魏斌，男，博士，副研究員，碩士生導師，主持國家重點研發計畫青年科學家項目子課題、國家自然科學基金青年基金等科研項目9項，參與國家重點研發計畫等其他橫縱向項目6項。在天然藥物與微生物組等領域已發表SCI論文100餘篇(ESI高被引論文4篇)，其中以第一/通訊作者在Microbiome, Biotechnol. Adv., J. Med Chem., Bioresour. Technol., Environ. Microbiol., J. Nat. Prod.等國際權威期刊發表學術論文40餘篇，已被Nature等高水平期刊引用2000餘次, h-index為26。以第一發明人申請/授權發明專利或軟體著作10餘項。擔任iMeta, Eur. J. Med. Chem.等20餘種國際知名學術期刊審稿人和英國科學創新基金(UKRI)等項目通訊評審專家。
基本介紹
人物經歷,個人榮譽,學習經歷,工作經歷,研究方向,學術任職,科研項目,科研成果,獲獎情況,
人物經歷
博士，副研究員，碩士生導師，主持國家重點研發計畫青年科學家項目子課題、國家自然科學基金青年基金等科研項目9項，參與國家重點研發計畫等其他橫縱向項目6項。在天然藥物與微生物組等領域已發表SCI論文100餘篇(ESI高被引論文4篇)，其中以第一/通訊作者在Microbiome, Biotechnol. Adv., J. Med Chem., Bioresour. Technol., Environ. Microbiol., J. Nat. Prod.等國際權威期刊發表學術論文40餘篇，已被Nature等高水平期刊引用2000餘次, h-index為26。以第一發明人申請/授權發明專利或軟體著作10餘項。擔任iMeta, Eur. J. Med. Chem.等20餘種國際知名學術期刊審稿人和英國科學創新基金(UKRI)等項目通訊評審專家。
個人榮譽
2022年度Front. Microbial. 期刊優秀審稿編輯
2023年入選浙江工業大學青年英才B類人才項目
2023年入選浙江工業大學高層次人才(C類優先資助)培育計畫
學習經歷
2007.09-2011.06 武漢大學藥學院 理學學士學位
2011.09-2013.06 武漢大學藥學院 製藥工程碩士學位
2013.09-2018.08 澳門大學中華醫藥研究院 生物醫藥博士學位
工作經歷
2018.11-至 今 浙江工業大學藥學院/綠色製藥協同創新中心
研究方向
1. 海洋微生物天然產物化學
2. 微生物天然產物和代謝酶發現新策略
3. 基於人工智慧技術的抗菌肽高效發現
4. 天然產物與腸道菌相互作用研究
學術任職
1. 中國藥學會海洋藥物專業委員會青年委員
2. 中國藥理學會海洋藥物藥理專業委員會青年委員
3. Chinese Medicine, Engineering Microbiology, Phytochemical Analysis等國際知名期刊青年編委
4. Front. Microbial. 期刊審稿編輯
5. Mar. Drugs, J. Mar. Sci. Eng.等期刊客座編輯
科研項目
1. 國家自然科學基金國際(地區)合作項目《中埃紅樹林微生物菌群及抗菌次級代謝產物多樣性研究》200萬元 參與(排名第二)
2. 廣西北部灣海洋資源環境與可持續發展重點實驗室開放基金重點項目《北部灣紅樹林微生物次級代謝潛力研究》 3萬元 主持
3. 國家重點研發計畫青年科學家項目《基於原位富集培養和PSMPA策略的深海冷泉微生物藥物先導化合物挖掘技術》子課題 60萬元 主持
4. 浙江省屬高校基本科研業務費項目《海洋微生物藥物先導物的智慧型發現》10萬元 主持
5. 國家自然科學基金面上基金項目《基於PSMPA技術的深海微生物抗細菌耐藥性次級代謝產物多樣性的研究》 56萬元 參與(排名第二)
6. 國家自然科學基金青年基金項目《基於宏基因組技術的腸道菌多糖裂解酶介導海藻多糖治療代謝綜合徵的研究》24萬元 主持
7. 浙江省基礎公益研究計畫項目《腸道菌介導的黃嘌呤代謝對高脂飲食誘導的肥胖模型的影響》8萬元 主持
8. 浙江省博士後擇優資助項目《海帶多糖與腸道菌多糖代謝酶的相互作用研究》5萬元 主持
9. 自然資源部第二海洋研究所博士後項目《腸道菌多糖裂解酶介導海帶多糖治療肥胖的研究》7萬元 主持
10. 企業橫向項目《微生物轉化在工業廢液處理中的套用》10萬元 主持
11. 企業橫向項目《貴州篤山石斛口服液產品預研和質量研究》10萬元 主持
科研成果
代表性學術論文:
42. Qing-Hong Meng, Yu-Tian Guan, Jing-Hai Wang, Xing-Yan Wang, Xiang-Mei Ren, Hai-Yan Sui, Bin Wei, Xiao-Ying Bian. Genome mining of Chromobacterium genus reveals a class of nonribosomal lipopeptides with potent antifungal activity. Journal of Agricultural and Food Chemistry (2025). (中科院一區, 工大TOP, IF=6.2)Full text.pdf Highlighted by Biosyn | 天然產物[Link]
41. Huai-Ying Sun, Ji-Xiang Xin, Gen Li, Zhen-Yi Zhou, Xin Li, Hong Wang, Qun-Jian Yin, Bin Wei. Complete genome sequence of Lysinibacillus sp. WB86, a potential antimicrobial lanthipeptides producer. Marine Genomics (2025), 82: 101204. Full text.pdf
40. Gang-Ao Hu, Huai-Ying Sun, Qun-Jian Yin, He Wang, Shi-Yi Liu, Bin-Gui Wang, Hong Wang, Xin Li, Bin Wei. Exploring the biosynthetic potential of microorganisms from the South China Sea cold seep using culture-dependent and culture-independent approaches. Marine Drugs (2025), 23: 313. Full text.pdf
39. Bing-Cheng Dong, Fen Liu, Gang-Ao Hu, Wen-Chao Yu, Zi-Yang Li, Yu-Tian Guan, Wen-Wen Zhang, Hong Wang, Bin Wei. Metabologenomics analysis reveals antibiotic crypticity of Kutzneria viridogrisea DSM 43850. Journal of Applied Microbiology (2025), 136(5): lxaf114. Full text.pdf
