells via beta-arrestin 2-mediated negative signaling.J. Biol. Chem.2014
  20. Yang X, Xu M, Wang Y,Xia P,Wang S, Ye B, Tong L, Jiang T, Fan Z. Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae.Acta Crystallogr D Biol Crystallogr.2014
  21. Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S,Xia P,Yang X, Kuwahara K, Sakaguchi N, Fan Z. Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.Stem Cells2014
  22. Wang S,Xia P,Shi L, Fan Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade.Cell Death Differ.2012
  23. Huang L, Zhu P,Xia P,Fan Z. WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.Cell Death Dis.2016
受邀請綜述及書籍：
  1. Xia P,Wang S, Fan Z. DNA sensor cGAS mediates immune recognition.Protein & Cell2016Xia P,Wang S, Fan Z. Research progress on autophagy and immunity.Chinese Bulletin of Life Sciences 2016
  2. Wang S,Xia P,Rehm M, Fan Z. Autophagy and cell reprogramming.Cell. Mol. Life Sci.2015;
  3. Xia P,Wang S, Fan Z. Chapter 24: Progress on autophagy and immunity.Immunological progress.2014 (3edition)

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