金漢永，博士，延邊大學藥學院副教授、博士生導師，吉林省高層次人才D類人才，延邊大學“圖們江學者支持計畫-青年圖們江學者A類”，曾任韓國中央大學生命科學系助理教授、博士生導師。
長期致力於生物醫學交叉領域的科研工作，利用分子醫學和分子細胞生物學的方法尋找遺傳性、腫瘤等疾病的致病誘發因子並闡明其作用及致病機理。
基本介紹
人物經歷,教育經歷,工作經歷,榮譽獎項,科學研究,研究領域,科研項目,論文專著,
人物經歷
教育經歷
2010.08-2015.08 韓國車醫學大學 藥學專業 博士研究生 導師：Jeehyeon Bae&You-Hee Cho
2008.09-2010.08 韓國圓光大學 醫學專業 碩士研究生 導師：Hyun Park
2004.09-2008.06 延邊大學 藥學專業 本科
工作經歷
2022.01-至今 延邊大學 藥學院 副教授 （博士生導師）
2021.09-2021.12 延邊大學 藥學院 講師 （博士生導師）
2018.09-2021.08 韓國中央大學 生命科學系 助理教授 （博士生導師）
2018.03-2018.08 韓國中央大學 藥學院 講師
2015.09-2018.02 韓國中央大學 藥學院 博士後
榮譽獎項
2021年， 延邊大學 “圖們江學者支持計畫-青年圖們江學者A類”
2023年， 吉林省高層次人才D類人才
科學研究
研究領域
分子細胞生物學、腫瘤學、藥理學
科研項目
(1) 國家自然科學基金委員會, 地區科學基金項目, 82260588, 鑑定FOXL2/p53介導的抑制卵巢顆粒細胞瘤 轉移的調控網路, 2023-01-01 至 2026-12-31, 33萬元, 在研, 主持
(2) 吉林省科技廳, 吉林省自然科學基金, 482022066, AP5M1在大腸癌的生物學功能及調控機制研究, 2022-07 至 2025-06, 10萬元, 在研, 主持
(3) the National Research Foundation of Korea(NRF), "Fundamental research program" （相當於國內面向項目）, 2019R1F1A1059528, Identification of pathophysiological mechanisms of gastric cancer development and progress, 2019-06 至 2022-02, 137,500 ,000韓元-約71.69萬元, 結題, 主持
(4) the National Research Foundation of Korea(NRF) , "General research program" （相當於國內面向項目）, 2016R1D1A1B03931195, Studies on the elucidation of function and signa ling pathway by identification of GBP2 interactome in myeloid leukemia, 2016-11 至 2019-10, 150,000 ,000韓元-約79.65 萬元, 結題, 主持
論文專著
[科研成果]-SCI/SCIE 論文
1. Hwanhui Lee,Yeo-Jung Kwon,Hanyong Jin,Heifeng Liu,Wonku Kang,Young-Jin Chun,Jeehyeon Bae,Hyung-Kyoon Choi. Anticancer activity and metabolic profile alterations by ortho-topolin riboside in in vitro and in vivo models of non-small cell lung cancer. FASEB Journal (2022). [SCI二區, Impact factor: 5.191, citation: 0]
2. Haifeng Liu, Hanyong Jin, Guenhwi Kim, Jeehyeon Bae. A low dose of bisphenol A stimulates estradiol production by regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells. Biochemical and Biophysical Research Communications (2021). [SCI三區, Impact factor: 3.575, citation: 0]
3. Heayyean Lee, Hwanhui Lee, Myeongsun Kim, Ji Young Park, Hanyong Jin, Kyungsoo Oh, Jeehyeon Bae, Young Yang*, Hyung-Kyoon Choi*. Integrative metabolomic and lipidomic profiling of lung squamous cell carcinoma for characterization of metabolites and intact lipid species related to the metastatic potential. Cancers (2021). [SCI二區, Impact factor: 6.639, citation: 0]
4. Yongyang Luo*, Hanyong Jin*, Je-Hyeong Kim, Jeehyeon Bae. Guanylate binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK. Oncogenesis (2021)[SCI二區, Impact factor: 7.485, citation: 0] [*Co-first author]
5. Eunkyoung Shin, Hanyong Jin, Dae-Shik Suh, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee. Response to Veitia et al.(Correspondence) The EMBO Journal (2021). [SCI一區, Impact factor: 11.598, citation: 0]
6. Eunkyoung Shin*, Hanyong Jin*, Dae-Shik Suh*, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, and Jeehyeon Bae. An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2. The EMBO Journal (2020). [SCI一區, Impact factor: 11.598, citation: 6] [*Co-first author]
7. Junho Ahn, Hanyong Jin, Jaehyeon Park, Boeun Lee, Mirae Ok, Ji Ha Lee, Jeehyeon Bae, Jong Hwa Jung. Coassembled Nanoparticles Composed of Functionalized Mesoporous Silica and Pillar[5]arene-Appended Gold Nanoparticles as Mitochondrial-Selective Dual-Drug Carriers. Particle & Particle Systems Characterization (2020). [SCIE二區, Impact factor: 3.310, citation: 4]
8. Jin H*, Lee B*, Luo Y, Choi Y, Choi EH, Jin H, Kim KB, Seo SB, Kim YH, Lee HH, Kim KP, Lee K, Bae J. FOXL2 Directs DNA Double-strand Break Repair Pathways by Differentially Interacting with Ku. Nature Communications (2020). [SCI一區, Impact factor: 14.919, citation: 12] [*Co-first author]