38. Yi Hua, Gang-Ao Hu, Ti-Ti Ying, Jiang-Wei Pan, Zhen-Yi Zhou, Cui-Xian Zhang, Hong Wang, Bin Wei. The pathogenic fungal genus Corynespora: a prolific source of bioactive secondary metabolites. Journal of Natural Products (2025), 68(3): 2183-2197. (中科院二區, 藥學TOP) Full text.pdf
37. Cai-Ling Yang, Pan-Pan Wang, Zhen-Yi Zhou, Xiao-Wen Wu, Yi Hua, Jian-Wei Chen, Hong Wang, Bin Wei. Discovery of naturally inspired antimicrobial peptides using deep learning. Bioorganic Chemistry (2025), 160: 108444. (中科院二區)Full text.pdf Highlighted by CBG資訊[Link]
36. Buddha Bahadur Basnet, Zhen-Yi Zhou, Bin Wei, Hong Wang. Advances in AI-based strategies and tools to facilitate natural product and drug development. Critical Reviews in Biotechnology (2025). Full text.pdf (中科院二區, IF=8.2)
35. Ti-Ti Ying, Hao-Qiang Hu, Xiao-Wen Wu, Xu-Liang Xu, Jian Lv, Shu-Ning Zhang, Hong Wang, Wei Hou, Bin Wei, Guo-Wu Rao. Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors. European Journal of Medicinal Chemistry (2025), 290: 117571. Full text.pdf (工大TOP100, IF=6.0) Highlighted by CBG資訊[Link]
34. Bin Wei, Ti-Ti Ying, Hua-Wei Lv, Zhen-Yi Zhou, Hai Cai, Gang-Ao Hu, Hui-Min Liang, Wen-Chao Yu, Yan-Lei Yu, Ai-Li Fan, Kui Hong, Xing-Nuo Li, Hong Wang. Global analysis of fungal biosynthetic gene clusters reveals the diversification of diketopiperazine biosynthesis. Bioresource Technology (2025), 422: 132218. Full text.pdf (中科院一區, 工大TOP100, IF=9.7) Highlighted by 遇見生物合成[Link]
33. Shu-Yu Yang(本科生), Ti-Ti Ying, Tian-Hui Zhou (本科生), Yu-Tian Guan, Xu-Liang Xu, Hong Wang, Bin Wei. The Myxobacterial Genus Archangium: A Prolific and Underexploited Source of Bioactive Secondary Metabolites. Journal of Medicinal Chemistry (2025), 68(3): 2183-2197. Full text.pdf (中科院一區, 工大TOP100, IF=6.8) Highlighted by X-MOL[Link]; 浙工大藥學院[Link]
32. Wei-Bing Chen, Gang-Ao Hu, Bing-Cheng Dong, Huai-Ying Sun, Dong-Ze Lu, Meng-Ying Ru, Yan-Lei Yu, Hong Wang, Bin Wei. Insights into the modulatory effects of host-gut microbial xanthine co-metabolism on high-fat diet-fed mice. Biochemical Pharmacology (2024), 230(1): 116596. Full text.pdf
31. Gang-Ao Hu, Yue Song, Shi-Yi Liu, Wen-Chao Yu, Yan-Lei Yu, Hong Wang, Bin Wei. Exploring the diversity and specificity of secondary biosynthetic potential in Rhodococcus. Marine Drugs (2024), 22: 409. Full text.pdf
30. Si-Jia Wang, Zi-Xi Fu, Wei-Bing Chen, Si-Tong Wu, Song-Ze Ke, Jian-Feng Tu, Bin Wei. Saccharina japonica polysaccharides suppress high-fat diet-induced obesity and modulate gut microbiota composition and function. Chemistry & Biodiversity (2024), 21(8): e20241088. Full text.pdf
29. Man-Jing Ma, Wen-Chao Yu, Huai-Ying Sun, Bing-Cheng Dong, Gang-Ao Hu, Zhen-Yi Zhou, Yi Hua, Buddha Bahadur Basnet, Hong Wang, Bin Wei. Genus-specific secondary metabolome in Allokutzneria and Kibdelosporangium. Synthetic and Systems Biotechnology (2024), 9(3): 381-390. Full text.pdf Highlighted by 合成和系統生物技術[Link]
