葉健，現任中國科學院微生物研究所農業微生物組學與生物技術研究室主任。
基本介紹
- 中文名：葉健
- 國籍：中國
人物經歷,研究方向,主要成就,發表論文,國際專利,
人物經歷
學習經歷
2000–2007 中國科學院微生物研究所，博士
1996–2000 浙江大學農業與生物技術學院，學士
工作經歷
2023.08- 農業微生物組學與生物技術研究室，主任
2019-2023.08 農業微生物組學與生物技術研究室，副主任
2017- 中國科學院微生物研究所，研究組長
2014-2017 中國科學院微生物研究所，青年研究組長
2013-2014 新加坡國立大學淡馬錫生命科學研究院，Principal Investigator
2011-2013 新加坡國立大學淡馬錫生命科學研究院，Biotechnology Manager
2009-2010 新加坡國立大學淡馬錫生命科學研究院，Research Fellow
2007-2009 新加坡國立大學淡馬錫生命科學研究院，博士後
研究方向
1. 病原微生物—媒介昆蟲—宿主三者互作機制解析；
2. 植物抵禦病原感染免疫網路解析；
3. 蟲媒柑橘黃龍病的宿主抗病機制及抗病生物技術
主要成就
2025年4月，中國科學院微生物研究所葉健團隊成功解析柑橘抗黃龍病核心分子機制，並利用人工智慧（AI）技術篩選出可有效防控該病害的小肽。這項研究不僅破解了困擾國際農業界缺乏柑橘黃龍病抗性基因的科學難題，也為全球柑橘產業可持續發展提供了新的解決方案。該項成果作為封面文章於4月11日發表在《科學》（Science）上。
發表論文
（*通訊作者, #共同第一作者)
2024年
Wang D, Yin Y, Zhang X*, Ye J*, An interspecies recombinant sida yellow mosaic China virus isolate and betasatellite cause a leaf curl disease in tobacco in Hainan, China. 2024, 108 (877-886)
Yin Y, Wang D, Wang H, Sun Y, Ye J*. Development and application of sugarcane streak mosaic virus vectors. 2024. Virology, 593, 110028
Wu J, Zhang Y, Li F, Zhang X, Ye J,….Li Y. Plant Virology in the 21st Century in China: Recent Advances and Future Directions. 2024. Journal of Integrative Plant Biology, 66, 579-622
Zhang, X., Wang, D., Zhao, P., Sun, Y., Fang, R.-X., Ye, J*., Near infrared light and PIF4 promote plant antiviral defense by enhancing RNA interference, Plant Communications (2024), doi: https://doi.org/10.1016/j.xplc.2023.100644
2023年
Yin C, Yang L, Xin X, Ye J*, Liu, Q*. Identification of Flavobacterium algoritolerans sp. nov. and Flavobacterium yafengii sp. nov. International Journal of Systematic and Evolutionary Microbiology, 2023;73:006072
Tong X, Zhao JJ, Feng YL, Zou JZ, Ye J, Liu J, Han C, Li D, Wang X. A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors. Nature Communications, 2023 3852
Wang D#, Zhang X#, Yin YT, Chen DX* and Ye J*. First Report of Ludwigia Yellow Vein Vietnam Virus Causing LeafCurling on Tobacco Plants in Hainan Province, China. Plant Disease. 2023. Doi: 10.1094/PDIS-01-23-0034-PDN
Zhang X#, Wang D#, Zhao PZ, Sun YW, Fang RX and Ye J*. Near infrared light and PIF4 promote plant antiviral defense by enhancing RNA interference. Plant Communications. 2023. 100644
Wu X#, Zhang X#, Wang H, Fang R, and Ye J*. Structure-function analyses of coiled-coil immune receptors define a hydrophobic module for improving plant virus resistance. Journal Of Experimental Botany. 2023. 74(5): 1372-1388
2022年
Wang HW#, Wu XJ#, Huang XD, Wei SJ, Lu ZJ and Ye J*. Seed Transmission of Tomato Spotted Wilt Orthotospovirus in Peppers. Viruses. 2022. 14(9): 1873
Wang N#, Zhao PZ#, Wang D#, Mubin M, Fang RX and Ye J*. Diverse Begomoviruses Evolutionarily Hijack Plant Terpenoid-Based Defense to Promote Whitefly Performance. Cells. 2022. 30(12): 149
Chen GM#, Xuan W#, Zhao PZ#, Yao XM, Peng C, Tian YL, Ye J, Wang BX, He J, Chi WC, Yu J, Ge YW, Li J, Dai ZY, Xu DY, Wang CM, Wan JM. OsTUB1 confers salt-insensitivity by interacting with Kinesin13A to stabilize microtubule and ion transporter in rice. 2022. New Phytologist.
