研究方向
內分泌對心血管系統影響的基礎與臨床研究、糖尿病與甲狀腺疾病的臨床研究
教育經歷
The University of Kiel, Germany (德國基爾大學) 醫學系藥理學研究所心血管藥理學專業(獲得德國高血壓研究所獎學金全額資助),2003年10月獲博士學位(論文評審及答辯優秀,magna cum laude);
上海中醫藥大學中西醫結合內科學專業,1997年7月獲碩士學位;
上海第二醫科大學六年制本科醫療系醫學專業,1987年7月獲學士學位
工作經歷
2009/2–加盟上海交通大學醫學院附屬第九人民醫院內科,現任主任醫師,研究生導師;
2007/3–2009/6 夏威夷大學合作研究部,SNRP2項目研究員;
2007/3–2009/2 夏威夷大學醫學院細胞與分子生物系,助理研究員
2005/8–2007/2 美國加利福尼亞大學San Diego分校醫學院內科,博士後Scientist
2003/11–2005/7 德國馬普實驗醫學研究所,全職BATIIa博士後Staff Scientist
2003/1–2003/10 德國基爾大學附屬醫院心內科, Scientist
1987/8–2001/1 上海市岳陽醫院心內科醫師及西醫內科,歷任住院醫師、住院總醫師、主治醫師、主任助理、副主任醫師、碩導
主要論文
SCI全文收錄:
1.Yang LZ(仰禮真), Zhu YC. Urocortin2 prolongs action potential duration and modulates potassium currents in guinea pig myocytes and HEK293 cells. European Journal of Pharmacology 2015:758;97-106. (通訊作者)
2.Walther S, Pluteanu F, Renz S, Nikonova Y, Maxwell JT, Yang LZ(仰禮真), Schmidt K, Edwards JN, Wakula P, Groschner K, Maier LS, Spiess J, Blatter LA, Pieske B, Kockskämper J. Urocortin2 stimulates nitric oxide production in ventricular myocytes via Akt-and PKA-mediated phosphorylation of eNOS at serine 1177. Am J Physiol Heart Circ Physiol. 2014;307(5):H689-700. 3. Yang LZ(仰禮真), Kockskämper J, Khan S, Suarez J, Walther S, Doleschal B, Unterer G, Khafaga M, Mächler H, Heinzel FR, Dillmann WH, Pieske B, Spiess J. cAMP- and Ca2+/calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin2 in mouse ventricular myocytes. British Journal of Pharmacology 2011:162(2);544-556.
4. Yang LZ(仰禮真),Tovote P, Rayner M, Kockskämper J, Pieske B, Spiess J. CRF and its analogs, link the brain and the heart. European Journal of Pharmacology 2010:632;1-6. (兼共同通訊作者).
5. Yang LZ(仰禮真), Kockskämper J, Heinzel FR, Hauber M, Walther S, Spiess J, Pieske B. Urocortin2 enhances contractility in rabbit ventricular myocytes via CRF2 receptor-mediated stimulation of protein kinase A. Cardiovascular Research 2006:69;402-411.
6. Lu YL, Jiang BR, Xia FZ, Zhai HL, Chen Y, Yu J, Zhao LJ, Wang NJ, Qiao J, Yang LZ(仰禮真). Changes of pituitary and penile structure in male adult rats following castration and high-fat diet. Journal of Endocrinological Investigation 2011:34(2);111-116.
7. Li YX, Jiang B, Li Y, Xia F, Yu J, Yang LZ(仰禮真), Shi C, Lu YL. Horm Metab Res. Mitochondrial Apoptotic Pathways: A mechanism for low androgen-induced vascular endothelial injury in male rats. Hormone and Metabolic Research 2011:43(6);374-379.
