李孔寧

李孔寧，三級教授、博士生導師、海南省拔尖人才、海南醫學院生物信息學專業負責人、熱帶轉化醫學教育部重點實驗室學術骨幹、海南省首批100個人才團隊（熱帶疾病組學大數據創新研究團隊）核心成員。

目前研究方向是複雜疾病多組學數據及生物標誌物研究，從事編碼RNA和非編碼RNA分子的競爭或協同調控作用、多維組學數據整合分析、自噬相關RNA的數據挖掘及其在癌症中的調控作用、生物信息學資料庫的構建、生物學網路拓撲分析和癌症分子診斷等方面研究工作。

從事生物信息學、計算機軟硬體、儀器儀表、顯示驅動與控制等研究30多年。曾留學日本、加拿大10年，並在AMD、ATI等國際知名高科技公司擔任高級工程師和項目負責人。主持了國家自然科學基金、省重大科技計畫（子課題）、省重點研發、省高層次人才等項目。有10多項科技創新獲得了多個國家或地區的專利授權，發表科研論文50多篇。國內第一個“帶有無線數傳功能的電子鑽井參數監控儀表與系統”成果獲得國家火炬計畫立項推廣，多項專利被AMD公司、IGNIS（加拿大）創新技術公司推廣套用。出國前曾任中國醫學物理學會理事、黑龍江省電子學會理事，現任黑龍江省生物信息學會理事、海南省免疫學會腫瘤免疫專業委員會副主任委員、海南醫學院學術委員會委員。

基本介紹

教育經歷,工作經歷,科研項目,

教育經歷

1986.09 - 1989.07, 中國科學院上海技術物理研究所, 半導體物理, 碩士
1982.09 - 1986.07, 黑龍江大學, 理論物理, 學士

工作經歷

2018.12 - 至今, 海南醫學院, 生物醫學信息與工程學院, 教授
2009.6 - 2018.12, 哈爾濱醫科大學, 生物信息科學與技術學院, 教授
2006.11 - 2009.06, IGNIS創新技術公司（加拿大）, 顯示控制技術部, 高級工程師
2005.08 - 2006.11, AMD公司（加拿大）, 便攜技術研發部, 高級工程師
1999.06 - 2005.08, 凸版技術設計中心（日本）, 顯示控制技術部, 數字設計擔當
1989.07 - 1999.06, 哈爾濱醫科大學, 基礎醫學院物理教研室, 助教、講師、副教授

