賴毓霄

賴毓霄

賴毓霄(LAI Yuxiao),女,博士,研究員,中國科學院大學專職教師,中國科學院深圳先進技術研究院生物醫學與健康工程研究所副所長,轉化醫學研究與發展中心執行主任,廣東省醫用增材製造工程實驗室主任。亦是國家自然科學基金“優秀青年”基金獲得者、中科院青年創新促進會、廣東省科技創新青年拔尖人才。主要從事骨科相關生物材料的研究。

基本介紹

  • 中文名:賴毓霄
  • 國籍:中國
  • 畢業院校:復旦大學
  • 學位/學歷: 博士研究生
  • 職業:教師
教育背景,工作經歷,社會兼職,所獲榮譽,專利成果,出版信息,發表論文,發表著作,

教育背景

2005-09--2010-06 復旦大學 博士研究生
2003-09至2005-06,中山大學,化學與化學工程學院高分子科學系,理學碩士,
1999-09至2003-06,中山大學,化學與化學工程學院高分子科學系,理學學士

工作經歷

2018-11至今,中國科學院深圳先進技術研究院,生物醫學與健康工程研究所轉化醫學研究與發展中心,研究員
2018-09至今,中國科學院深圳先進技術研究院,生物醫學與健康工程研究所,所長助理
2018-03至今,中國科學院深圳先進技術研究院,生物醫學與健康工程研究所轉化醫學研究與發展中心,執行主任
2013-10至2018-10,中國科學院深圳先進技術研究院,生物醫學與健康工程研究所轉化醫學研究與發展中心,副研究員
2010-07至2013-09,中國科學院深圳先進技術研究院,生物醫學與健康工程研究所轉化醫學研究與發展中心,助理研究員

社會兼職

2022-10-01-2026-12-31,中國醫學裝備協會, 理事
2019-06-29-今,中國生物醫學工程學會青年委員會, 常務委員
2018-12-31-今,廣東省生物醫用材料增材製造工程, 主任
2018-09-01-今,華人骨研學會, 終身會員
2018-06-30-今,中國醫學裝備協會醫用增材製造專委會, 常務委員兼秘書
2016-03-01-2020-03-01,深圳市青年科技者協會, 常務理事
2015-06-01-2018-06-01,中國生物材料學會生物製造分會, 理事
2014-01-01-今,中國科學院青年創新促進會會員, 會員

所獲榮譽

2023年2月25日,被全國婦聯授予“全國巾幗建功標兵”稱號。

專利成果

( 1 ) 用於腫瘤治療的雙親性分子自組裝納米藥物及製備方法和用途, 發明專利, 2021, 第 3 作者, 專利號: CN112675305A
( 2 ) 一種骨用複合材料及其製備方法和套用, 發明專利, 2021, 第 2 作者, 專利號: CN112604033A
( 3 ) 一種具備光熱抗腫瘤及促成骨複合材料及其製備方法, 發明專利, 2021, 第 1 作者, 專利號: CN112516382A
( 4 ) 鎂鍶-磷酸矽鹽材料及製備方法、包含其的結構可控的多孔骨修復複合支架材料, 發明專利, 2020, 第 6 作者, 專利號: CN110776315A
( 5 ) 用於治療骨肉瘤的光熱骨修復材料及其套用, 發明專利, 2019, 第 1 作者, 專利號: CN110302421A
( 6 ) 一種磁性納米骨修復支架及其製備方法, 發明專利, 2019, 第 3 作者, 專利號: CN110227179A
( 7 ) 一種製備異質異構骨修復支架的3D列印裝置, 實用新型, 2019, 第 1 作者, 專利號: CN209285828U
( 8 ) 3D列印噴頭及智慧型控制3D列印噴頭, 專利授權, 2019, 第 1 作者, 專利號: CN106493945B
( 9 ) 3D列印設備和基於3D列印的物料供給攪拌系統, 專利授權, 2019, 第 1 作者, 專利號: CN105690757B
( 10 ) 3D列印方法, 發明專利, 2017, 第 1 作者, 專利號: CN105711090B
( 11 ) 3D列印噴頭及智慧型控制3D列印噴頭, 實用新型, 2017, 第 1 作者, 專利號: CN206484898U
( 12 ) 可形成納米複合骨水泥的組合物及其套用, 發明專利, 2017, 第 1 作者, 專利號: CN107050522A
( 13 ) 一種生物複合材料及其製備方法, 發明專利, 2016, 第 3 作者, 專利號: CN105727374A
( 14 ) 3D列印設備和基於3D列印的物料供給攪拌系統, 實用新型, 2016, 第 1 作者, 專利號: CN204977485U
( 15 ) 骨支架成型系統, 發明專利, 2014, 第 2 作者, 專利號: CN103876862A
( 16 ) 多孔性骨支架, 實用新型, 2013, 第 1 作者, 專利號: CN202751469U
( 17 ) 骨修復材料及其製備方法, 發明專利, 2012, 第 1 作者, 專利號: CN102824657A
( 18 ) 多孔性骨支架及其製備方法, 發明專利, 2012, 第 1 作者, 專利號: CN102784014A

