左正宏，男，畢業於廈門大學，博士，廈門大學生命科學學院教授、博士生導師。
基本介紹
- 中文名：左正宏
- 畢業院校：廈門大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：環境醫學與分子毒理學
- 職務：博士生導師
- 職稱：教授
- 任職院校：廈門大學
個人經歷,研究領域,學術成果,榮譽獎項,
個人經歷
安徽師範大學學士（1996）；
廈門大學理學碩士（1999）；
廈門大學理學博士（2005）；
紐約大學醫學院訪問學者（2009）；
2005年至今為廈門大學生命科學學院助理教授、副教授、教授；
現為廈門大學生命科學學院黨委書記,教育部大學生物學課程教學指導委員會委員
研究領域
從事環境醫學與分子毒理學研究，特別關注持久性污染物和新型污染物與人類重要疾病（如：糖尿病、新生兒出生缺陷、心血管疾病、神經退行性病變、多囊卵巢綜合徵等）的關聯以及毒性機制。主要開展以下研究：（1）污染物的生殖、發育及神經毒性效應與機制研究；（2）轉基因斑馬魚和海水青鱂套用研究。
學術成果
1.Chengyong He*, Fengkai Ruan, Shengwei Jiang, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma*,Zhenghong Zuo*, 2020. Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice and Human Cells.Small, 2001371.
2.Yixi Zhou, Chao Shen, Jinpeng Ruan, Chengyong He, Meng Chen, Chonggang Wang,Zhenghong Zuo* 2020. Generation and application of a Tg(cyp1a:egfp) transgenic marine medaka (Oryzias melastigma) line as an in vivo assay to sensitively detect dioxin-like compounds in the environment,J Hazard Mater, 2020.122192.
3.Chenyang Ji, Chao Shen, Yixi Zhou, Kongyang Zhu, Zhe Sun,Zhenghong Zuo*, Meirong Zhao*, 2019. AhR Agonist Activity Confirmation of Polyhalogenated Carbazoles (PHCZs) Using an Integration of in Vitro, in Vivo, and in Silico Models,Environ Sci Technol, 53(24):14716-14723.
4.Zhibing Yang, Junxia Shi, Zhizhun Guo, Mingyue Chen, Chonggang Wang, Chengyong He*,Zhenghong Zuo*, 2019, A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats,Chemosphere, 9, 231: 151-160
5.Jinpeng Ruan, Jiaojiao Guo, Yameng Huang, Yunzi Mao, Zhenggang Yang,Zhenghong Zuo* 2019. Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice,Environ Res, 181:108909
6.Yixi Zhou, Chao Shen, Hong Du, Yuanyuan Bao, Chengyong He, Chonggang Wang,Zhenghong Zuo* 2019. Bioassay system for the detection of aryl hydrocarbon receptor agonists in waterborne pesticides using zebrafish cyp1a1 promoter-luciferase recombinant hepatic cells.Chemosphere. 220: 61-68.
7.Chao Shen, Yixi Zhou, Jinpeng Ruan, Yung-Jen Chuang, Chonggang Wang,Zhenghong Zuo* 2018. Generation of a Tg(cyp1a-12DRE:EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds,Aquat Toxicol, 205：174-181.
8.Jiaojiao Guo, Chonggang Wang, Zhizhun Guo,Zhenghong Zuo* 2018. Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat,Environ Pollut, 239:261-271.
9.Yuanchuan Wang, Chao Shen, Chonggang Wang, Yixi Zhou,Zhenghong Zuo* 2018. Maternal and embryonic exposure to the water soluble fraction of crude oil or lead induces behavioral abnormalities in zebrafish (Danio rerio), and the mechanisms involved,Chemosphere, 191:7-16.
10.Dongxu Gao, Chonggang Wang, Zhihui Xi, Yuanchuang Wang,Zhenghong Zuo* 2017. Early-life benzo[a]pyrene exposure causes neurodegenerative syndromes in adult zebrafish (Danio rerio) and the mechanism involved，Toxicol Sci，157(1):74-84.
11.Zhizhun Guo, Huiling Qiu, Lingling Wang, Lijun Wang, Chonggang Wang, Meng Chen*,Zhenghong Zuo* 2017. Association of serum organochlorine pesticides concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population,Chemosphere, 171:595-600.
12.Lixing Huang, Zihui Xi, Chonggang Wang, Youyu Zhang, Zhibing Yang, Shiqi Zhang, Yixin Chen,Zhenghong Zuo* 2016. Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation.Scientific Reports6:20105.
13.Meifan Wu, Di Wu, Chonggang Wang, Guo, Z.Z., Bowen Li,Zhenghong Zuo* 2016. Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5.J Hazard Mater302:304-313.
