吳瑩，南方醫科大學公共衛生學院生物統計學系副教授，碩導。
基本介紹
- 中文名：吳瑩
- 國籍：中國
- 專業方向：因果推斷方法；醫學大數據挖掘分析；臨床研究前沿設計方法及統計分析方法
人物經歷,研究方向,主要成就,主要發表論文,
人物經歷
2016年9月至2018年9月，同濟大學博士後。2018年9月至今，就職於南方醫科大學生物統計學系。兼任海南樂城真實世界研究院副秘書長&藥品處負責人，海南大學博士生導師，廣東省生物統計學會秘書長、中國初級衛生保健基金會醫學統計專業委員會常委、中國醫藥教育協會首醫藥慢病防治與教育工作委員會常委、廣東省食品藥品監督管理局醫療器械審評諮詢專家、中國系統工程學會醫藥衛生系統工程專業委員會委員等。長期從事藥物臨床研究及循證醫學研究，對臨床研究方案設計及統計分析有豐富經驗，參與多項由國家藥監局發布的統計學指導原則制定和撰寫工作。
研究方向
因果推斷方法；
醫學大數據挖掘分析；
臨床研究前沿設計方法及統計分析方法
主要成就
國家自然科學基金面上項目，82273732，基於適應性隨機化理論的混合臂試驗設計方法及其因果推斷模型研究，2023/01-2026/12，52萬元，主持。
國家自然科學基金青年項目，81703322，基於三臂非劣效性臨床試驗不依從問題的Bayes因果模型及評價方法研究，2018/01-2020/12，20萬元，主持。
中國博士後科學基金面上項目，一等資助，2017M610279，基於貝葉斯網路Meta分析的非劣效性評價方法及套用研究，2017/06-2018/09，8萬元，主持。
廣東省醫學科學技術研究基金項目，A2019438，基於 Bayes 因果模型的非劣效臨床試驗不依從數據評價方法研究，2019/07-2021/06，1萬元，主持。
主要發表論文
1. Ying Wu, Liang Zhao, Yan Hou, Kang Li, Xiao-Hua Zhou. Correcting for non-compliance in randomized non-inferiority trials with active and placebo control using structural models. Statistics in Medicine 2015; 34:950-965. （第一作者）
2. Ying Wu, Yiqun Li, Yan Hou, Kang Li, Xiaohua Zhou. Study duration for three-arm non-inferiority survival trials designed for accrual by cohorts. Statistical Methods in Medical Research 2016.03.17（第一作者）
3. Ying Wu, Lu Wang, Zhongyuan Cai, Luqi Bao, Pu Ai, Zisheng Ai. Prevalence and Risk Factors of Low Health Literacy: A Community-Based Study in Shanghai, China. International Journal of Environmental Research and Public Health 2017.06. DOI:10.3390/ijerph14060628. (並列一作)
4. Ying Wu, Zisheng Ai, Guotong Xu. Marital status and survival in patients with non-small cell lung cancer: an analysis of 70006 patients in the SEER database. Oncotarget 2017.10. DOI: 10.18632/oncotarget.21568. （第一作者）
5. Ying Wu, Pu Ai, Zisheng Ai, Guotong Xu. Subthreshold Diode Micropulse Laser versus Conventional Laser Photocoagulation Monotherapy or Combined with Anti-VEGF Therapy for Diabetic Macular Edema: A Bayesian Network Meta-analysis. Biomedicine & Pharmacotherapy 2018;97: 293-299. （第一作者）
6. Li YQ†, Wu Y†, Zhang XH, Bai YF, Akthar LM, Lu X, Shi M, Zhao JX, Jiang QH, Li Y* SCIA: A Novel Gene Set Analysis Applicable to Data With Different Characteristics. Front. Genet. 2019 Jun 25;10:598. (並列一作)
7. Yang K†, Wu Y†, Chen D, Liu S*, Chen R*. The Impact of Lung Function on Extra-Pulmonary Diseases and All-Cause Mortality in US Adult Population with and without COPD. Clin Epidemiol. 2020;12:997-1005
(並列一作)
8. Zhou L†, Wu Y†, Yu S, Shen Y, Ke C. Low-density lipoprotein cholesterol and all-cause mortality: findings from the China health and retirement longitudinal study. BMJ Open. 2020;10(8):e036976. Published 2020 Aug 16. doi:10.1136/bmjopen-2020-036976. (並列一作)
9. Chaofu Ke; Yanan Qiao; Siyuan Liu; Yuqi Rui; Ying Wu *. Longitudinal research on the idirectional association between depression and arthritis, Social Psychiatry and Psychiatric Epidemiology, 2021.Jul, 56(7): 1241-1247.
