李陳龍，男，博士，中山大學生命科學學院教授、博士生導師，專業方向為表觀遺傳的生物信息學分析。
基本介紹
- 中文名：李陳龍
- 畢業院校：加拿大the University of Western Ontario
- 學位/學歷：博士
- 專業方向：表觀遺傳的生物信息學分析
- 任職院校：中山大學
研究方向,人物經歷,學術成就,承擔課題,論文專著,
研究方向
- 表觀遺傳的生物信息學分析。
- 基因表達調控的表觀遺傳機制。
- 染色體重塑因子識別靶標基因的分子機理。
- 種子壽命與活力的表觀遺傳調控。
人物經歷
2017年-至今 中山大學生命科學學院 教授
2015-2017 加拿大農業部 倫敦研發中心 研究科學家
2015 加拿大the University of Western Ontario生物系 博士後
2010-2014加拿大the University of Western Ontario生物系 博士
2006-2009 中山大學生命科學學院 碩士
2001-2005 南昌大學生命科學與食品學院 本科
學術成就
多年來在表觀遺傳學、發育生物學和逆境生物學領域進行研究，近期的研究集中在染色體重塑因子及組蛋白去甲基化酶的作用機理及其在生長發育與逆境反應的作用，以第一作者身份在Nature Genetics, Nature Plants, PLoS Genetics, The Plant Cell, Plant Biotechnology Journal,Journal of Experimental Botany等刊物上發表系列研究論文。
承擔課題
國家自然科學基金面上項目 （2019-2022）60萬 主持
中組部高層次人才項目 （2017-2020）200萬 主持
中山大學“百人計畫二期”（2017-2019）300萬 主持
中山大學青年教師重點培育項目 （2018-2020） 30萬 主持
論文專著
2019年
Chen C, Shu J,Li C, Thapa RK, Nguyen V, Yu K, Yuan ZC, Kohalmi SE, Liu J, Marsolais F, Huang S, Cui Y.(2019) RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis.Nucleic Acids Res.47(13):6714-6725
Hung FY,Chen FF,Li C,Chen C,Chen JH,Cui Y,Wu K. (2019) The LDL1/2-HDA6 histone modification complex interacts with TOC1 and regulates the core circadian clock components inArabidopsis.Frontiers in Plant Science. 10:233.
Li C#，*, Nguyen V*, Liu J*, Fu W, Chen C, Yu K, Cui Y#. (2019) Mutagenesis of seed storage protein genes in Soybean using CRISPR/Cas9.BMC Research Notes. 12:176.#: co-first author,#: Corresponding author
Jie Shu, Chen Chen, Raj Kumar Thapa, Shaomin Bian, Vi Nguyen, Kangfu Yu, Ze-Chun Yuan, Jun Liu, Susanne E. Kohalmi,Chenlong Li#, Yuhai Cui#. (2019) Genome-wide occupancy of histone H3K27 methyltransferases CURLY LEAF and SWINGER inArabidopsisseedlings.Plant Direct. 3:1-14.#: Corresponding author
2018年
Hung FY, Chen FF,Li C, Chen C, Lai YC, Chen JH, Cui Y, Wu K. (2018) The Arabidopsis LDL1/2-HDA6 histone modification complex is functionally associated with CCA1/LHY in regulation of circadian clock genes.Nucleic Acids Research. doi: 10.1093/nar/gky749
Li C#*, Chen C*, Chen H, Wang S, Chen X, and Cui Y.(2018)Verification of DNA motifs inArabidopsisusing CRISPR/Cas9 mediated mutagenesis.Plant Biotechnology Journal.*: co-first author;#: Corresponding author
2017年
Chen C*,Li C*, Wang Y, Tian G, Saatian B, Nguyen V, Hannoufa A, Austin R. S.,Kohalmi S.E.,Wu K, Huang S and Cui Y.(2017)Cytosolic acetyl-CoA promotes histone H3 lysine 27 acetylation inArabidopsis.Nature Plants3,814–824. *: co-first author
2016年
Li Cand Cui Y. (2016) A DNA element that remembers winter.Nature Genetics48(12): 1451-1452.
Li C,Gu L, Gao L, Chen C,Wei, C-Q, Qi Q, Chien C-W, Wang S, Jiang L, Ai L-F, Chen C-Y, Yang S,Nguyen V, Qi Y, Snyder M.P., Burlingame A.L., Kohalmi S.E., Huang S, Cao X, Wang Z-Y., Wu K, Chen X, and Cui Y. (2016)Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodelingATPaseBRM inArabidopsis.Nature Genetics48(6): 687-693.doi:10.1038/ng.3555.
Xu Y, Guo C, Wang H, Zhou B, Zheng B, Ding H, Zhu Z, Peragine A, Poethig R, S,Li C, Cui YandWu G. (2016) Regulation of vegetative phase change by SWI2/SNF2 chromatin remodeling ATPase BRAHMA inArabidopsis.Plant Physiology172:2416-2428.
2015年
Li C,Chen C,Gao L, Yang S, Nguyen V, Shi X, Siminovitch K, Kohalmi S.E., Huang S, Wu K, Chen X, and Cui Y. (2015)The Arabidopsis SWI2/SNF2 chromatin remodeler BRAHMA regulates polycomb function during vegetative development and directly activates the flowering repressor gene SVP.PLoS Genetics11(1): e1004944.
Yang S*,Li C*, Zhao L*, Gao S, Lu J, Zhao M, Chen C-Y, Liu X, Luo M, Cui Y, Yang C and Wu K. (2015) TheArabidopsisSWI2/SNF2 chromatin remodeling ATPase BRAHMA targets directly to PINs and is required for root stem cell niche maintenance.Plant Cell27:1670-1680. *: co-first author
Zhao M, Yang S, Chen C-Y,Li C, Shan W, Lu W, Cui Y, Liu X, and Wu K. (2015)ArabidopsisBREVIPEDICELLUS interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA to regulate KNAT2 and KNAT6 expression in control of inflorescence architecture.PLoS Genetics11(3): e1005125.
Before 2014
Zhou Y, Tan B, Luo M, Li Y, Liu C, Chen C, Yu CW, Yang S, Dong S, Ruan J, Yuan L, Zhang Z, Zhao L,Li C, Chen H, Cui Y, Wu K, and Huang S.(2013) HISTONE DEACETYLASE19 interacts with HSL1 and participates in the repression of seed maturation genes inArabidopsisseedlings.Plant Cell25:134-148.
Elhiti M,Hebelstrup KH,Wang A,Li C,Cui Y,Hill RD,and Stasolla C.(2013) Function of type-2Arabidopsishemoglobin in the auxin-mediated formation of embryogenic cells during morphogenesis.Plant Journal74: 946-958.
Fu G, Zhong Y,Li C, Li Y, Lin X, Liao B, Tsang EW, Wu K, and Huang S.(2010) Epigenetic regulation of peanut allergen gene Ara h 3 in developing embryos.Planta231:1049-1060.
Li C*, Wu K*,Fu G, Li Y, Zhong Y, Lin X,Zhou Y, Tian L,andHuang S. (2009)Regulation ofoleosinexpression in developing peanut (Arachis hypogaea L.) embryos through nucleosomelossandhistonemodifications.JournalofExperimental Botany60: 4371-4382. *: co-first author.