28. Bin Wei, Xian Luo, Zhen-Yi Zhou, Gang-Ao Hu, Lei Li, Hou-Wen Lin, Hong Wang. Discovering the secondary metabolic potential of Saccharothrix. Biotechnology Advances (2024), 70: 108295. Full text.pdf (中科院一區, IF=16.0) Highlighted by 遇見生物合成[Link]; 浙工大科研院[Link]
27. Qun-Jian Yin, Ti-Ti Ying, Zhen-Yi Zhou, Gang-Ao Hu, Cai-Ling Yang, Yi Hua, Hong Wang, Bin Wei. Species-specificity of the secondary biosynthetic potential in Bacillus. Frontiers in Microbiology (2023), 14: 1271418. Full text.pdf
26. Bin Wei, Gang-Ao Hu, Zhen-Yi Zhou, Wen-Chao Yu, Ao-Qi Du, Cai-Ling Yang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Qi-Hao Wu, Qi Xuan, Xue-Wei Xu, Hong Wang. Global analysis of the biosynthetic chemical space of marine prokaryotes. Microbiome (2023), 11: 144. Full text.pdf (中科院一區, IF=16.837) Highlighted by 遇見生物合成[Link]; 浙工大科研院[Link]
25. Bin Wei, Ao-Qi Du, Ti-Ti Ying (本科生), Gang-Ao Hu, Zhen-Yi Zhou, Wen-Chao Yu, Jing He, Yan-Lei Yu, Hong Wang, Xue-Wei Xu. Secondary metabolic potential of Kutzneria. Journal of Natural Products (2023), 86(4): 1120-1127. Full text.pdf (藥學TOP, IF=4.803) Highlighted by 遇見生物合成[Link]; 相聚植化[Link]
24. Ying Song, Dong-Ze Lu, Hong-Gang Wang, Zhen-Yi Zhou, Xian Luo, Man-Jing Ma, Song-Ze Ke, Hong Wang, Yan-Lei Yu, Bin Wei. Metagenomic insights into the anti-obesity effect of a polysaccharide from Saccharina japonica. Foods (2023), 12(3): 665. Full text.pdf
23. Ao-Qi Du, Ti-Ti Ying (本科生), Zhen-Yi Zhou, Wen-Chao Yu, Gang-Ao Hu, Xian Luo, Man-Jing Ma, Yan-Lei Yu, Hong Wang, Bin Wei. Non-ribosomal peptide biosynthetic potential of the nematode symbiont Photorhabdus. Environmental Microbiology Reports (2022), 14: 917-925. Full text.pdf
22. Bin Wei, Bo Zhang, Ao-Qi Du, Zhen-Yi Zhou, Dong-Ze Lu, Zhong-Hui Zhu (本科生), Song-Ze Ke, Si-Jia Wang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin, Hong Wang. Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria. Carbohydrate Polymers (2022), 290: 119411. Full text.pdf (中科院一區, IF=10.723) Highlighted by 熱心腸日報[Link]
21. Song-Ze Ke, Bo Zhang, Yan-Lei Yu, Si-Jia Wang, Wei-Hua Jin, Jian Wu, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei, Hong Wang. Structural characterization of a sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice. Journal of Oceanology and Limnology (2022), 41: 300-313. Full text.pdf
20. Bin Wei, Ao-Qi Du, Zhen-Yi Zhou, Cong Lai (本科生), Wen-Chao Yu, Jin-Biao Yu, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Xue-Wei Xu, Hong Wang. An atlas of bacterial secondary metabolite biosynthesis gene clusters. Environmental Microbiology (2021), 23(11): 6981-6992. Full text.pdf (工大TOP100, IF=5.476) Highlighted by 遇見生物合成[Link]; 浙工大科研院[Link]
19. Bin Wei, Si-Jia Wang, Ya-Kun Wang, Song-Ze Ke, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Jia-Dong Sun, Susanne M. Henning, Jian Wang, Hong Wang. Gut microbiota mediated-xanthine metabolism is associated with resistance to high-fat diet induced obesity. Journal of Nutritional Biochemistry (2021), 88: 108533. Full text.pdf
