張大志，男，同濟大學兼職教授，聚焦抗真菌藥物的研究與開發、藥物靶點研究、螢光探針及其套用。主持承擔國家自然科學基金重點項目和面上項目8項、新藥創製科技重大專項2項、上海市級項目4項。近五年以通訊作者或共同通訊作者發表論文20餘篇，申請專利6項，授權並轉化專利3項，獲批新藥證書2件，獲得2020年教育部科技進步一等獎1項（第1）。
人物經歷,研究方向,主要成就,
人物經歷
張大志，男，同濟大學兼職教授，聚焦抗真菌藥物的研究與開發、藥物靶點研究、螢光探針及其套用。主持承擔國家自然科學基金重點項目和面上項目8項、新藥創製科技重大專項2項、上海市級項目4項。近五年以通訊作者或共同通訊作者發表論文20餘篇，申請專利6項，授權並轉化專利3項，獲批新藥證書2件，獲得2020年教育部科技進步一等獎1項（第1）。
研究方向
1.小分子藥物發現與靶點研究
2.藥物研究新技術研究
主要成就
主持的部分基金課題：
1.重大新藥創製科技重大專項，2019ZX09721001-001-006，抗耐藥真菌新藥NT-2的臨床前研究，164.68萬元，2019-2020
2.國家自然科學基金重點項目，81830106，基於抗耐藥真菌新先導物和新機制的藥物發現研究，293 萬元，2019/01-2023/12
3.國家自然科學基金面上項目，82173786，基於活細胞特異螢光探針檢測的真菌CYP51抑制劑實時原位構效關係探索及其作為抗真菌藥物發現新方法研究，55 萬元，2022/01-2025/12
4.上海市專項項目，抗耐藥真菌藥物研究，500 萬元，2020/03-2022/03
5.上海市 “科技創新行動計畫”生物醫藥科技支撐專項項目, 21S11901300，新型高效抗隱球菌活性化合物的作用機制與結構最佳化研究, 30萬元，2021/07/01-2024/06/30
6.國家自然科學基金面上項目，81673280，新型氮唑類抗真菌先導物結構最佳化及其與靶酶結合模式研究，52 萬元，2017/01-2020/12
發表的部分發表論文：
1.Liping Li#, Hao Wu#, Shuo Zhu, Zhe Ji, Xiaochen Chi, Fei Xie, Yumeng Hao, Hui Lu, Feng Yang, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, and Tingjunhong Ni*. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J. Med. Chem. 2022, 65(16):11257-11269
2.Tingjunhong Ni †, Zichao Ding †, Fei Xie †, Yumeng Hao, Junhe Bao, Jingxiang Zhang, Shichong Yu*,Yuanying Jiang* and Dazhi Zhang*. Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing henylethynyl Pyrazole Side Chains. Molecules. 2022; 27(11): 3370.
3.Liping Li#, Hui Lu#, Xuan Zhang, Malcolm Whiteway, Hao Wu, Shanlun Tan, Jianye Zang, Shujuan Tian, Cheng Zhen, Xianlei Meng, Wanqian Li, Dazhi Zhang*, Min Zhang*, Yuanying Jiang*. Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis. Microbiol Spectr. 2022;e0208522.
4.Ning Wang#, Yumeng Hao#, Xiaowei Feng, Haidan Zhu, Dazhi Zhang, Ting Wang∗, Xiaoyan Cui,∗. Silicon-substituted rhodamines for stimulated emission depletion fluorescence nanoscopy. Chinese Chemical Letters. 33 (2022) 133–140
5.Xiaofeng Lin#, Mengting Fan#, Ni Li, Jiaojiao Yang, Haidan Zhu, Bo Chen, Junru Zhu, Dazhi Zhang*, Ting Wang*, Xiaoyan Cui*. Phosphorus-substituted rhodamines for bioimaging of the lysosomal peroxynitrite in vivo. Dyes and Pigments 2022，201: 110201
6.Mengting Fan, Haiyan An, Chuanfeng Wang, Shuhui Huo, Ting Wang*, Xiaoyan Cui*, Dazhi Zhang*. STED imaging the dynamic of lysosomes by dually fluorogenic Si-rhodamine. Chemistry-A European Journal, 2021,27(37): 9620-9626
7.Huai-Huai Dong, Yuan-Hua Wang, Xue-Mi Peng, He-Yang Zhou, Fei Zhao, Yuan-Ying Jiang, Da-Zhi Zhang*, Yong-Sheng Jin*. Synergistic antifungal effects of curcumin derivatives as fungal biofilm inhibitors with fluconazole. Chem Biol Drug Des. 2021,97(5): 1079-1088
8.Zichao Ding#; Chuanfeng Wang#; Mengting Fan; Mengyuan Zhang; Yao Zhou; Xiaoyan Cui*; Dazhi Zhang*, Ting Wang*. Far-red imaging of b-galactosidase through a phospha-fluorescein. Chem. Commun.; 2020,56, 13579
9.Quan-Zhen Lv,Ting-Jun-Hong Ni,Li-Ping Li,Tian Li,Da-Zhi Zhang*, Yuan-Ying Jiang*. A New Antifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces Oxidative Damage in Candida albicans. Front Cell Infect Microbiol. 2020;10:578956,
10.Fei Xie#; Tingjunhong Ni#; Zichao Ding#; Yumeng Hao; Ruina Wang; Ruilian Wang; Ting Wang; Xiaoyun Chai; Shichong Yu; Yongsheng Jin; Yuanying Jiang*; Dazhi Zhang*. Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents. Bioorg Chem. 2020;101:103982
11.Ren-Yi Lu#; Ting-Jun-Hong Ni#; Jing Wu#; Lan Yan; Quan-Zhen Lv; Li-Ping Li; Da-Zhi Zhang*; Yuan-Ying Jiang*. New Triazole NT-a9 Has Potent Antifungal Efficacy against Cryptococcus neoformans In Vitro and In Vivo. Antimicrob Agents Chemother 2020;64(2)：e01628-19
12.Xin Huang#; Yu Liu#; Tingjunhong Ni#; Liping Li; Lan Yan; Maomao An; Dazhi Zhang*; Yuanying Jiang*. 11g, a Potent Antifungal Candidate, Enhances Candida albicans Immunogenicity by Unmasking β-Glucan in Fungal Cell Wall. Front Microbiol 2020;11:1324
