吳杭，男，博士，現為安徽大學生命科學學院副教授。
基本介紹
- 中文名：吳杭
- 畢業院校：上海交通大學
- 學位/學歷：博士
- 專業方向：生命科學
人物經歷,研究領域,學術論文,
人物經歷
2004年和2007年分別獲安徽大學學士和碩士學位，2012年博士畢業於上海交通大學微生物代謝國家重點實驗室，隨後進入安徽大學進行教學與科研工作，學科類別隸屬生物工程學與微生物學。2016-2018年在美國波士頓大學化學系（Boston University）和麻省理工學院生物工程系（Massachusetts Institute of Technology）進行博士後及訪問研究。
研究領域
基因調控與代謝工程、微生物功能組學、藥物工業生產菌株的定向改造及其產業化探索等。
學術論文
Xu Y, Tan G, Ke M, Li J, Tang Y, Meng S, Niu J, Wang Y, Liu R, Wu H*, Bai L, Zhang L, Zhang B.Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis.J Ind Microbiol Biotechnol. 2018, 45(5):345-355.
Meng S, Wu, H, Wang L, Zhang B, Bai L. Enhancement of antibiotic productions by engineered nitrate utilization in actinomycetes. Appl Microbiol Biotechnol. 2017, 101(13): 5341-5352.
Liu J, Chen Y, Wang W, Ren M, Wu P, Wang Y, Li C, Zhang L, Wu H*, Weaver DT*, Zhang B*. Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. Metab Eng. 2017, 39: 29-37.
Lu C, Wu H, Su X, Bai L. Elimination of indigenous linear plasmids in Streptomyces hygroscopicus var. jinggangensis and Streptomyces sp. FR008 to increase validamycin A and candicidin productivities. Appl Microbiol Biotechnol. 2017, 101(10):4247-4257.
Wu H, Wang Y, Yuan L, Mao Y, Wang W, Zhu L, Wu P, Fu C, Müller R, Weaver DT, Zhang L, Zhang B. Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea. Synthetic Systems Biotechol. 2016, 1(1): 39-46. Inaugural issue.
Wu H, Li W, Xin C, Zhang C, Yuan L, Zhao W, Wang Y, Ren S, Ren M, Huang X, Xu Z, Yuan H, Geng M, Zhang L, Weaver D, Zhang B. In vivo Investigation to the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII in Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 2016, 100(5): 2257-2266.
Qu S, Kang Q, Wu H, Wang L, Bai L. Positive and negative regulation of GlnR in validamycin A biosynthesis by binding to different loci in promoter region. Appl Microbiol Biotechnol. 2015, 99(11): 4771-4783.
Wu H, Mao Y, Chen M, Pan H, Huang X, Ren M, Wu H, Li J, Xu Z, Yuan H, GengM, Weaver D, Zhang L, Zhang B. Capturing the target sequences of BldD in Saccharopolyspora erythraea using a revised SELEX method.Appl Microbiol Biotechnol. 2015, 99(6): 2683-2692.
Zhang P, Wu H, Chen X, Deng Z, Bai L, Pang X. Regulation of the biosynthesis of thiopeptide antibiotic cyclothiazomycin by the transcriptional regulator SHJG8833 in Streptomyces hygroscopicus 5008. Microbiology. 2014, 160 (Pt 7): 1379-1392.
Wu H, Chen M, Mao Y, Li W, Liu J, Huang X, Zhou Y, Ye B, Zhang L, Weaver D, Zhang B. Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea.Microb Cell Fact. 2014, 13: 158.
Wu P, Pan H, Zhang C, Wu H*, Yuan L, Huang X, Zhou Y, Ye B, Weaver D, Zhang L, Zhang B*. SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 2014, 41(7):1159-1167.
Yin X, Xu X, Wu H*, Yuan L, Huang X, Zhang B*. SACE_0012, a TetR family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea. Curr Microbiol. 2013, 67(6):647-651.
Wu H, Qu S, Lu C, Zheng H, Zhou X, Bai L, Deng Z. Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008. BMC Genomics. 2012, 13: 37.
Wei ZH, Wu H, Bai L, Deng Z, Zhong JJ. Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008. Bioprocess Biosyst Eng. 2012, 35(8):1309-1316.
Zhou X, Wu H, Li Z, Zhou X, Bai L, Deng Z. Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus 5008. Metab Eng. 2011, 13, 768-776.