10. Xiaoyang Jia, Kun Zhang, Minfei Qiang, Ying Wu, Yanxi Chen. Association of Computer-Assisted Virtual Preoperative Planning With Postoperative Mortality and Complications in Older Patients With Intertrochanteric Hip Fracture. JAMA Netw Open. 2020;3(8):e205830. doi:10.1001/jamanetworkopen.2020.5830
11. Jie-Qi Jin, Yue Du, Li-Jun Xu, Zhao-Yue Chen, Jin-Jian Chen, Ying Wu, Chun-Quan Ou. Using Bayesian spatio-temporal model to determine the socio-economic and meteorological factors influencing ambient PM2.5 levels in 109 Chinese cities. Environmental Pollution, 2019; 254, Part A, 113023, ISSN 0269-7491,
12. Ke Chaofu, Li Ang, Hou Yan, Sun Meng, Yang Kai, Cheng Jinlong, Wang Jingtao, Ge Tingting, Zhang Fan, Li Qiang, Li Junnan, Wu Ying, Lou Ge, Li Kang. Metabolic phenotyping for monitoring ovarian cancer patients. Scientific Reports, 2016.3.21.
13. Wei Hai-bo, Lu Xiang-shi, Shang Li-hua, Xu Gang, Hu Jing, Che De-hai, Liu Fang, Wu Ying, Zhang Guang-mei, Yu Yan, Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T Predict Outcome of Platinum-based Chemotherapies in Advanced Non-small Cell Lung Cancer: A Meta-analysis. ARCHIVES OF MEDICAL RESEARCH, 2011.7.01;42(5): 412~420.
14. Zhao R, Duan X, Wu Y, Zhang Q, Chen Y. Association of exposure to Chinese famine in early life with the incidence of hypertension in adulthood: A 22-year cohort study. Nutr Metab Cardiovasc Dis. 2019; 29(11): 1237-1244. doi:10.1016/j.numecd.2019.07.008.
15. Liu S, Qiao Y, Zhang Y, Wu Y, Ke C, Shen Y. Combined effect of high depressive symptom burden and hypertension on new-onset stroke: evidence from a nationwide prospective cohort study [published online ahead of print, 2020 Jul 27]. J Hypertens. 2020;10.1097/HJH.0000000000002599. doi:10.1097/HJH.0000000000002599.
16. Zhang, Y., Zhou, L., Liu, S., Qiao, Y., Wu, Y., Ke, C., & Shen, Y. (2020). Prevalence, correlates and outcomes of multimorbidity among the middle-aged and elderly: Findings from the China Health and Retirement Longitudinal Study. Archives of gerontology and geriatrics, 90, 104135.
17. 吳瑩, 侯艷, 李康. 臨床試驗中生存分析的非劣效研究設計及R軟體實現, 中國衛生統計，2013.06.25，30（3）：438~439
18. 吳瑩, 侯艷, 李康. 適應性無縫設計在臨床試驗中的套用及研究進展, 中國衛生統計，2013.03.25,30(1):140~142
19. 吳瑩, 侯艷, 李康. 三臂非劣效臨床試驗的評價方法, 中國衛生統計, 2013.02.25，30（1）：127~130
20. Handbook of Medical Statistics / edited by Ji-Qian Fang. World Scientific Publishing Co. Pte. Ltd. 26 June 2017.
21. Kai Yang; Ying Wu *. A prognosis-related molecular subtype for early-stage non-small lung cell carcinoma by multi-omics integration analysis, BMC Cancer, 2021, 21(1): 128.
22. Yanpeng Wu; Jianhong Pan; Dong Han; Lixin Li; Yanfei Wu; Rui Liao; Zijie Liu; Dingyun You; Pingyan Chen *; Ying Wu *. Ethnic disparities in stillbirth risk in Yunnan, China: a prospective cohort study, 2010-2018, BMC Public Health, 2021, 21(1): 136.
23. Xiaoyang Jia; Minfei Qiang; Kun Zhang; Qinghui Han; Ying Wu *; Yanxi Chen *. Influence of Timing of Postoperative Weight-Bearing on Implant Failure Rate Among Older Patients With Intertrochanteric Hip Fractures: A Propensity Score Matching Cohort Study. Frontiers in medicine, 2021.Dec, 8: 795595.
