程賽鳳，湖北孝感人，西湖大學生命科學學院特聘研究員、博士生導師。
基本介紹
人物經歷,科研成就,
人物經歷
2007年，就讀於華中農業大學生命科學與技術基地班。
2017年，獲得華中農業大學生物化學與分子生物學博士學位。
2018年—2023年，在以色列威茲曼科學研究所進行博士後研究。
2024年，入職西湖大學生命科學學院，任特聘研究員、博士生導師。
科研成就
- 科研綜述
程賽鳳博士證實，DNA去甲基化對原腸胚時期的大多數細胞分化程式來說是非必需條件，且DNA去甲基化更傾向於在全基因組範圍內微調基因的表達，而非傳統觀點認為的指導性作用。該研究也提供了一套解析胚胎髮育時期基因功能的方法，使得我們能夠有效區分基因的自主效應與非自主效應。
- 代表論文
1. Yoav Mayshar*, Ofir Raz*, Saifeng Cheng, Raz Ben-Yair, Ron Hadas, Netta Reines, Markus Mittnenzweig, Oren Ben-Kiki, Aviezer Lifshitz, Amos Tanay, Yonatan Stelzer. (2023). Time-aligned hourglass gastrulation models in rabbit and mouse. Cell 186, 2610-2627.e18. 10.1016/j.cell.2023.04.037.
2. Marko Dunjić*, Felix Jonas*, Gilad Yaakov*, Roye More, Yoav Mayshar, Yoach Rais, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Naama Barkai, Yonatan Stelzer. (2023). Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells. Nat Commun 14, 1–19. 10.1038/s41467-023-39477-3.
3. Saifeng Cheng, Yoav Mayshar, Yonatan Stelzer. (2023). Induced epigenetic changes memorized across generations in mice. Cell 186, 683–685. 10.1016/j.cell.2023.01.023.
4. Saifeng Cheng*, Markus Mittnenzweig*, Yoav Mayshar, Aviezer Lifshitz, Marko Dunjić, Yoach Rais, Raz Ben-Yair, Stephanie Gehrs, Elad Chomsky, Zohar Mukamel, Hernan Rubinstein, Katharina Schlereth, Netta Reines, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzer. (2022). The intrinsic and extrinsic effects of TET proteins during gastrulation. Cell 185, 3169-3185.e20.
5. Markus Mittnenzweig*, Yoav Mayshar*, Saifeng Cheng, Raz Ben-Yair, Ron Hadas, Yoach Rais, Elad Chomsky, Netta Reines, Anna Uzonyi, Lior Lumerman, Aviezer Lifshitz, Zohar Mukamel, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzer. (2021). A single-embryo, single-cell time-resolved model for mouse gastrulation. Cell 184, 2825-2842.e22. 10.1016/j.cell.2021.04.004.
6. Alejandro Aguilera-Castrejon*, Bernardo Oldak*, Tom Shani, Nadir Ghanem, Chen Itzkovich, Sharon Slomovich, Shadi Tarazi, Jonathan Bayerl, Valeriya Chugaeva, Muneef Ayyash, Shahd Ashouokhi, Daoud Sheban, Nir Livnat, Lior Lasman, Sergey Viukov, Mirie Zerbib, Yoseph Addadi, Yoach Rais, Saifeng Cheng, Yonatan Stelzer, Hadas Keren-Shaul, Raanan Shlomo, Rada Massarwa, Noa Novershtern, Itay Maza, Jacob H Hanna. (2021). Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis. Nature 593, 119–124. 10.1038/s41586-021-03416-3.
7. Saifeng Cheng, Feng Tan, Yue Lu, Xiaoyun Liu, Tiantian Li, Wenjia Yuan, Yu Zhao, Dao-Xiu Zhou. (2018). WOX11 recruits a histone H3K27me3 demethylase to promote gene expression during shoot development in rice. Nucleic Acids Res 46, 2356–2369. 10.1093/nar/gky017.
8. Shaoli Zhou,Wei Jiang, Fei Long, Saifeng Cheng, Wenjing Yang, Yu Zhao, and Dao-Xiu Zhou. (2017). Rice Homeodomain Protein WOX11 Recruits a Histone Acetyltransferase Complex to Establish Programs of Cell Proliferation of Crown Root Meristem. Plant Cell 29, 1088–1104. 10.1105/tpc.16.00908.
9. Yu Zhao*, Saifeng Cheng*, Yaling Song, Yulan Huang, Shaoli Zhou, Xiaoyun Liu, Dao-Xiu Zhou. (2015). The Interaction between Rice ERF3 and WOX11 Promotes Crown Root Development by Regulating Gene Expression Involved in Cytokinin Signaling. Plant Cell 27, 2469–2483. 10.1105/tpc.15.00227.