18. Qi-Wu Zhong, Tao-Shun Zhou, Wei-Hui Qiu, Ya-Kun Wang, Qiao-Li Xu, Song-Ze Ke, Si-Jia Wang, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei, Hong Wang. Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida. Food Chemistry (2021), 341: 128148. Full text.pdf (中科院一區, IF=9.231) (ESI高被引論文)
17. Song-Ze Ke, Yan-Lei Yu, Qiao-Li Xu, Bo Zhang, Si-Jia Wang, Wei-Hua Jin, Bin Wei, Hong Wang. Composition-activity relationships of polysaccharides from Saccharina japonica in regulating gut microbiota in short-term high-fat diet-fed mice. Journal of Agricultural and Food Chemistry (2021), 69(37): 11121-11130. Full text.pdf (中科院一區, IF=5.895)
16. Bin Wei, Ya-Kun Wang, Shou-Kui Xiang, Yan Jiang, Rong Chen, Nan Hu. Alterations of gut microbiome in type 2 diabetes mellitus patients undergone cholecystectomy. American Journal of Physiology-Endocrinology and Metabolism (2021), 320(1): E113-E121. Full text.pdf
15. Bin Wei, Qiao-Li Xu, Bo Zhang, Tao-Shun Zhou, Song-Ze Ke, Si-Jia Wang, Bin Wu, Xue-Wei Xu, Wang Hong. Comparative study of Sargassum fusiforme polysaccharides in regulating cecal and fecal microbiota of high-fat diet-fed mice. Marine Drugs (2021), 19(7): 364. Full text.pdf
14. Bin Wei, Ya-Kun Wang, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu, Hong Wang. Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis. Journal of Microbiology (2021), 59(10): 931-940. Full text.pdf
13. Tao-Shun Zhou, Lu-Lu He, Jing He (本科生), Zhi-Kun Yang, Zhen-Yi Zhou, Ao-Qi Du, Jin-Biao Yu, Ya-Sheng Li, Si-Jia Wang, Bin Wei, Zi-Ning Cui, Hong Wang. Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors. Bioorganic Chemistry (2021), 116: 105306. Full text.pdf
12. Ya-Sheng Li, Min He, Tao-Shun Zhou, Qin Wang, Lu-Lu He, Si-Jia Wang, Bei Hu, Bin Wei, Hong Wang, Zi-Ning Cui. 2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors. European Journal of Medicinal Chemistry (2021), 216: 113322. Full text.pdf (中科院一區, IF=7.088)
11. Xing-Nuo Li, Lu-Xia Hua, Tao-Shun Zhou, Ke-Bo Wang, Yuan-Yuan Wu, Mahmoud Emam, Xiao-Ze Bao, Jun Chen, Bin Wei. Cinnamic acid derivatives: inhibitory activity against Escherichia coli β-glucuronidase and structure-activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35.1: 1372-1378. Full text.pdf
10. Bin Wei, Qi-Wu Zhong, Song-Ze Ke, Tao-Shun Zhou, Qiao-Li Xu, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin, Hong Wang. Sargassum fusiforme polysaccharides prevent high-fat diet-induced early fasting hypoglycemia and regulate gut microbiota composition. Marine Drugs (2020), 18(9): 444. Full text.pdf
9. Bin Wei, Ya-Kun Wang, Wen-Hui Qiu, Si-Jia Wang, Yue-Hong Wu, Xue-Wei Xu, Hong Wang. Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bonds. Applied Microbiology and Biotechnology (2020), 104(5): 1883-1890. Full text.pdf
8. Xue Yang, Zhong-Hui Zhu (本科生), Xia Ji, Zhao-Ming Liu, Hua Zhang, Bin Wei. Complete genome sequence of Micromonospora craniellae LHW63014, a potential metal ion-chelating agent producer. Marine Genomics (2020), 57: 100830. Full text.pdf