24. Juan Chen #; Ying Wu #; Yuelin He; Xiaoqin Feng; Yuqiong Ren; Shiting Liu *. Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children. Frontiers in pediatrics, 2022.Mar, 10: 846411.
25. Lei He #; Yaxuan Pi #; Yi Li #; Ying Wu #; Jingru Jiang; Xiaoming Rong; Jinhua Cai; Zongwei Yue; Jinping Cheng; Honghong Li; Melvin Lee Kiang Chua; Charles B Simone 2nd; Wilbert S Aronow; Simona Lattanzi; Joshua D Palmer; Jan Gaertner; Jon Glass; Pingyan Chen; Yamei Tang*. Efficacy and safety of apatinib in radiation-induced brain injury among head and neck cancer: an open-label, single-arm, phase 2 study. International journal of radiation oncology, biology, physics, 2022.Apr, S0360-3016(22)00268-1.
26. Ying Wu #; Yanpeng Wu; Jie Chen; Pingyan Chen*. A Quantitative Bias Analysis to Assess Constancy Assumption in Non-Inferiority Trials Using Bayesian Hierarchical Models. Statistics in Biopharmaceutical Research, 2022;14(4):473-479.
27. Yuemiao Zhang#, Xupu Ma#, Guanghong Yan#, Ying Wu#, Yanli Chen, Zumi Zhou, Na Wan, Wei Su, Feng-Wei Liu, Mu-Xian Dai, Mei Yang, Chunmei Li, Xuanjing Yu, Liang Zhang, Zhongfang Wang, Tai-Cheng Zhou, Dingyun You, Jia Wei*, Zijie Zhang*, Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial. eClinicalMedicine, 2022;54:101680.
28. Jiangdong Liu, Hang Dong, Mengmeng Li, Ying Wu, Chunlin Zhang, Jinjian Chen, Zhou Yang, Guozhen Lin, De Li Liu, Jun Yang, Projecting the excess mortality due to heatwave and its characteristics under climate change, population and adaptation scenarios, International Journal of Hygiene and Environmental Health, 2023;250:114157.
29. 邢星, 吳瑩*, 陳平雁. 配對設計中缺乏差值標準差情況下的樣本量估計策略. 中國衛生統計, 2021;38(2): 181-182, 187頁.
30. Wu, Y.#, Zeng, F.#, Li, J.#, Jiang, Y., Zhao, S., Knibbs, L. D., Zhang, X., Wang, Y., Zhang, Q., Wang, Q., Hu, Q., Guo, X., Chen, Y., Cao, G., Wang, J., Yang, X., Wang, X., Liu, T.*, & Zhang, B*. Sex-specific relationships between prenatal exposure to metal mixtures and birth weight in a Chinese birth cohort. Ecotoxicology and environmental safety. 2023; 262: 115158. DOI: 10.1016/j.ecoenv.2023.115158
31. Li G, Jankowich MD, Wu L, Lu Y, Shao L, Lu X, Fan Y, Pan CW, Wu Y*, Ke C*. Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes. Chest. 2023; S0012-3692(23)00794-8. doi: 10.1016/j.chest.2023.05.031. Epub ahead of print. PMID: 37356807.
32. Liu S#, Wu Y#, Qi S, Shao H, Feng M, Xing L, Liu H, Gao Y, Zhu Z, Zhang S, Du Y, Lu Y, Yang J, Chen P, Sun T*. Polymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial. Critical care (London, England). 2023;27(1): 232. DOI: 10.1186/s13054-023-04522-6.
33. Chen, J., Chen, R., Feng, Y., Tan, M., Chen, P., Wu, Y*. On variance estimation of target population created by inverse probability weighting. J Biopharm Stat. 2024;34(5):661-679. doi:10.1080/10543406.2023.2244593.
34. Yang, C.#, Zheng, Z.#, Zheng, P., Chen, J., Huang, Q., Chen, Y., Zhou, Y., Chen, P., Li Y*, Wu Y*. Inactivated COVID-19 vaccines in peri-pregnancy period: Evaluation of safety for both pregnant women and neonates. Vaccine. 2023 Nov 30;41(49):7450-7459. doi: 10.1016/j.vaccine.2023.11.011.
35. Chen, J., Li, L., Feng, Y., Chow, S., Tan, M., Pan, J., Chen, P., Wu, Y*. Sequential Adaptive Design Method for Incorporating External Data. Biometrical Journal. 2024. Accepted for publication.