科研項目

1.海南省科技廳，海南省重大科技計畫項目，基於臨床生物樣本大數據的腫瘤患者個體化診療體系構建-基於腫瘤生物大數據的腫瘤動態演進及調控機制研究，2021-2024, ZDKJ2021040，分課題主持
2.國家自然科學基金委員會，地區基金項目，DNA甲基化相關lncRNA在兒童中樞神經系統腫瘤中的免疫調控機制研究，32160152，2022-01至2025-12，主持
3.海南省科技廳，海南省重點研發計畫項目，腫瘤FOX家族及其關鍵基因FOXM1的多組學分子特徵研究，ZDYF2021SHFZ097，2021-09至2023-09，主持
4.海南醫學院人才科研啟動費，2021.5-2026.4，主持
5.海南省科技廳，海南省自然科學基金高層次人才項目，820RC637，基於泛癌失調ceRNA互作網路解析表觀調控lncRNA的功能，2020-12至2023-12，主持
6.海南省科技廳，海南省重大科技計畫項目，ZDKJ202003，海南省重大傳染病關鍵防控技術研究與套用，2020-12至2023-12，參加
7.國家自然科學基金委員會，青年基金項目，31501075，動態差異DNA甲基化驅動的泛癌風險因子識別及其作用機制研究，2016-01至2018-12，參加（第一）
8.黑龍江省科技廳，黑龍江省自然科學基金重點項目，ZD201114，用於無標記生物電泳檢測的薄膜電晶體電荷感測器的研究，2012-01至2014-12，主持
9.黑龍江省教育廳，海外學人項目，1155H012，複雜疾病基因識別系統融合分析方法，2011-01至2013-12，主持
代表性論文
1.Meng Cao#, Liqiang Wang #, Dahua Xu#, Xiaoman Bi#, Shengnan Guo, Zhizhou Xu, Liyang Chen, Dehua Zheng, Peihu Li, Jiankai Xu, Shaojiang Zheng, Hong Wang, Bo Wang*, Jianping Lu*, Kongning Li*（李孔寧）: The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines, Computational and Structural Biotechnology Journal, 2022.9.12
2.Dahua Xu#, Zhizhou Xu#, Xiaoman Bi#, Meng Cao, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Deng Wu*, Jun Yang*, Kongning Li*（李孔寧）: Identification and functional analysis of N6-methyladenine (m6A)-related lncRNA across 33 cancer types, Cancer Medicine, 2022.6.20
3.Yongsheng Li, Sicong Xu, Dahua Xu, Tao Pan, Guo Jing, Shuo Gu, Qiuyu Lin, Xia Li*, Kongning Li*（李孔寧） and Wei Xiang*：Pediatric pan-central nervous system tumors methylomes analyses reveal immune-related lncRNAs，Frontiers in Immunology，2022.5.4
4.Xiaorong Yu, Jiankai Xu*, Dahua Xu, Xiaoman Bi, Hong Wang, Yanda Lu, Meng Cao, Wenxiang Wang, Zhizhou Xu, Dehua Zheng, Liyang Chen, Xiaodian Zhang, Shaojiang Zheng*, Kongning Li*（李孔寧）：Comprehensive analysis of the carcinogenic process, tumor microenvironment and drug response in HPV-positive cancers，Frontiers in Oncology，2022.3.22
5.Si Li , Weiwei Zhou , Donghao Li, Tao Pan, Jing Guo, Haozhe Zou, Zhanyu Tian, Kongning Li（李孔寧）, Juan Xu*, Xia Li *, Yongsheng Li *：Comprehensive characterization of human-virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs，Computational and Structural Biotechnology Journal, 2022.3.7
6.Shengnan Guo, Tianhao Li, Dahua Xu, Jiankai Xu, Hong Wang, Jian Li, Xiaoman Bi, Meng Cao, Zhizhou Xu, Qianfeng Xia*, Ying Cui*, Kongning Li*（李孔寧）：Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability Related Dysregulated CeRNA with Lung Adenocarcinoma，Frontiers in Molecular Biosciences，2022.3.28
7.Ke Xu, Dahua Xu, Hua Pei, Yunfan Quan, Jun Liu, Li Yin, Xuexia Li, ShenTian, Kongning Li *（李孔寧）and Qianfeng Xia*：Whole Blood Transcriptome Analysis Reveals the Correlation between Specific Immune Cells and Septicemic Melioidosis，Disease Markers，2021.10.13
8.Dahua Xu, Shun Ding, Meng Cao, Xiaorong Yu, Hong Wang, Dongqin Qiu, Zhengyang Xu, Xiaoman Bi*, Zhonglin Mu* and Kongning Li*（李孔寧）：A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors，Frontiers in Genetics，2021.9.17
9.Dahua Xu, Liqiang Wang, Sainan Pang, Meng Cao, Wenxiang Wang, Xiaorong Yu, Zhizhou Xu, Jiankai Xu, Hong Wang*, Jianping Lu* and Kongning Li*（李孔寧）: The functional characterization of epigenetically regulated lncRNAs involved in dysregulated ceRNA-ceRNA networks across 8 cancer types, Frontiers in Cell and Developmental Biology, 2021.6.17 Chunhua Li, Xiaorong Yu, Jianping Lu, Liyu Zheng, Dahua Xu, Zelong Xu, Liqiang Wang, Ying Cui, Yeshuang Li, Hong Wang*, Jiankai Xu*, and Kongning Li*（李孔寧）：Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression，BioMed Research International, 2020.3.20
10.Chunrui Zhang, Jing Jiang, Liqiang Wang, Liyu Zheng, Jiankai Xu, Xiaolin Qi, Huiying Huang, Jianping Lu*, Kongning Li*（李孔寧） and Hong Wang*：Identification of Autophagy-Associated Biomarkers and Corresponding Regulatory Factors in the Progression of Colorectal Cancer, Frontiers in Genetics, 2020.3.18, 11(245)
11.Kun Qian, Huiying Huang, Jing Jiang, Dahua Xu, Shengnan Guo, Ying Cui, Hao Wang, Liqiang Wang* and Kongning Li*（李孔寧）：Identifying autophagy gene-associated module biomarkers through construction and analysis of autophagy-mediated ceRNA-ceRNA interaction network in colorectal cancer，International Journal of Oncology，2018.6.18，53(3):1083-1093
