人物履歷
本碩博就讀於東南大學生物科學與醫學工程學院;
2011年,獲工學博士學位;
2024年,任東南大學生物科學與醫學工程學院院長;
研究方向
1.DNA測序技術(高通量測序,單細胞測序,單分子測序等)
2.生物信息學(基因組、轉錄組分析,測序信息學等)
3.核酸分析技術(基因晶片,微流控系統,納米孔感測器等)
主要成就
研究成果
主持國家重點研發計畫課題1項,主持國家自然科學基金項目4項,主持省部級項目及其他項目6項,作為項目骨幹參與多項國家重點研發計畫、科技部973計畫、國家重大科研儀器研製專項等重要科研項目。以第一作者/通訊作者在Nature Communications、Cell genomics和Nucleic Acids Research等知名期刊發表SCI論文近50餘篇,獲國家發明專利授權10餘件。擔任Nature Aging、Bioinformatics和Lab on a Chip等國際學術期刊審稿人。
指導江蘇省優秀本科畢業論文2篇、江蘇省優秀本科畢業論文團隊1支,指導東南大學優秀碩士學位論文1篇,3名研究生入選江蘇省研究生培養創新工程。
代表論文
1. Lu N, Qiao Y, An PF, Luo JJ, Bi CW, Li MS, Lu ZH*, Tu J*: Exploration of whole genome amplification generated chimeric sequences in long-read sequencing data. Briefings in Bioinformatics, 2023, Accepted.
2. Fu JY, Wu LL, Hu G, Li FY, Ge QY, Lu ZH*, Tu J*: Solid-state Nanopore Analysis on Conformation Change of DNA Polymerase I induced by DNA Substrate. Analyst, 2022, 147, 3087-3095.
3. Tu J*, Qiao Y, Xu ZY, Lu N, Long NY, Lu ZH*: dCITI-Seq: Droplet Combinational Indexed Transposon Insertion Sequencing. Analytical and Bioanalytical Chemistry, 2022, 414: 2661-2670.
4. Tu J*, Duan MQ, Liu WL, Lu N, Zhou Y, Sun X, Lu ZH*: Direct genome-wide identifying of G-quadruplex structures by whole-genome resequencing. Nature Communications, 2021, 12: 6014.
5. Huang MT, Yang YX, Wen XZ, Xu WQ, Lu N, Sun X, Tu J*, Lu ZH: Inferring single cell expression profiles from overlapped pooling sequencing data with compressed sensing strategy. Nucleic Acids Res., 2021, DOI: 10.1093/nar/gkab581 (IF 16.971).
6. Tu J*, Meng H, Wu LL, Xi GH, Fu JY, Lu ZH: EasyNanopore: A ready-to-use processing software for translocation events in nanopore translocation experiments. Langmuir, 2021, 37(33): 10177–10182.
7. Qiao Y, Liu WL, Lu N, Xu ZY, Tu J*, Lu ZH*: Cyclical concentration adjusting accelerates the time-consuming multiple displacement amplification, Anal. Chim. Acta, 2021, 1141(1): 173-179.
8. Hu G, Fu JY, Qiao Y, Meng H, Wang ZL,Tu J*, Lu ZH*: Molecular dynamics discrimination of the conformational states of Calmodulin through solid-state nanopore, Phys. Chem. Chem. Phys., 2020, 22(1), 19188-19194.
9. Fu JY, Qiao Y, Song H, Xu ZY, Tu J*, Ba L*, Lu ZH*: Advanced transferring of large-area freestanding graphene film by using fullerenes. Nanotechnology, 2019, 30(26): LT01.
10. Li JJ, Lu N, Tao YH, Duan MQ, Qiao Y, Xu YM, Ge QY, Bi CW, Fu JY, Tu J*, Lu ZH*: Accurate and sensitive single-cell-level detection of copy number variations by micro-channel multiple displacement amplification (μcMDA). Nanoscale, 2018, 10, 17933-17941.
11. Li JJ, Lu N, Shi XL, Qiao Y, Chen L, Duan MQ, Hou Y, Ge QY, Tao YH, Tu J*, Lu ZH*: 1D-reactor Decentralized MDA for Uniform and Accurate Whole Genome Amplification. Anal. Chem., 2017, 89(19), 20147-10152.