https://nph.onlinelibrary.wiley.com/doi/pdf/10.1111/nph.18282
Liu XL, Tian YL, Chi WC, Zhang HZ, Yu J, Chen GM, Wu W, Jiang XZ, Wang SS, Lin ZX, Xuan W, Ye J, Wang BX, Liu Y, Sun ZG, Xu DY, Wang CM, Wan JM. Alternative splicing of OsGS1;1 affects nitrogen-use efficiency, grain development, and amylose content in rice. 2022. The Plant Journal. https://doi.org/10.1111/tpj.15768
Wang D, Bishnu Dawadi, Qu J, Ye J*,Light-Engineering Technology for Enhancing Plant Disease Resistance. Front. Plant Sci. 2022. 12:805614
Wang D, Zhang X, Chen DX, Ye J*.First report of Sida leaf curl virus and associated betasatellite in tobacco. Plant Disease. 2022. 106: 1078
Mubin M, Shabbir A, Nahid N, Liaqat I, Hassan M, Aljarba NH, Al Qahtani A, Fauquet CM,Ye Jand Nawaz-ul-Rehman MS. Patterns of Genetic Diversity among Alphasatellites Infecting Gossypium Species. Pathogens. 2022. 11(7): 763
Nawaz-Ul-Rehman MS, Liaqat I, Nahid N, Saleem F, Alkahtani S, Al Qahtani A,Ye J, Mubin M*. Brazilian Journal of Biology. 2022. 82: e262248
2021年
Zhao PZ, Zhang X, Gong YQ, Wang D, Xu DQ, Wang N, Sun YW, Gao LB, Liu SS, Deng XW, Kliebenstein DJ, Zhou XP, Fang RX, and Ye J*Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly. PLoS Pathogens. 2021. 10.1371/journal.ppat.1008770
Zhao DN, Li YL, Song Y, Yang BJ, Ding X, Gao, F, Ye J, Hao XJ, Zhang Y, Li SL. Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities. Fitoterapia. 2021. 153. 104989
Ye J*, Zhang LL, Zhang X, Wu XJ, Fang RX*. Plant defense networks against insect-borne pathogens. Trends in Plant Science. 2021. 26 (3) 272-287
2020年
Li YL, Zhang Y, Zhao PZ, Hu ZX, Gu YC, Ye J*, Hao XJ*. Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity. Fitoterapia. 2020. 147. 104731
Wu XJ,Ye J*. Manipulation of Jasmonate Signaling by Plant Viruses and Their Insect Vectors. Viruses. 2020. 12(2), 148
王端，葉健*. 植物病毒資源屬性和套用基礎研究進展. 生物資源. 2020.42（1）1-8
Wang D, Zhang X, Yao XM, Zhang P, Fang RX, Ye J*. A 7-Amino-Acid Motif of Rep protein essential for virulence is critical for triggering host defense against Sri Lankan cassava mosaic virus. Molecular Plant-Microbe Interactions, 2020. Jan;33(1):78-86 DOI: 1094/MPMI-06-19-0163-FI
2019年
Zhao PZ, Yao XM, Cai CX, Li R, Du J, Sun YW, Wang MY, Zou Z, Wang QM, Kliebenstein DJ , Liu SS, Fang RX and Ye J*.Viruses mobilize plant immunity to deter non-vector insect herbivores. Science Advances. DOI: 10.1126/sciadv.aav9801
Wu XJ#, Xu S#, Zhao PZ, Zhang X, Yao XM, Sun YW，Fang RX, Ye J*.The Orthotospovirus nonstructural protein NSs suppresses plant MYC-regulated jasmonate signaling leading to enhanced vector attraction and performance. PLoS Pathogens. DOI:10.1371/journal.ppat.1007897
Wang N, Zhao PZ, Ma YH, Yao XM, Sun YW, Huang XD, Jin JJ, Zhang YJ, Zhu CX, Fang RX, Ye J*, A whitefly effector Bsp9 targets host immunity regulator WRKY33 to promote performance. Philos. Trans. Roy. Soc. B, 2019.374:20180313
Tang WJ#, Ye J#, Yao XM#, Zhao PZ, Xuan W, Tian YL, Zhang YY, Xu S, An HZ, Chen GM, Yu J, Wu W, Ge YW, Liu XL, Li J, Zhang HZ, Zhao YQ, Yang B, Jiang XZ, Peng C, Zhou C, Terzaghi W, Wang CM* & Wan JM* Genome-wide associated study identified NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice. Nature Communications. 2019.10(1):5279
2018年
Wang D, Yao, XM, Huang GX, Shi T, Wang GF, Ye J*, First report of Sri Lankan cassava mosaic virus infected cassava in China, Plant Disease 2018, DOI: 10.1094/PDIS-09-18-1590-PDN