出版信息

發表論文

(1) Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis, ACTA BIOMATERIALIA, 2023, 通訊作者
(2) PDGF-BB prevents destructive repair and promotes reparative osteogenesis of steroid-associated osteonecrosis of the femoral head in rabbits, BONE, 2023, 第 8 作者
(3) Integrated and Bifunctional Bilayer 3D Printing Scaffold for Osteochondral Defect Repair, ADVANCED FUNCTIONAL MATERIALS, 2023, 通訊作者
(4) Engineering Supramolecular Nanomedicine for Targeted Near Infrared-triggered Mitochondrial Dysfunction to Potentiate Cisplatin for Efficient Chemophototherapy, ACS NANO, 2022, 通訊作者
(5) Preparation and characterization of photocurable composite extracellular matrix-methacrylated hyaluronic acid bioink, JOURNAL OF MATERIALS CHEMISTRY B, 2022, 通訊作者
(6) Long-term mechanical loading is required for the formation of 3D bioprinted functional osteocyte bone organoids, BIOFABRICATION, 2022, 第 8 作者
(7) Brominated cyclometalated iridium(III) complexes for mitochondrial immobilization as potential anticancer agents, DALTON TRANSACTIONS, 2022, 通訊作者
(8) 3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration, BIOACTIVE MATERIALS, 2022, 通訊作者
(9) Biomechanics evaluation of sacroiliac joint pain after lumbosacral fusion: A finite element analysis, JOURNAL OF ORTHOPAEDIC RESEARCH, 2022, 通訊作者
(10) Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc, Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc, BONE RESEARCH, 2022, 第 9 作者
(11) Nanocomposite multifunctional hydrogel for suppressing osteosarcoma recurrence and enhancing bone regeneration, CHEMICAL ENGINEERING JOURNAL, 2022, 通訊作者
(12) Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy, APPLIED MATERIALS TODAY, 2022, 通訊作者
(13) Recent Advances of Microneedles and Their Application in Disease Treatment, INTERNATIONALJOURNALOFMOLECULARSCIENCES, 2022, 通訊作者
(14) Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy, APPLIED MATERIALS TODAY, 2021, 通訊作者
(15) Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review, Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review, ENGINEERING, 2021, 通訊作者
(16) An impaired healing model of osteochondral defect in papain-induced arthritis, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2021, 第 4 作者
(17) Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration, APPLIED MATERIALS TODAY, 2021, 通訊作者
(18) Article Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid)porous scaffolds by three-dimensional printing Jing, Article Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid)porous scaffolds by three-dimensional printing Jing, 生物材料轉化電子雜誌(英文), 2021, 第11作者
(19) Multifunctional magnesium incorporated scaffolds by 3D-Printing for comprehensive postsurgical management of osteosarcoma, BIOMATERIALS, 2021, 通訊作者
(20) Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal-Chemotherapy of Cancer, ACS APPLIED POLYMER MATERIALS, 2020, 通訊作者
(21) Animal Models of Osteochondral Defect for Testing Biomaterials, BIOCHEMISTRY RESEARCH INTERNATIONAL, 2020, 第 6 作者
(22) Preparation and evaluation of osteogenic nano-MgO/PMMA bone cement for bone healing in a rat critical size calvarial defect, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 通訊作者
(23) Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products, Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products, ENGINEERING, 2020, 第 38 作者
(24) Bioactive PLGA/tricalcium phosphate scaffolds incorporating phytomolecule icaritin developed for calvarial defect repair in rat model, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2020, 第 7 作者
(25) Innovative Tissue-Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges, ADVANCED HEALTHCARE MATERIALS, 2020, 第 5 作者
(26) Strong mineralization ability of strontium zinc silicate: Formation of a continuous biomorphic mineralized layer with enhanced osteogenic activity, COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 通訊作者
(27) Osteogenetic Mg Incorporated into PLGA/TCP Porous Scaffold by 3D Printing for Repairing Challenging Bone Defect, biomaterials, 2019, 通訊作者
(28) Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis, PHYTOMEDICINE, 2019, 第 8 作者
