廣西大學動物科學技術學院教授，博士生導師。入選廣西高校引進海外高層次人才“百人計畫”，霍英東教育基金獲得者。
基本介紹
- 中文名：周磊
- 國籍：中國
- 職業：教師
- 學位/學歷：博士/研究生
- 專業方向：動物功能基因組
- 學術代表作：Hepatology. 2013, 57: 1384-1393
個人資料,工作經歷,研究方向,主要成就,發表論文,
個人資料
留學德國糖尿病研究中心（杜塞道夫）、法國核能署（巴黎）、美國賓夕法尼亞大學（費城）。主要研究方向包括：①營養、基因與代謝穩態；②動物肉質形成的分子基礎及其調控；③細胞分化中的編程與重編程；④動物功能基因的轉錄調控和信號轉導；⑤動物脂肪發育的分子機制及其調控。主持國家自然科學基金、廣西自然科學基金重點項目、霍英東教育基金、歐洲糖尿病研究基金、教育部留學回國人員科研啟動基金、教育部新教師基金等。在《Hepatology》、《Nucleic Acids Research》等國內外學術刊物上發表相關SCI收錄論文20餘篇。
工作經歷
2013至今，廣西大學，動物科學技術學院，教授。
2009－2013，華中農業大學，生命科學技術學院，教師。
研究方向
①營養、基因與代謝穩態；
②動物肉質形成的分子基礎及其調控；
③細胞分化中的編程與重編程；
④動物功能基因的轉錄調控和信號轉導；
⑤動物脂肪發育的分子機制及其調控。
主要成就
開展研究工作以來，主持多項國家級、國際合作和省部級項目，發表相關論文二十餘篇。圍繞以上方向開展了較為系統的基礎研究工作，取得了以下研究進展：
一、在動物整體水平上，發現抵抗素減少線粒體、增強脂肪異位沉積
二、在細胞水平上，證實脂肪細胞因子參與葡萄糖代謝、肌肉發育及炎症反應
三、在遺傳水平上，開展豬脂肪代謝相關基因的克隆及轉錄調控研究
發表論文
1. Li H, Chen A, Shu L, Yu X, Gan L, Zhou L(通訊作者), Yang Z. Translocation of CIDEC in hepatocytes depends on fatty acids.Genes Cells. 2014, 19(11): 793-802. IF: 2.855
2.Lei Zhou(通訊作者), Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Juergen Eckel, Zaiqing Yang. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 2013, 57: 1384-1393. IF: 12.003
3. Lei Zhou, Gwenaelle Le Roux, Cecile Ducrot, Stephane Chedin, Jean Labarre, Michel Riva, Christophe Carles. Repression of class I transcription by cadmium is mediated by the Protein Phosphatase 2A. Nucleic Acids Res. 2013, 41: 6087–6097. IF: 8.278
4. Lei Zhou, Lijie Zhang, Qingjie Meng, Congcong Niu, Dan Jin, An Yu, Li gan, Zaiqing Yang. C/EBPa promotes transcription of the porcine perilipin5 gene. Mol Cell Endocrinnol. 2012; 364:28-35. IF: 4.192
5. Lei Zhou, Qingjie Meng, Tao Qian, Zaiqing Yang. Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. J Nat Med. 2011; 65(1): 50-6. IF: 1.389
6. Lei Zhou, Henrike Sell, Kristin Eckardt, Zaiqing Yang, Jürgen Eckel. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS letters. 2007; 581: 4303-4308. IF: 3.263
7. Lei Zhou, Yixing Li, Tao Nie, Shengqiu Feng, Huaping Chen, Zaiqing Yang. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J BIOCHEM MOL BIOL. 2007; 40(4): 525-31. IF: 2.141
8. Lei Zhou, Tao Xia, Yixing Li, Xiaodong Chen, Yin Peng, Zaiqing Yang. Transcriptional Regulation of the Resistin Gene. Domest Anim Endocrinol. 2006; 30(2): 98-107. IF: 2.168
9. Lei Zhou, Yixing Li, Tao Xia, Shengqiu Feng, Xiaodong Chen, Zaiqing Yang. Resistin Overexpression Impaired Glucose Tolerance in Hepatocytes. Eur Cytokine Netw. 2006; 17(3): 189-95. IF: 1.216
10. 周磊，楊在清. 抗素的研究進展.《中國獸醫科學》2006; 36(08): 684-686.
11. Yanling Wu, Qinqiang Long, Bin Feng, Xiaoyue Zhu, Zifeng Zheng, Sumin Gao, Mingju Gao, Li Gan, Lei Zhou, Zaiqing Yang. Molecular cloning and characterization of the anti-obesity gene adipose in pig. Gene. 2012; 509: 110-9. IF: 2.341
12. Chen Z, Gao X, Lei T, Chen X, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z. Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011; 33(7): 1327-37. IF: 1.683
13. Zhang J, Lei T, Chen X, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z. Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation. 2010 Feb; 33(1): 25-33.IF: 1.777
14. Qi YM, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Mol Biol Rep. 2009; 36(7): 1881-8.IF: 2.038
15. Y. H. Li, T. Lei, X. D. Chen, T. Xia, Q. Q. Long, J. Zhang, S. Q. Feng, Y. Peng, L. Zhou, Z. Q. Yang. Molecular cloning, chromosomeal location and expression pattern of porcine CIDEa and CIDEc. Mol Biol Rep. 2009 Mar; 36(3): 575-82.IF: 2.038
16. Qi M, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, Characterization, Chromosomal Mapping and Tissue Transcription Analysis of Porcine CREB2 and CREB3 Genes. Folia Biol(Praha). 2009; 55(4): 137-44. IF: 1.219
17. Yixing Li，Lei Zhou, Youguo Li, Dasong Chen, Xuejuan Tan, Lei Lei and Junchu Zhou. A Nodule-Specific Plant Cysteine Proteinase, AsNODF32, Is Involved in Nodule Senescence and Nitrogen Fixation Activity of the Green Manure Legume Astragalus sinicus.New Phytologist. 2008; 180: 185-192. IF: 5.178
18. Huaping Chen, Wenshu Yao, Dan Jin, Tao Xia, Xiaodong Chen, Ting Lei, Lei Zhou, Zaiqing Yang. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochem Genet. 2008; 46(7-8): 398-405. IF: 0.75
19. Huaping Chen, Tao Xia, Lei Zhou, Xiaodong Chen, Li Gan, Wenshu Yao, Yin Peng, and Zaiqing Yang. Gene organization, alternate splicing and expression pattern of porcine visfatin gene.Domest Anim Endocrinol. 2007; 32: 235-45. IF: 2.528
20. HW Yang, T Xia, ZL Chen, SQ Feng, Y Peng, L Zhou, L Gan, and ZQ Yang. Cloning, chromosomal localization and expression patterns of porcine Kruppel-like factors 4, -5, -7 and the early growth response factor 2.Biotechnol Lett. 2007; 29(1): 157-63. IF: 1.222
21. Feng SQ, Chen XD, Xia T, Gan L, Qiu H, Dai MH, Zhou L, Peng Y, Yang ZQ. Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4. Cytogenet Genome Res. 2006; 114(1): 44-9. IF: 1.839