14.Dongxu Gao, Meifan Wu, Chonggang Wang, Yuanchuang Wang,Zhenghong Zuo* 2015. Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio).Aquat Toxicol167:200-208.
15.Shiqi Zhang, Tian Wu, Meng Chen, Zhizhun Guo, Zhibing Yang,Zhenghong Zuo*, Chonggang Wang * 2015. Chronic exposure to Aroclor 1254 disrupts glucose homeostasis in male mice via inhibition of the insulin receptor signal pathway.Environ Sci Technol49(16):10084-10092.
16.Zhenghong Zuo, Tongjian Cai, Jingxia Li, Dongyun Zhang, Yonghui Yu, Chuanshu Huang* 2012. Hexavalent Chromium Cr(VI) Upregulates COX-2 Expression through an NFκB/c-Jun/AP-1-dependent Pathway.Environ Health Perspect120(4):547-553.
17.Zhenghong Zuo, Tian Wu, Moudan Lin, Shiqi Zhang, Feihuan Yan, Zhibin Yang, Yuanchuan Wang, Chonggang Wang*. 2014. Chronic exposure to tributyltin chloride induces pancreatic islet cell apoptosis and disrupts glucose gomeostasis in male mice.Environ Sci Technol 48（9）：5179-86.
18.Lixing Huang, Dongxu Gao, Youyu Zhang, Chonggang Wang,Zhenghong Zuo*, 2014. Exposure to low dose benzo[a]pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish.J Hazard Mater276C:377-382.
19.Lixing Huang, Chonggang Wang, Youyu Zhang, Meifang Wu,Zhenghong Zuo*, 2013. Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved.J Hazard Mater.261c:172-180.
20.Youyu Zhang, Lixing Huang, Chonggang Wang, Dongxu Gao,Zhenghong Zuo*. 2013. Phenanthrene exposure produces cardiac defects during embryo development of zebrafish (Danio rerio) through activation of MMP-9.Chemosphere93（6）：1168-1175.
21.Jiali Cai, Chonggang Wang, Lixing Huang, Meng Chen,Zhenghong Zuo*. 2013. A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis.Toxicol Sci134(2): 382-90.
22.Zhenghong Zuo*, Chonggang Wang, Meifang Wu, Yuqing Wang, Yixin Chen. 2012. Exposure to Tributyltin and Triphenyltin induces DNA damage and alters nucleotide excision repair gene transcription in Sebastiscus marmoratus liver.Aquat Toxicol122-123:106-112.
23.Chengyong He, Chonggang Wang, Yuling Zhou, Jian Li*,Zhenghong Zuo*. 2012. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus).Neurotoxicology33(4):758-762.
24.Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen,Zhenghong Zuo*. 2012. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms.Aquat Toxicol116-117：109-115.
25.Youyu Zhang, Chonggang Wang, Lixing Huang, Rong Chen, Yixin Chen,Zhenghong Zuo*. 2012. Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos.Aquat Toxicol114-115:119-124.
26.Lixing Huang, Chonggang Wang, Youyu Zhang, Jian Li, Yuanfu Zhong, Yulin Zhou, Yixin Chen,Zhenghong Zuo*. 2012. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos.Chemosphere. 87（4）:369-375.
27.Zhenghong Zuo, Suzhen Chen, Tian Wu, Jiliang Zhang, Ying Su, Yixin Chen, Chonggang Wang*. 2011. Tributyltin causes obesity and hepatic steatosis in male mice.Environ Toxicol26(1): 79-85.
28.Jiali Cai, Chonggang Wang, Tian Wu, João Manuel Lopes Moreno, Yuanfu Zhong, Huang X,Zhenghong Zuo*. 2011. Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure.Toxicology287(1-3): 21-28.
29.Bowen Li, Chonggang Wang, Ang Yu, Yixin Chen,Zhenghong Zuo*. 2010. Identification of differentially expressed genes in the brain of Sebastiscus marmoratus in response to tributyltin exposure.Aquat Toxicol99(2): 248-255.
30.Zhenghong Zuo*, Jiali Cai, Xinli Wang, Bowen Li, Chonggang Wang, Yixin Chen. 2009. Acute administration of tributyltin and trimethyltin modulate glutamate and N-methyl-D-aspartate receptor signaling pathway in Sebastiscus marmoratus.Aquat Toxicol92(1): 44-49.
31.Yuqing Wang, Chonggang Wang, Jiliang Zhang, Yixin Chen,Zhenghong Zuo*. 2009. DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver.Aquat Toxicol95(2): 93-98.
榮譽獎項
上海市科學技術進步獎一等獎（2010）
國家科學技術進步獎二等獎（2011）
廈門市科學技術進步獎三等獎（2014）
高等教育國家級教學成果獎二等獎（2018）
2016-2019年度廈門市優秀教師（2019）