8. Lu YL, Ye TT, Chen Y, Yu J, Wang N, Jiang B, Qiao J, Yang LZ(仰禮真). Rosiglitazone protects diabetic rats from liver destruction. Journal of Endocrinological Investigation 2011:34;775-780. (兼共同通訊作者). 9. Lu YL, Ye L, Wu H, Xia FZ, Yu J, Yang LZ(仰禮真)*. The up-regulated expression of both phospholipase A2 and cyclooxygenase-2 is involved in renal injury in streptozotocin- induced diabetic rats. Acta Endocrinologica (Buc) 2013:9(1);23-32. (兼通訊作者) 參加與相關的國際會議:
1.Yang LZ(仰禮真),Kockskämper J, Walther S, Heinzel FR, Hauber M, Walther S, Suarez J, Dillmann WH, Zhu YC, Pieske B, Spiess J. Urocortin II increases contractility but may produce arrhythmogenic effects (at high concentration) in myocytes. International Conference on Pharmacology and Drug Development; Singapore.Dec.9-11,2013
2.Kockskämper J, Yang LZ(仰禮真), Walther S, Spiess J, Pieske B. Urocortin II verbessert die kontraktile Funktion isolierter Ventrikelmyozyten durch Aktivierung des cAMP-PKA- und des PI3K-Akt- eNOS-Signalwegs. Eur. Surg. 2007;39(S213): Cardiovascular Research Days 2007;Weissensee, Austria. Jan. 18-20,2007 [Oral Communication]
3.Kockskämper J, Yang LZ(仰禮真), Walther S, Spiess J, Pieske B. Urocortin II-induzierte eNOS-Stimulierung in Kardiomyozyten: Konvergenz des PI3K/Akt- und des cAMP-PKA- Signalweges. Clin Res Cardiol.96(S1): P476.2007- Frühjahrstagung der DGK;Mannheim,Germany.April 12-14,2007
4.Yang LZ(仰禮真),Kockskämper J, Suarez J, Hauber M, Dillmann DH , Pieske B, Spiess J. Urocortin II (UcnII) Increases Contractility of Mouse Ventricular Myocytes via Corticotropin-Releasing Factor Type-2 Receptor(CRF2)-Mediated Pathways.15th World Congress of Pharmacology (IUPHAR 2006) Beijing, China, July 20-27,2006
5.Kockskämper J; Yang LZ(仰禮真),Walther S; Spiess J; Pieske B. Beteiligung von NO und cGMP am positiv inotropen und positiv lusitropen Effekt von Urocortin II in Kardiomyozyten. Clin Res Cardiol.2006; 95(S5):P104--Frühjahrstagung der DGK; Mannheim, Germany. April 20-22,2006
6.Kockskämper J, Yang LZ(仰禮真),Walther S, Spiess J, Pieske B. Urocortin II increases contractility in rabbit ventricular myocytes via the PI3K-Akt pathway and NO-cGMP signalling. Acta Physiologica2006; 186: -Joint Meeting of the German Society of Physiology and the Federation of European Physiological Societies (FEPS); Munich, Germany. March 26-29, 2006 [Oral Communication]
7.Yang LZ(仰禮真),Kockskämper J, Hauber M, Pieske B, Spiess. Urocortin II produces a positive inotropic effect on rabbit ventricular myocytes. VII Svenska Kardiovaskulära Vårmötet/XX Nordic Congress of Cardiology.April27-29,2005, Malmö, Sweden. Published in the Scandivian Cardiovascular Journal; 39 (suppl53): 13-14. 2005
8.Kockskämper J, Yang LZ(仰禮真),Hauber M, Spiess J, Pieske B.Urocortin II erhöht Kontraktilität und Ca-Transienten in Kaninchen-Ventrikelmyozyten über eine CRF2–Rezeptor -vermittelte Stimulierung von Protein kinase A.Z.Kardiol. P1296. Meeting: DGK Mannheim (German Association of Cardiology). Mannheim, Germany. March31–April 2,2005
9.Yang LZ(仰禮真),Kockskämper J, Pieske B, Spiess J. Urocortin II increases contractility in rabbit ventricular myocytes via CRF2 receptors and PKA. The first meeting for working group on Acute Cardiac Care, Rome, Italy.Oct.17-20,2004 "