基本介紹
- 中文名：俞飈
- 國籍：中國
- 民族：漢族
- 出生地：浙江
- 出生日期：1967.11
獲得榮譽,研究方向,論文目錄,
獲得榮譽
曾獲中國化學會青年化學獎(1998年); 中科院傑出青年(2000年); 國家傑出青年基金(1999年); 上海市科技啟明星和學科帶頭人基金(1999,2002,2006年); 首批新世紀百千萬人才工程國家級人選(2004年); 上海市自然科學二等獎(2006年)等: 國家自然科學二等獎（2010）。
研究方向
具有重要生理活性的複雜寡糖、糖綴合物及其它天然產物，如：動物糖胺聚糖(如肝素)和特徵腫瘤抗原、微生物抗生素、植物和海洋糖苷(如皂甙和黃酮甙)等的全合成、合成方法學和化學生物學.
其它研究內容還涉及：中藥；天然產物的分離鑑定；糖基轉移酶和糖苷水解酶抑制劑；兼親分子的超分子化學等.
論文目錄
（部分）
1. Total synthesis of Lobatoside E, a potent antitumor cyclic triterpene saponin. C. Zhu, P. Tang, B. Yu, J. Am. Chem. Soc. 2008, 130, 5872-5873.
2. Gold(I) catalyzed glycosidation of 1,2-anhydrosugars. Y. Li, P. Tang, Y. Chen, B. Yu, J. Org. Chem. 2008, 73, 4323-4325.
3. Synthesis of Betavulgaroside III, a representative triterpene seco-glycoside. S. Zhu, Y. Li, B. Yu, J. Org. Chem. 2008, 73, 4978-4985.
4. Isoflavone glycosides: synthesis and evaluation as α-glucosidase inhibitor. G. Wei, B. Yu, Eur. J. Org. Chem. 2008, 3156-3163.
5. Effective synthesis of nucleosides with glycosyl trifluoroacetimidates as donors. J. Liao, J. Sun, B. Yu, Tetrahedron Lett. 2008, 49, in press.
6. An efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph3PAuOTf. Y. Li, Y. Yang, B. Yu, Tetrahedron Lett. 2008, 49, 3604-3608.
7. Effective protection of the N-sulfate of glucosamine derivatives with the 2,2,2-trichloroethyl group. J. Chen, B. Yu, Tetrahedron Lett. 2008, 49, 1682-1685.
8. A proline-catalyzed aldol approach to the synthesis of 1-N-iminosugars of the D-glucuronic acid type. C. Chen, B. Yu, Tetrahedron Lett. 2008, 49, 672-674.
9. Dioseptemlosides A-H: cholestane and spirostane glycosides from the rhizomes of Dioscorea septemloba. X.-T. Liu, Z.-Z. Wang, W. Xiao, H.-W. Zhao, J. Hu, B. Yu, Phytochemistry 2008, 69, 1411-1418.
10. Synthesis of a tetrasaccharide substrate of heparanase. J. Chen, Y. Zhou, C. Chen, W. Xu, B. Yu, Carbohydr. Res. 2008, in press.
11. Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. M. Zha, Q. Guo, Y. Zhang, B. Yu, Y. Ou, C. Zhong, J. Ding, J. Mol. Biol. 2008, 379, 568-578.
12. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells. R. C. Y. Ong, J. Lei, R. K. Y. Lee, J. Y. N. Cheung, K. P. Fung, C. Lin, H. P. Ho, B. Yu, M. Li, S. K. Kong, Cancer Lett. 2008, 261, 158-164.
13. Total synthesis of Candicanoside A, a potent antitumor saponin bearing a rearranged steroid side chain. P. Tang, B. Yu, Angew. Chem. Int. Ed. 2007, 46, 2527-2530.
14. Carbohydrate chemistry in the total synthesis of saponins. B. Yu, Y. Zhang, P. Tang, Eur. J. Org. Chem. 2007, 5145-5161. (Review)
15. Synthesis of steroidal saponins bearing an aromatic E ring. Z. Wang, M. Li, X. Liu, B. Yu, Tetrahedron Lett. 2007, 48, 7323-7326.
16. N-Dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions. Y. Yang, B. Yu, Tetrahedron Lett. 2007, 48, 7049-7052.
17. The N-dimethylphosphoryl-protected glucosamine trichloroacetimidate as an effective glycosylation donor. Y. Yang, B. Yu, Tetrahedron Lett. 2007, 48, 4557-4560.
18. The cytotoxicity of saponins correlates with their cellular internalization. Y. Wang, Y. Zhang, B. Yu, ChemMedChem 2007, 2(3), 888-291. (Cover Picture)
19. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins. Y. Wang, Y. Zhang, Z. Zhu, S. Zhu, Y. Li, M. Li, B. Yu, Bioorg. Med. Chem. 2007, 15, 2528-2532.
20. Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. P. Tang, F. Mamdani, X. Hu, J. O. Liu, B. Yu, Bioorg. Med. Chem. Lett. 2007, 17, 1003-7.
21. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. W. Peng, P. Tang, X. Hu, J. O. Liu, B. Yu, Bioorg. Med. Chem. Lett. 2007, 17, 5506-5509.
22. Antibacterial diterpenoids from Sagittaria pygmaea. X. -T. Liu, Y. Shi, B. Yu, I. D. Williams, H. H. -Y. Sung, Q. Zhang, J. -Y. Liang, N. Y. Ip, Z. -D. Min, Planta Med. 2007, 73, 86-90.
23. Synthesis, cytotoxicity, and hemolytic activity of 6’-O-substituted dioscin derivatives. W. Li, Z. Qiu, Y. Wang, Y. Zhang, M. Li, J. Yu, L. Zhang, Z. Zhu, B. Yu, Carbohydr. Res. 2007, 342, 2705-2715.
24. Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues. S. Zhu, Y. Zhang, M. Li, J. Yu, L. Zhang, Y. Li, B. Yu, Bioorg. Med. Chem. Lett. 2006, 16, 5629-5632.
25. Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue. M. Li, B. Yu, Org. Lett. 2006, 8(13), 2679-2682.