Ye J*，Wang CM， Sun YW， Qu J， Mao HZ， Chua NH*. 2018.Overexpression of JcWRI1 in Jatropha elevated seed lipid content and increased seed mass. Frontiers in Plant Sciences, 2018.fpls.2018.01479
2017年
葉 健*，龔雨晴，方榮祥*，病毒—媒介昆蟲—植物三者互作研究進展及展望. 中國科學院院刊. 已接收
Sun YW#, Wang CM#,Wang N#, Jiang XY, Mao HZ, Zhu CX, Wen FJ, Wang XH, Lu ZJ, Yue GH, Xu ZF,Ye J*. 2017. Manipulation of Auxin Response Factor 19 affects seed size in the woodyperennial Jatropha curcas. Scientific reports. 7: 40844
Jin JJ,Sun YW#, Qu J, Rahmadsyah, Lim CH, Alfiko Y, NurEstyaBte Rahman, Suwanto A, Yue GH, Wong LS, Chua NH,Ye J*. 2017. Transcriptome and functional analysis reveals hybrid vigor for oil biosynthesis in oil palm. Scientific reports. 7: 439
2016年
Jun Liu#, Shulin Deng#, HW Wu#,Ye J, Hui-Wen Wu, Hai-Xi Sun, and Nam-Hai Chua.2016. CURLY LEAF Regulates Gene Sets Coordinating Seed Size and Lipid Biosynthesis in Arabidopsis. Plant physiology. 17 (1) 424-436
Tang W#, Wu T#,Ye J,Sun J, Jiang Y, Yu J, Tang J, Chen G, Wang C, Wan J.2016. SNP-based analysis of genetic diversity reveals important alleles associated with seed size in rice. BMC Plant Biology 16:93
Wang N#, Yao YM#, Zhu CX, Wen FJ*,Ye J*.2016Towards sustainable protection againstinsect-borneplant viral diseases: phytohormones and beyond. Science Foundation in China. 24(2). Review.Cover
Pingzhi Zhao, Lubomir N. Sokolov,Ye Jian, Cheng-Yi Tang, Jisen Shi, Yan Zhen, Wenzhi Lan, Zhi Hong, Jinliang Qi, Gui-Hua Lu, Girdhar K. Pandey & Yong-Hua Yang.2016The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis. Scientific reports. srep28683
Jin JJ#, Lee M#, Bai B#,Sun Yanwei#, Qu J, Rahmadsyah, Yuzer A, Lim CH, Suwanto A, Sugiharti M, Wong LS,Ye Jian*, Chua NH* and Yue GH*.2016Draft genome sequence of an elite Dura palm and whole-genome patterns of DNA variation in oil palm. DNA Research. 23:527
龔雨晴，姚香梅，徐爽，孫艷偉，王寧，馬永煥，趙平芝，應曉寶，葉健*. 微生物組學研究與經濟作物蟲傳病害的綠色防控.《植物保護與農產品安全》2016年12月
2015年
Ye J*, Yang J, Sun Y, Zhao P, Gao S, Jung C, Qu J, Fang R, Chua NH*.2015. Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. PLoS pathogens 11:e1005196
Sun YW#, Tee CS#, Ma YH#, Wang G, Yao XM, Ye J*.2015. Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus. Scientific reports 5:16476
Li R, Tee C, Jiang Y, Jiang X, Venkatesh P, Sarojam R, Ye J*. 2015. A terpenoid phytoalexin plays a role in basal defense of Nicotiana benthamiana against Potato virus X. Scientific reports 5:9682
Wang H NQ, Wu HW, Liu J, Ye J, Yu N, Chua NH.2015. Analysis of noncoding transcriptome in rice and maize uncovers roles of conserved lncRNAs associated with agriculture traits. The Plant Journal 84 2: 404-416
Lee M, Xia J, Zou Z, Ye J, Rahmadsyah, Alfiko Y, Jin J, Lieando J, Purnamasari M, Lim C, Suwanto A, Wong L, Chua N, Yue G.2015. A consensus linkage map of oil palm and a major QTL for stem height. Scientific reports 5:8232
2014年
Li R, Weldegergis BT, Li J, Jung C, Qu J, Sun Y, Qian H, Tee C, van Loon JJ, Dicke M, Chua NH, Liu SS, Ye J*.2014. Virulence factors of geminivirus interact with MYC2 to subvert plant resistance and promote vector performance. The Plant cell 26:4991-5008.
Ye J, Qu J, Mao HZ, Ma ZG, Rahman NE, Bai C, Chen W, Jiang SY, Ramachandran S, Chua NH.2014. Engineering geminivirus resistance in Jatropha curcus. Biotechnology for biofuels 7:149
Ye J, Geng Y, Zhang B, Mao H, Qu J, Chua N.2014. The Jatropha FT ortholog is a systemic signal regulating growth and flowering time.Biotechnology for biofuels7:19.