(29) Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect, BIOMATERIALS, 2019, 通訊作者
(30) PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model, BIOMATERIALS, 2019, 第 7 作者
(31) Use of a three-dimensional printed polylactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2019, 通訊作者
(32) PLGA/beta-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model, BIOMATERIALS, 2019, 第 7 作者
(33) Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold, MATERIALS SCIENCE & ENGINEERING C, 2018, 第 8 作者
(34) Fracture Healing in a Collagen-Induced Arthritis Rat Model: Radiology and Histology Evidence, JOURNAL OF ORTHOPAEDIC RESEARCH, 2018, 第 5 作者
(35) Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits, BIOMATERIALS, 2018, 通訊作者
(36) Physical stimulations and their osteogenesis-inducing mechanisms, Physical stimulations and their osteogenesis-inducing mechanisms, INTERNATIONAL JOURNAL OF BIOPRINTING, 2018, 第 6 作者
(37) Quantitative determination of residual 1,4-dioxane in 3D printed bone scaffold, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2017, 第 2 作者
(38) Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials:a review, Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review, REGENERATIVE BIOMATERIALS, 2017, 通訊作者
(39) Biological Evaluation of Three-dimensional Printed PLGA/TCP Scaffold for Jaw Restoration, Biological Evaluation of Three-dimensional Printed PLGA/TCP Scaffold for Jaw Restoration, 功能材料信息, 2016, 第 3 作者
(40) Review of various treatment options and potential therapies for osteonecrosis of the femoral head, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2016, 第 3 作者
(41) Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect, ACTA BIOMATERIALIA, 2016, 第 7 作者
(42) 三維列印聚乳酸-羥基乙酸/磷酸三鈣骨修復支架的生物學評價, Biological evaluation of three-dimensional printed co-poly lactic acid/glycolic acid/tri-calcium phosphate scaffold for bone reconstruction, 中華口腔醫學雜誌, 2016, 第 3 作者
(43) Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein, CURRENT PHARMACEUTICAL DESIGN, 2016, 第 5 作者
(44) Systemic Drug Delivery Systems for Bone Tissue Regeneration- A Mini Review, CURRENT PHARMACEUTICAL DESIGN, 2015, 第 2 作者
(45) Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds–an in vitro efficacy study, SCIENTIFIC REPORTS, 2015, 第 2 作者
(46) Antibacterial potential of 3D rapid-prototyped magnesium-based porous composite scaffolds–an in vitro efficacy study, Scientific Reports, 2015, 第 1 作者
(47) 基於3D列印技術的新型生物活性複合鎂骨修復支架, 國際骨科學雜誌, 2015, 第 2 作者
(48) Bone defect animal models for testing efficacy of bone substitute biomaterials, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2015, 第 6 作者
(49) The RAPIDOS projectd-European and Chinese collaborative research on biomaterials, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2015, 第 7 作者
(50) Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity – an in vitro mechanism study for preventing destructive repair of osteonecrosis, BONE, 2015, 第 7 作者
(51) Comparative study of poly (lactic-co-glycolic acid)/tricalcium phosphate scaffolds incorporated or coated with osteogenic growth factors for enhancement of bone regeneration, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2014, 第 5 作者
(52) A Novel magnesium composed PLGA/TCP porous scaffold fabricated by 3D printing for bone regeneration, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2014, 第 1 作者
(53) Effect of a novel bioactive porous PLGA/TCP/Icariin composite scaffold, European Cells and Materials, 2013, 通訊作者
(54) Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2013, 第 5 作者
(55) 新型表面活性改性人工腰椎融合器的研發新進展, 中國科技縱橫, 2012, 第 4 作者
(56) Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: A general review, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2012, 第 6 作者
(57) Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs, BIOMATERIALS, 2010, 第 1 作者
(58) Effects of immobilizing sites of RGD peptides in amphiphilic polymers on efficacy of cell adhesion, Biomaterials, 2010, 第 1 作者

發表著作

(1) 可降解金屬, 科學出版社, 2016-10, 第 5 作者
(2) 生物醫用高分子材料第14章, 科學出版社, 2022-02, 第 1 作者

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