早幼粒細胞白血病蛋白

早幼粒細胞白血病蛋白是指可能的轉錄因子可能的轉錄因子(英語Probable transcription factor PML),是一個由人類基因PML編碼的抑癌蛋白。

基本介紹

  • 中文名:早幼粒細胞白血病蛋白
  • 外文名:Probable transcription factor PML
  • 類別:由人類基因PML編碼的抑癌蛋白
  • 有效結構PDB直系同源檢索:PDBe,RCSB
早幼粒細胞白血病蛋白
Promyelocytic leukemia
早幼粒細胞白血病蛋白

PDBrendering based on 1bor.
有效結構
PDB直系同源檢索:PDBe,RCSB
[隱藏]PDB查詢代碼列表
1BOR
[隱藏]PDB查詢代碼列表
1BOR
代號
PML; MYL; PP8675; RNF71; TRIM19
擴展標識
遺傳學:102578鼠基因:104662同源基因:13245GeneCards:PML Gene
[隱藏]基因本體論描述
分子功能·DNA binding
·transcription coactivator activity
·protein binding
·zinc ion binding
·ubiquitin protein ligase binding
·SUMO binding
·protein homodimerization activity
·SMAD binding
·protein heterodimerization activity
·cobalt ion binding
細胞成分·nucleus
·nucleoplasm
·nucleolus
·cytoplasm
·cytosol
·nuclear matrix
·PML body
·early endosome membrane
·nuclear membrane
·extrinsic component of endoplasmic reticulum membrane
生物過程·response to hypoxia
·regulation of protein phosphorylation
·positive regulation of defense response to virus by host
·transcription, DNA-templated
·regulation of transcription, DNA-templated
·protein complex assembly
·protein targeting
·apoptotic process
·activation of cysteine-type endopeptidase activity involved in apoptotic process
·DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
·cell cycle arrest
·transforming growth factor beta receptor signaling pathway
·common-partner SMAD protein phosphorylation
·SMAD protein import into nucleus
·negative regulation of cell proliferation
·intrinsic apoptotic signaling pathway in response to DNA damage
·intrinsic apoptotic signaling pathway in response to oxidative stress
·response to UV
·response to gamma radiation
·regulation of calcium ion transport into cytosol
·viral process
·negative regulation of angiogenesis
·cytokine-mediated signaling pathway
·myeloid cell differentiation
·negative regulation of cell growth
·PML body organization
·positive regulation of histone deacetylation
·negative regulation of telomere maintenance via telomerase
·endoplasmic reticulum calcium ion homeostasis
·circadian regulation of gene expression
·negative regulation of translation in response to oxidative stress
·response to cytokine
·regulation of circadian rhythm
·intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
·entrainment of circadian clock by photoperiod
·proteasome-mediated ubiquitin-dependent protein catabolic process
·innate immune response
·cell fate commitment
·regulation of MHC class I biosynthetic process
·negative regulation of transcription, DNA-templated
·negative regulation of mitotic cell cycle
·retinoic acid receptor signaling pathway
·protein stabilization
·maintenance of protein location in nucleus
·defense response to virus
·negative regulation of telomerase activity
·positive regulation of apoptotic process involved in mammary gland involution
·interferon-gamma-mediated signaling pathway
·branching involved in mammary gland duct morphogenesis
·intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
·cellular response to interleukin-4
·cellular senescence
·extrinsic apoptotic signaling pathway
·negative regulation of viral release from host cell
·negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
·regulation of double-strand break repair
·positive regulation of extrinsic apoptotic signaling pathway
Sources:Amigo/QuickGO
物種
人類
鼠類
Entrez
5371
18854
Ensembl
ENSG00000140464
ENSMUSG00000036986
UniProt
P29590
Q60953
mRNA序列
NM_002675
NM_008884
蛋白序列
NP_002666
NP_032910
基因位置
Chr 15:
74.29 – 74.34 Mb
Chr 9:
58.22 – 58.25 Mb

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