Ye J, Liu P, Zhu C, Qu J, Wang X, Sun Y, Sun F, Jiang Y, Yue G, Wang C.2014. Identification of candidate genesJcARF19andJcIAA9associated with seed size traits in Jatropha. Functional & integrative genomics 14:757-766
Wang G, Sun Y, Xu R, Qu J, Tee C, Jiang X,Ye J*.2014. DNA-A of a highly pathogenicIndian cassava mosaic virusisolated fromJatropha curcascauses symptoms inNicotiana benthamiana. Virus genes 48:402-405
2013年及以前
Wang C, Ye J, Tang W, Liu Z, Zhu C, Wang M, Wan J.2013.Loop nucleotide polymorphism in a putative miRNA precursor associated with seed length in rice (Oryza sativa L.). International journal of biological sciences 9:578-586
Wang CM, Liu P, Sun F, Li L, Liu P, Ye J, Yue GH.2012. Isolation and identification of miRNAs inJatropha curcas. International journal of biological sciences 8:418-429
Qu J,Ye J#, Geng YF, Sun YW, Gao SQ, Zhang BP, Chen W, Chua NH.2012. Dissecting functions ofKATANINandWRINKLED1in cotton fiber development by virus-induced gene silencing. Plant physiology 160:738-748
Ye J*, Hong Y, Qu J, Wang C. 2012.Improvement of Jatropha oil by genetic transformation. Jatropha, Challenges for a New Energy Crop- Genetic Improvement and Biotechnology, vol. 2. Springer Science Publishers, New York
Qu J, Mao HZ, Chen W, Gao SQ, Bai YN, Sun YW, Geng YF, Ye J*.2012. Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid. Biotechnology for biofuels5:10
Qu J, Ye J, Fang R. 2012.Artificial MicroRNAs for Plant Vir s Resistance, Antiviral Resistance in Plants: Methods and Protocols, Methods in Molecular Biology, vol. 894
Sun F, Liu P, Ye J, Lo LC, Cao S, Li L, Yue GH, Wang CM.2012. An approach for jatropha improvement using pleiotropic QTLs regulating plant growth and seed yield. Biotechnology for biofuels 5:42
Gao S, Qu J, Chua NH, Ye J*.2010. A new strain of Indian cassava mosaic virus causes a mosaic disease in the biodiesel cropJatropha curcas. Archives of virology 155:607-612.
Ye J, Qu J, Zhang JF, Geng YF, Fang RX.2009. A critical domain of theCucumber mosaic virus2b protein for RNA silencing suppressor activity. FEBS letters 583:101-106
Ye J, Qu J, Bui HT, Chua NH.2009. Rapid analysis ofJatropha curcasgene functions by virus-induced gene silencing. Plant biotechnology journal 7:964-976
Qu J,Ye J#, Fang R.2007.Artificial microRNA-mediated virus resistance in plants. Journal of virology81:6690-6699
Xu Y, Ye J#, Liu H, Cheng E, Yang Y, Wang W, Zhao M, Zhou D, Liu D, Fang R.2008. DNA-templated CMV viral capsid proteins assemble into nanotubes. Chemical Communications 1:49-51
Ye J, Liu L, Xue Y, Qu J, Gao G, Fang R.2007.Efficient depletion of multiple SARS-CoV mRNAs by a single small interfering RNA targeting the leader sequence. Progress in Biochemistry and Biophysics 34:1092-1100
國際專利
Jian Ye et al. 一種抗黃龍病植物的培育方法及其套用 (patent application PCT/CN2024/076842)
Jian Ye et al. 一類靶向蛋白降解的多肽及其套用（patent application PCT/CN2024/080958）
Jian Ye, et al. Transcriptome and functional analysis reveals a single gene hybrid vigor for oil yield in oil palm. (US Provisional Patent Application No. 62/082,341)
Jian Ye et al.. A method to enhance plant virus resistance. (United States patent, PCT/SG2014/00003)
Jian Ye et al. Control of pests in plants. (U.S. Patent Application US 2012/02400288A1).
Jian Ye et al. Virus induced gene silencing (VIGS) for functional analysis of genes in cotton. (United States Patent 20120096595)
Jian Ye et al. Functional analysis of Jatropha curcas genes. (United States Patent 20110265233).
Jian Ye et al. Genetic Transformation of Jatropha curcas. (United States Patent 20110247099 A1)
Jian Ye et al. Increasing cotton fiber length by manipulating transcription factor. (United States Patent PCT/SG2012/000139)
Jian Ye et al. Microsomal ω6 Oleate Desaturases. (U.S. patent application PCT/SG2011/000337)