12.Hong Wang, Dahua Xu, Huiying Huang, Ying Cui, Chunhua Li, Chunrui Zhang, Shengnan Guo, Lining Zhang, Xiaomu Xu, Jiankai Xu, Jianping Lu, Liqiang Wang* and Kongning Li*（李孔寧）: Detection of dysregulated competing endogenous RNA modules associated with clear cell kidney carcinoma, Molecular Medicine Reports, 2018.6.19，18(2):1963-1972
13.Ting Zhang, Puwen Tan, Liqiang Wang, Nana Jin, Yana Li, Lin Zhang,Huan Yang, Zhenyu Hu, Lining Zhang, Chunyu Hu, Chunhua Li, Kun Qian, Changjian Zhang, Yan Huang, Kongning Li*（李孔寧）, Hao Lin* and Dong Wang*：RNALocate: a resource for RNA subcellular localizations，Nucleic Acids Research, 2016.8.19, D135–D138
14.Yanhui Li, Changliang Wang1, Zhengqiang Miao, Xiaoman Bi, Deng Wu, Nana Jin1, Liqiang Wang, HaoWu, Kun Qian, Chunhua Li, Ting Zhang, Chunrui Zhang, Ying Yi, Hongyan Lai, Yongfei Hu, Lixin Cheng, Kwong-Sak Leung, Xiaobo Li, Fengmin Zhang, Kongning Li*(李孔寧), Xia Li*, and Dong Wang*: ViRBase: a resource for virus–host ncRNA-associated Interactions, Nucleic Acids Research, 2015.1, D578-82
15.Nana Jin，Hao Wu, Zhengqiang Miao, Yan Huang, Yongfei Hu, Xiaoman Bi, Deng Wu,Kun Qian, Liqiang Wang, Changliang Wang, Hongwei Wang, Kongning Li*（李孔寧）, Xia Li* & Dong Wang*：Network-based survival-associated module biomarker and its crosstalk with cell death genes in ovarian cancer，Scientific Reports，2015.6.23，5:11566
16.Liqiang Wang, Kun Qian, Yan Huang, Nana Jin, Hongyan Lai, Ting Zhang, Chunhua Li, Chunrui Zhang, Xiaoman Bi, Deng Wu, Changliang Wang, Hao Wu, Puwen Tan, Jianping Lu, Liqun Chen*, Kongning Li*(李孔寧), Xia Li*, and Dong Wang*：SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology，Scientific Reports，2015.1.28, 5:8090
17.Yun Wu, Nana Jin, Haiyang Zhu, Chunmiao Li, Nannan Liu, Yan Huang, Zhengqiang Miao, Xiaoman Bi, Deng Wu, Xi Chen, Yun Xiao, Dapeng Hao, Chuanxing Li, Binsheng Gong, Shaojun Zhang, Liwei Zhuang*, Kongning Li*(李孔寧) and Dong Wang*: Global gene expression distribution in non-cancerous complex diseases, Molecular BioSystems 2014.3.10, 10(4):728-31
18.Xu Jia, Zhengqiang Miao, Wan Li, Liangcai Zhang, Chenchen Feng, Yuehan He, Xiaoman Bi, Liqiang Wang, Youwen Du, Min Hou, Dapeng Hao, Yun Xiao, Lina Chen*, Kongning Li*(李孔寧)：Cancer-risk Module Identification and Module-based Disease Risk Evaluation: A Case Study on Lung Cancer，PLOS ONE, 2014.3.18, 9(3):e92395
19.Nana Jin, Deng Wu, Yonghui Gong, Xiaoman Bi, Hong Jiang, Kongning Li*(李孔寧) and Qianghu Wang*：Integration Strategy Is a Key Step in Network-Based Analysis and Dramatically Affects Network Topological Properties and Inferring Outcomes，BioMed Research International，2014, 2014:296349
20.Kongning Li(李孔寧), Deng Wu, Xi Chen, Ting Zhang, Lu Zhang, Ying Yi, Zhengqiang Miao, Nana Jin, Xiaoman Bi, Hongwei Wang*, Jianzhen Xu*, and DongWang*: Current and Emerging Biomarkers of Cell Death in Human Disease, BioMed Research International, 2014, 2014:690103
獲授權智慧財產權：
1.李孔寧；畢小慢；吳鄧；許達華等；Lnc2m6A：癌症N6-甲基腺嘌呤相關lncRNA綜合信息平台，2022-5-31,2022SR0677015（軟體著作權）
2.李孔寧; 陳宏; 王利強; 吳宇晗; 一種無創雙水平呼吸機遠程信號調控系統, 201 8-2-2, 中國, ZL201720087071.9. (專利)
3.王凱; 李孔寧; 一種生物大分子荷質比的測量裝置及方法, 2016-4-20, 中國, ZL201520863324.8. (專利)
4.李孔寧; 鄭晟; 王利強; 苗正強; 王棟; 張紹軍; 李霞; 一種攜帶型體徵信號監 測裝置, 2014-9-17, 中國, ZL201420033857.9. (專利)
5.李孔寧; 王凱; 夏國傑; 宮濱生; 杜磊; 李霞; 一種電泳成分分析方法和系統, 2 013-4-24, 中國, ZL201010263477.0. (專利)
6.Kongning Li; Gupta Cupertino; Gholamreza Chaji; Arokia Nathan; DRIVING SYSTEM FOR ACTIVE-MATRIX DISPLAYS, 2015-1-20, 美國, US 8,937,632 B2. (專利)
7.G.Eeza Chaji; Kongning Li; Vasudha Gupta; Arokia Nathan; Method and system for driving light emitting display , 2013-6-25, 美國, US 8,471,875 B2. (專利)
8.Kongning Li; Charles Leung; Grigori Temkine; Milivoje Aleksic; Steven ;Turner; Greg Vansickle; Kevin O'Neil Reduced component digital to analog decoder and method , 2011-10-4, 美國, US 8,031,093 B2. (專利)
9.Kongning Li; Vasudha Gupta; G. Reza Chaji; IMPLEMENTATION OF HYBRID DRIVING SCHEME WITH MULTIPLE GAMMA CURVES, 2011-3-9, 加拿大, CA 2678509. (專利)
10.G. Reza Chaji; Kongning Li; Arokia Nathan; IMPROVING THE DISPLAY SOURCE DRIVER, 2010-1-29, 加拿大, CA 2637343. (專利)

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