張熒熒，女，博士，畢業於廈門大學，廈門大學生命科學學院助理教授。
基本介紹
- 中文名：張熒熒
- 畢業院校：廈門大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：程式性壞死的分子機制
- 任職院校：廈門大學生命科學學院
人物經歷,研究方向,學術成果,
人物經歷
2006-2010，廈門大學生命科學學院，本科
2010-2016，廈門大學生命科學學院，博士
2017-至今，廈門大學生命科學學院，助理教授
2006-2010，School of Life Sciences, Xiamen University, B.S.
2010-2016，School of Life Sciences, Xiamen University, Ph.D.
2017-present, School of Life Sciences, Xiamen University, Assistant Professor
研究方向
程式性壞死的分子機制
學術成果
1.Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.Nat Commun. 2017 Feb 8; 8: 14329. doi: 10.1038/ncomms14329
2.Zhang Y, Han J*. Electrophysiologist shows a cation channel function of MLKL.Cell Res. 2016 Jun; 26(6): 643-4.
3.Ren J#, Jia X, Zhao Y, Shi W, Lu J,Zhang Y, Wu J, Liang B, Wu R, Fu G, Han J*. The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells.Cell Mol Immunol. 2017 Jul;14(7):639-642.
4.Huang D#, Zheng X#, Wang ZA#, Chen X, He WT,Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process.Mol Cell Biol. 2017 Feb 15; 37(5)
5.Li, Y. #, Zhong, C.Q. #, Xu, X., Cai, S., Wu, X.,Zhang, Y., Chen, J., Shi, J., Lin, S., and Han, J*. Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files. Nat Methods.Nat Methods. 2015 Oct 5. doi: 10.1038/nmeth.3593.
6.Wu XN#, Yang ZH#, Wang XK,Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis.Cell Death and Differentiation.2014 Jun 6. doi: 10.1038/cdd.2014.77.
7.Wu T, Li Y, Huang D, Han F,Zhang YY, Zhang DW, Han J*. Regulator of G-Protein Signaling 19 (RGS19) and Its Partner Gα-Inhibiting Activity Polypeptide 3 (GNAI3) Are Required for zVAD-Induced Autophagy and Cell Death in L929 Cells.PLoS One. 2014; 9(4): e94634.
8.Wu J#, Huang Z#, Ren J#, Zhang Z, He P, Li Y, Ma J, Chen W,Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han J*. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.Cell Res. 2013; 23(8): 994-1006.
9.Chen W#, Zhou Z#, Li L#, Zhong CQ, Zheng X, Wu X,Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J*. Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling.J Biol Chem. 2013; 288(23): 16247-61.
10.Wu X#, Tian L#, Li J,Zhang Y, Han V, Li Y, Xu X, Li H, Chen X, Chen J, Jin W, Xie Y, Han J*, Zhong CQ*. Investigation of RIP3-dependent protein phosphorylation by quantitative phosphoproteomics.Mol Cell Proteomics. 2012; 11(12): 1640-51.
