李家昆，男，博士，湖南大學化學化工學院教授、博士生導師，畢業於中國科學技術大學。
基本介紹
人物經歷,教育經歷,工作經歷,研究領域,學術成果,
人物經歷
教育經歷
2009.09–2014.06 中國科學技術大學-中科院上海有機所聯合培養，理學博士，導師：俞飈研究員
2005.09–2009.07 黑龍江大學，理學學士, 導師：馬東升教授
工作經歷
2019.09–至今 湖南大學化學化工學院 教授，博士生導師
2015.05–2019.06 德國馬普煤炭所（MPI für Kohlenforschung）、哈佛大學， 博士後，導師：Tobias Ritter教授
2014.07–2015.04 中國科學院上海有機化學研究所，助理研究員， 導師：俞飈研究員
研究領域
1. 新型有機氟代反應
3. 18F-PET分子影像探針的合成及臨床套用
學術成果
迄今發表國際期刊文章10篇，以第一/共同第一作者在Nature, Nature Chemistry, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等國際權威期刊發表論文6篇。研究成果被C&EN、BioCentury及F1000Prime等專題報導。
1. Jiakun Li, Junting Chen, Ruocheng Sang, Won-Seok Ham, Matthew B. Plutschack, Florian Berger, Sonia Chabbra, Alexander Schnegg, Christophe Genicot and Tobias Ritter*. “Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination” Nature Chemisty , doi.org/10.1038/s41557-019-0353-3.
2. Junting Chen, Jiakun Li, Matthew B. Plutschack, Florian Berger and Tobias Ritter*. “Regio- and Stereoselective Thianthrenation of Olefins to Access Versatile Alkenyl Electrophiles” Manuscript submitted.
3. Kumiko Yamamoto?, Jiakun Li?, Jeffrey A. O. Garber, Julian D. Rolfes, Gregory B. Boursalian, Jannik C. Borghs, Christophe Genicot, Jér?me Jacq, Maurice van Gastel, Frank Neese and Tobias Ritter*. “Palladium-catalyzed electrophilic aromatic C–H fluorination” Nature, 2018, 554, 511–514 (?equal contribution).
4. Neil P.J. Price*, Trina M. Hartman, Jiakun Li, Kiran K. Velpula, Todd A. Naumann, Biao Yu, Kenneth M. Bischoff. “Modified Tunicamycins with Reduced Toxicity that Enhance the Antibacterial Activity of β-Lactams.” The Journal of Antibiotics, 2017, 70, 1070–1077.
5. Neil P.J. Price*, Michael A Jackson, Karl E Vermillion, Judith A Blackburn, Jiakun Li and Biao Yu. “Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors” The Journal of Antibiotics, 2017, 70, 1122–1128.
6. Nathaniel W. Goldberg, Xiao Shen, Jiakun Li and Tobias Ritter* “AlkylFluor: Deoxyfluorination of Alcohols” Org. Lett. 2016, 18, 6102–6104.
7. Jiakun Li and Biao Yu*. “A Modular Approach to the Total Synthesis of Tunicamycins” Angew. Chem. Int. Ed. 2015, 54, 6618–6621.
8. Jiakun Li, Yuanwei Dai, Laval Stéphane, Wei Li, Peng Xu and Biao Yu*. “Effective Synthesis of α-D-GlcN-(1?4)-D-GlcA/L-IdoA Glycosidic Linkage under Gold(I) Catalysis” The Asian Journal of Organic Chemistry, 2015, 4, 756–762.
9. Yu Tang?, Jiakun Li?, Yugen Zhu, Yao Li and Biao Yu*. “Mechanistic Insights into the Gold(I)-Catalyzed Activation of Glycosyl ortho-Alkynylbenzoates for Glycosidation” J. Am. Chem. Soc. 2013, 135, 18396–18405 (?equal contribution).
10. Jiakun Li, Wei Li* and Biao Yu*. “A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction” Org. Biomol. Chem. 2013, 11, 4971–4974.
