人物經歷
2014年獲得中國科學技術大學博士學位 (導師:劉世勇教授);
2017-2019年在香港科技大學從事香江學者計畫博士後研究 (導師:唐本忠院士);
2022年加入中國科學技術大學高分子科學與工程系。
主要成就
在J. Am. Chem. Soc. (4篇), Angew. Chem. Int. Ed. (3篇) 等期刊以第一/通訊作者發表論文40餘篇,曾分別被Nature出版社周刊SciBX 專欄評述、入選JACS亮點論文專欄並發文報導、入選德國套用化學VIP論文並被Wiley和Newswise分別發文報導、入選Research期刊2020最佳論文、受邀為Chemistry-A European Journal撰寫Concept論文等,SCI論文總引用5500餘次,H指數38;擔任Nat. Chem., Nat. Commun., Adv. Mater., ACS Nano, Adv. Funct. Mater.等期刊審稿人、擔任中國化學會高級會員、中國生物醫學工程學會青年委員、廣東省精準醫學套用學會分子影像分會常務委員、廣東省藥物手性專委會委員、Asian J. Pharm. Sci.青年編委等;主持多項國家自然科學基金,作為骨幹參加一項國家重點研發計畫項目;作為主要發明人獲授權10餘項中國發明專利。
主要研究方向
功能高分子與光學材料研究,包括生物醫用高分子、聚集誘導發光材料等;
創新生物醫藥與製劑開發,如聚前藥技術、功能蛋白、脂質體等;
生物醫學診療方案開發,涉及腫瘤、感染與炎症、鎮痛、抗衰修復等;
基於臨床與套用需求,重視源頭創新,設計構築新分子與新材料,探索生物醫學與材料科學中的關鍵問題;曾發展了一種“聚前藥Polyprodrug”策略,用於高效可控藥物遞送與疾病診療,引發基礎研究興趣與產業關注。
獲獎榮譽
1. 2020年獲評Research最佳論文獎
2. 2019年 廣州市珠江科技新星
3. 2017年 香江學者獎
4. 2016年 廣東省傑出青年基金獲得者
5. 2016年 廣東省特支科技創新青年拔尖人才(結題獲評優秀)
6. 2015年 中國科學院優秀博士學位論文
代表論著
1. C. Z. Song, M. L. Chen, J. J. Tan, J. Xu, Y. B. Zhang, G. Y. Zhang, X. L. Hu*, S. Y. Liu* ““Self-Amplified Cascade Degradation and Oxidative Stress Via Rational pH Regulation of Oxidation-Responsive Poly(ferrocene) Aggregates” Journal of the American Chemical Society 2023, 145, 17755-17766.
2.W. H. Wang, Y. T. Zhang, Z. S. Wang, X. P. Liu, S. Y. Lu, X. L. Hu* "A Native Drug-Free Macromolecular Therapeutic to Trigger Mutual Reinforcing of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction for Cancer Treatment" ACS Nano 2023, 17, 11023-11038.
3. J. Xu, J. J. Tan, C. Z. Song, G. Y. Zhang, X. L. Hu*, S. Y. Liu* "Self‐Immolative Amphiphilic Poly (ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy" Angewandte Chemie-International Edition 2023, 62, e202303829. (VIP paper, highlighted by Wiley Press Release and Newswise, respectively)
4.Q. Q. Shi, Z. Y. Deng, M. X. Hou, X. L. Hu*, S. Y. Liu* "Engineering precise sequence-defined polymers for advanced functions" Progress in Polymer Science 2023, 141, 101677.
5.Z. X. Wang, M. X. Zhan*, X. L. Hu* “Pulsed Laser Excited Photoacoustic Effect for Disease Diagnosis and Therapy” Chemistry-A European Journal 2022, 28, e202200042. (Invited Concept)
6.Z. X. Wang, M. X. Zhan, W. J. Li, C. Y. Chu, D. Xing*, S. Y. Lu, X. L. Hu*“Photoacoustic Cavitation-Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization-free Polymeric Nanocapsules” Angewandte Chemie-International Edition 2021, 60, 4720-4731. (ESI Highly Cited Papers)
7.C. Y. Wang, Wei Zhao, B. Cao, Z. X. Wang, Q. Zhou, S. Y. Lu, L. Lu, M. Zhan*, X. L. Hu*“Biofilm-Responsive Polymeric Nanoparticles with Self-adaptive Deep Penetration for In Vivo Photothermal Treatment of Implant Infection” Chemistry of Materials 2020, 32, 7725-7738.
8.C. Z. Yao, Y. M. Li, Z. X. Wang, C. Z. Song, X. L. Hu*, S. Y. Liu* “Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles” ACS Nano 2020, 14, 1919-1935.
9.X. L. Liu, M. G. Li, T. Han, B. Cao, Z. J. Qiu, Y. Y. Li, Q. Y. Li, Y. B. Hu, Z. Y. Liu, Jacky W. Y. Lam*, X. L. Hu*, B. Z. Tang* “In-situ Generation of Azonia-containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing” Journal of the American Chemical Society 2019, 14, 11259-11268.
10.D. Wang*, M. S. Lee, W. H. Xu, G. G. Shan, X. Y. Zheng*, Ryan T. K. Kwok, Jacky W. Y. Lam, X. L. Hu*, B. Z. Tang* “Boosting Non-Radiative Decay to Do Useful Work: Development of Multi-Modality Theranostic System from AIEgen” Angewandte Chemie-International Edition 2019, 58, 5628-5632. (ESI Highly Cited Papers)
11.X. L. Hu, X. Q. Zhao, B. Z. He, Z. Zhao, Z. Zheng, P. F. Zhang, X. J. Shi, Ryan T. K. Kwok, Jacky W. Y. Lam, A. J. Qin, B. Z. Tang* “A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization” Research 2018, 2018, 3152870. (Best Paper Award 2020)
12.X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* "Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals", Journal of the American Chemical Society 2015, 137, 362-368. (Highlighted by JACS Spotlights, doi: 10.1021/ja512889n; “ESI Highly Cited Papers”)
13.X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu* “Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery” Journal of the American Chemical Society 2013, 135, 17617-17629. (Highlighted by SciBX, doi: 10.1038/scibx.2013.1366; rated as “ESI Hot Papers”, “ESI Highly Cited Papers”)