7. Jian-Hua Yin, Wei Ren, Bin Wei, Hui-Min Huang, Ming-Xing Li, Xiao-Xiao Wu, An-Qi Wang et al. Characterization of chemical composition and prebiotic effect of a dietary medicinal plant Penthorum chinense Pursh. Food Chemistry (2020), 319: 126568. Full text.pdf (中科院一區, IF=9.231)
6. Song-Ze Ke, Bin Wei, Tao-Shun Zhou, Wen-Hui Qiu, Si-Jia Wang, Jun Chen, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin, Hong Wang. Structural characterization and α-glucosidase inhibitory and antioxidant activities of fucoidans extracted from Saccharina japonica. Chemistry & Biodiversity (2020), 17.7: e2000233. Full text.pdf
5. Tao-Shun Zhou, Bin Wei, Min He, Ya-Sheng Li, Ya-Kun Wang, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Zi-Ning Cui, Hong Wang. Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35(1): 1736-1742. Full text.pdf
4. Qi-Wu Zhong, Bin Wei, Si-Jia Wang, Song-Ze Ke, Jian-Wei Chen, Hua-Wei Zhang, and Hong Wang. The antioxidant activity of polysaccharides derived from marine organisms: an overview. Marine Drugs (2019), 17(12): 674. Full text.pdf (ESI高被引論文)
3. Bin Wei, Wei Yang, Zhi-Xiang Yan, Qing-Wen Zhang, Ru Yan. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies. Journal of Functional Foods (2018), 48: 210-219. Full text.pdf
2. Bin Wei, Pan-Pan Wang, Zhi-Xiang Yan, Ru Yan. Characteristics and molecular determinants of a highly selective and efficient glycyrrhizin-hydrolyzing β-glucuronidase from Staphylococcus pasteuri 3I10. Applied Microbiology and Biotechnology (2018), 102(21): 9193-9205. Full text.pdf
1. Wei Yang, Bin Wei, Ru Yan. Amoxapine demonstrates incomplete inhibition of β-glucuronidase activity from human gut microbiota. SLAS Discovery: Advancing Life Sciences R&D (2018), 23(1): 76-83. Full text.pdf
參與發表的代表性學術論文:
2. Jian-Wei Chen, Wei Wang, Xu-Bin Hu, Yu-Jie Yue, Xing-Yue Lu, Chen-Jie Wang, Bin Wei, Hua-Wei Zhang, Hong Wang. Medium-sized peptides from microbial sources with potential for antibacterial drug development. Natural Product Reports (2024). [Full text]
1. Wang-Hui Jing, Si-Jing Dong, Xia-Lin Luo, Jing-Jing Liu, Bin Wei, Wei Du, Lin Yang, Hua Luo, Yi-Tao Wang, Si-Cen Wang, Hai-Tao Lu. Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research (2021), 164: 105358. [Full text] (中科院一區, IF=10.334) (ESI高被引論文)
代表性發明專利/軟體著作:
3. 一種環烯醚萜苷類化合物在製備β-葡萄糖醛酸苷酶抑制劑中的套用, 魏斌等, 中國發明專利, ZL202010405502.8
2. 基於擴增子序列預測細菌次級代謝潛力的PSMPA軟體, 魏斌等, 中國軟體著作, 2022SR0269247
1. 擴增子與宏基因組組裝基因組關聯分析軟體16S-MAG-linker, 魏斌等, 中國軟體著作, 2024SR0105676
獲獎情況
1. 2020年獲浙江省網際網路+創新創業大賽金獎1項，指導教師排名第四
2. 2021年獲浙江省海洋知識創新競賽一等獎1項，指導教師排名第二
3. 2022年度綠色製藥協同創新中心優秀教師
4. 2023年指導本科生獲第九屆浙江工業大學“健行杯”本科生學術論壇三等獎1項，指導教師排名第一
5. 2023年被Frontiers in Microbiology評為"2022 Outstanding Review Editor"
6. 2023年指導研究生在第十四屆全國微生物資源學術研討會上獲得“優秀牆報獎”，指導教師排名第一
7. 2023年指導研究生獲國家獎學金
8. 2023年獲第十六屆海洋藥物學術年會青年科學家論壇優秀報告獎
9. 2024年獲浙江工業大學2023屆本科生畢業設計優秀指導教師
10. 2024年獲2023年浙江省專業學位研究生優秀實踐成果指導教師