9. Sungjin Jeon*, Tae-Il Kim*, Hanyong Jin*, Jeehyeon Bae, Jean Bouffard, and Youngmi Kim. Amine-Reactive Activated Esters of meso-CarboxyBODIPY: Fluorogenic Assays and Labeling of Amines, Amino Acids, and Proteins. Journal of the American Chemical Society (2020). [SCI一區, Impact factor: 15.419, citation: 23] [*Co-first author]
10. Won M, Luo Y, Lee DH, Shin E, Suh DS, Kim TH, Jin H#, Bae J#. BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells. Biochemical and Biophysical Research Communications (2019). [SCI三區, Impact factor: 3.575, citation: 5] [#Co-corresponding author]
11. Kim HY, Jin H, Bae J, Choi HK. Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells. Scientific Reports (2019) [SCI三區, Impact factor: 4.379, citation: 6]
12. Ahn J, Lee B, Choi Y, Jin H, Lim NY, Park J, Kim JH, Bae J, Jung JH. Non-peptidic guanidinium-functionalized silica nanoparticles as selective mitochondria-targeting drug nanocarriers. Journal of Materials Chemistry B (2018) [SCI二區, Impact factor: 6.331, citation: 9]
13. Suh DS, Park SE, Jin H, Lee K, Bae J. LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle. Oncogenesis (2018). [SCI二區, Impact factor: 7.485, citation: 6]
14. Lee JH, Kim KY, Jin H, Baek YE, Choi Y, Jung SH, Lee SS, Bae J, Jung JH. Self-Assembled Coumarin Nanoparticle in Aqueous Solution as Selective Mitochondrial-Targeting Drug Delivery System. ACS Applied Materials & Interfaces (2018). [SCI一區, Impact factor: 9.229, citation: 27]
15. Kim TI, Jin H, Bae J, Kim Y. Excimer Emission-Based Fluorescent Probe Targeting Caspase-3. Analytical Chemistry (2017). [SCI一區, Impact factor: 6.986, citation: 27]
16. Ka Young Kim*, Hanyong Jin*, Jaehyeon Park, Sung Ho Jung, Ji Ha Lee, Hyesong Park, Sung Kuk Kim, Jeehyeon Bae, Jong Hwa Jung. Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery. Nano Research (2017). [SCI一區, Impact factor: 8.897, citation: 29] [*Co-first author]
17. Kim HY, Lee H, Kim SH, Jin H, Bae J, Choi HK. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Scientific Reports (2017). [SCI三區, Impact factor: 4.379, citation: 47]
18. Jin H*, Won M*, Shin E, Kim HM, Lee K, Bae J. EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells. Biochemical and Biophysical Research Communications (2016). [SCI三區, Impact factor: 3.575, citation: 9] [*Co-first author]
19. Jin H*, Won M*, Park SE, Lee S, Park M, Bae J. FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells. PLoS One (2016). [SCI三區, Impact factor: 3.240, citation: 17] [*Co-first author]
20. Jin H, Lee K, Kim YH, Oh HK, Maeng YI, Kim TH, Suh DS, Bae J. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene (2016). [SCI一區, Impact factor: 9.867, citation: 17]
21. Jin H*, Suh DS*, Kim TH, Yeom JH, Lee K, Bae J. IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity. Scientific Reports (2015). [SCI三區, Impact factor: 4.379, citation: 15] [*Co-first author]
22. Kim WH, Song HO, Jin CM, Hur JM, Lee HS, Jin HY, Kim SY, Park H. The Methanol Extract of Azadirachta indica A. Juss Leaf Protects Mice Against Lethal Endotoxemia and Sepsis. Evid. Based. Complement. Biomolecules & Therapeutics (Seoul) (2012). [SCIE三區, Impact factor: 4.634, citation: 7]
[科研成果]-專利(韓國)
1. miRNA-1236 for diagnosing and treating the granulosa cell tumor or endometrium cancer (Patent number: 10-2120659, Korea). 2020.06.03
2. Composition comprising 1-[2-(4-nitro-phenyl)-benz-oxsazol-5-yl]-propan-1-one(1124JH0013) for preventing and treating the disease caused by Toxoplasmosis and Coccidium. (Patent number: 10-1205713, Korea). 2012.11.22
3. Composition comprising 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindol-2-one(5-108) for preventing and treating the disease caused by Toxoplasmosis and Coccidium. (Patent number: 10-1146511, Korea). 2012.05.09
