毛洋

毛洋

毛洋，男，博士，中山大學藥學院教授、博士生導師，中山大學“百人計畫二期”引進人才。研究方向為基於質譜的生物大分子藥物分析，長期以來聚焦於分析與抗凝血藥物“肝素鈉”相關的多糖類生物大分子的活性成分及相關糖生物學，最近的研究工作包括結合基因編輯技術和高解析度質譜研究多糖與蛋白之間的相互作用、O-糖基化的生理病理學意義等。目前兼任廣東省藥物非臨床評價研究企業重點實驗室專職副主任，中國藥理學會分析藥理學專業委員會青年委員。以通訊作者或第一作者在國際著名期刊Nature Methods，Chemical Science，Analytical Chemistry，PNAS以及JBC發表論文多篇。

基本介紹

  • 中文名：毛洋
  • 職業：教師
  • 畢業院校：美國哈佛大學
  • 學位/學歷：博士
  • 職務：博士生導師
  • 職稱：教授
研究方向,承擔課題,人物經歷,教育經歷,工作經歷,代表論文,

研究方向

  1. 基於質譜的生物大分子藥物分析：
  • 與抗凝血藥物“肝素鈉”相關的多糖類生物大分子的活性成分分析及相關糖生物學；
  • 糖基化蛋白類藥物的體內分析。
2. 結合基因編輯技術和高解析度質譜的分析藥理學研究：
  • 糖基化的生理病理學研究；
  • 其他生物大分子動態修飾的生理病理功能學研究。

承擔課題

  1. 國家自然科學基金面上項目（2019-2022，主持，57萬）
  2. 國家自然科學基金重大研究計畫培育項目（2019-2021，主持，60萬）

人物經歷

教育經歷

2003 - 2009  美國哈佛大學  博士
1998 - 2002  清華大學    學士

工作經歷

2015 - 2017  丹麥哥本哈根大學  助理教授
2010 - 2014  美國波士頓大學   博士後

代表論文

  1. Chen Y-H, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP,Mao Y（毛洋）*, Clausen H*, and Yang Z*. GAGOme–A Cell-Based Method for Display of Glycosaminoglycans. Nature Methods, 2018.8.13, DOI: 10.1038(s41592-018-0086-z). (*共同通訊作者)
  2. Wang S,Mao Y（毛洋）, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. The Journal of biological chemistry 2018, 293(19): 7408-7422.
  3. Schulz MA, Tian W,Mao Y（毛洋）, Van Coillie J, Sun L, Larsen JS, Chen YH, Kristensen C, Vakhrushev SY, Clausen H, Yang Z. Glycoengineering design options for IgG1 in CHO cells using precise gene editing. Glycobiology 2018, 28(7): 542-549.
  4. Tykesson E,Mao Y（毛洋）*, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmstrom L, Malmstrom A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chemical Science 2016, 7(2): 1447-1456. (*通訊作者)
  5. Clausen TM, Pereira MA, Oo HZ, Resende M, Gustavson T,Mao Y（毛洋）, Sugiura N, Liew J, Fazli L, Theander TG, Daugaard M, Salanti A. Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting. Sensing and Bio-Sensing Research 2016, 9: 23-30.
  6. Ayres Pereira M, Mandel Clausen T, Pehrson C,Mao Y（毛洋）, Resende M, Daugaard M, Riis Kristensen A, Spliid C, Mathiesen L, L EK, Damm P, T GT, S RH, M AN, Salanti A. Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. PLoS pathogens 2016, 12(8): e1005831.
  7. Salanti A, Clausen TM, Agerbaek MO, Al Nakouzi N, Dahlback M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ,Mao Y（毛洋）, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M. Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Cancer cell 2015, 28(4): 500-514.
  8. Huang Y#,Mao Y（毛洋）#*, Zong C, Lin C, Boons GJ, Zaia J*. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Analytical chemistry 2015, 87(1): 592-600.(*共同通訊作者)
  9. Mao Y（毛洋）#, Huang Y#, Buczek-Thomas JA, Ethen CM, Nugent MA, Wu ZL, Zaia J. A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase. The Journal of biological chemistry 2014, 289(49): 34141-34151.
  10. Hu H, Huang Y,Mao Y（毛洋）, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Molecular & cellular proteomics : MCP 2014, 13(9): 2490-2502.
  11. Shi X, Shao C,Mao Y（毛洋）, Huang Y, Wu ZL, Zaia J. LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases. Glycobiology 2013, 23(8): 969-979.
  12. Huang Y, Yu X,Mao Y（毛洋）, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Analytical chemistry 2013, 85(24): 11979-11986.
  13. Shi X, Huang Y,Mao Y（毛洋）, Naimy H, Zaia J. Tandem mass spectrometry of heparan sulfate negative ions: sulfate loss patterns and chemical modification methods for improvement of product ion profiles. Journal of the American Society for Mass Spectrometry 2012, 23(9): 1498-1511.
  14. Mao Y（毛洋）, Xu X, Xu W, Ishida Y, Leal WS, Ames JB, Clardy J. Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(44): 19102-19107.

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