宋任濤

宋任濤，男，上海大學教授，博士生導師。

基本介紹

• 中文名：宋任濤
• 國籍：中國
• 民族：漢
• 職業：博士生導師
• 畢業院校：華東化工學院
• 代表作品：曾獲2004年獲美國農業部傑出成就集體獎

教育背景

1992年7月本科畢業於華東化工學院（現華東理工大學）生物化學專業；1997年7月博士畢業於中國科學院上海植物生理研究所，植物分子遺傳國家重點實驗室，遺傳學專業。1997年7月至2004年5月在美國新澤西州Rutgers大學Waksman研究所從事植物分子遺傳和植物基因組學博士後研究工作。2004年6月起，任上海大學生命科學學院教授。2005年12月起任上海市能源作物育種及套用重點實驗室主任。

學術成果

曾獲2004年獲美國農業部傑出成就集體獎；2004年度上海市“曙光學者”；2005年度上海市青年科技啟明星，2005年度上海市“浦江人才”，2006年度教育部新世紀優秀人才，霍英東教育基金獲得者。

承擔有國家自然科學基金、國家“863”計畫、國家“973”計畫，以及國家轉基因重大專項等科研項目。至2011年底，共發表SCI論文41篇，SCI引用2200餘次。

主講課程：遺傳學，轉基因技術與安全（新生研討課）

研究方向

1. 玉米分子遺傳學研究。主要針對玉米籽粒的蛋白品質性狀，開展重要突變體的基因克隆和功能分析。重點針對玉米籽粒Opaque突變體（為主要影響籽粒蛋白含量的一類突變體），開展圖位克隆和功能分析。並在此基礎上開展對玉米主要儲藏蛋白的轉錄調控機制研究。

2. 玉米基因組學研究。功能基因組學研究：利用玉米Ac轉座子系統，創建玉米功能基因組學研究的遺傳材料，並探索相應的研究方法。比較基因組學研究：開展玉米重要染色體位點的比較基因組學研究，特別關注玉米關鍵性狀的馴化問題。

以往主要研究基礎：

1. 開展了針對玉米重要性狀的分子遺傳學和基因組學研究，其中對玉米主要馴化基因tb1的馴化突變位點的研究發表在Cell Research（2011）。對玉米重要籽粒突變體Opaque7的圖位克隆研究發表在Genetics（2011），是國內首個發表的玉米圖位克隆研究工作。構建了國內首個可用於大規模玉米功能基因組研究的玉米Ac轉座子突變系統（Genetica，2010）。

2. 系統開展了針對玉米主要儲藏蛋白（醇溶蛋白）的基因組學、比較基因組學和功能基因組學研究，相應研究以第一作者發表了Genome Research （2001），Genome Research（2002），Plant Physiology（2002）和PNAS（2003）；以通訊作者發表了Plant Mol Biology（2009），Plant Mol Biology（2010）和Genome（2010）。

3. 在玉米中最先嘗試了RNAi轉基因技術，並用單個RNAi構建沉默一個基因家族，以第二作者發表Genetics（2003）；在玉米中嘗試了超大片段的遺傳轉化，也是首次完整轉化一個大型的簇狀基因家族（高梁22kD醇溶蛋白基因簇），以第一作者發表Nucleic Acids Research（2004）。實驗室建有成熟的玉米轉基因技術平台，承擔有轉基因育種國家重大專項任務。

4. 參與了國際水稻基因組計畫中第10號染色體的序列測定工作，具體負責了Rutgers大學分攤的區段，是Science（2003）和Nature（2005）的共同作者，並因此得到美國農業部頒發的獎勵。回國後還開展了對14個野生稻在Moc1位點的比較基因組學分析，以並列第一作者發表PNAS（2009）。

5. 開展了極端耐逆生物（鹽藻Dunaliella viridis和鹽芥Thellungiella halophila）的功能基因研究，報導了多個獨特功能基因的克隆和功能分析，以通訊作者發表Plant Molecular Biology等SCI論文10篇。

研究論文

1. Wang G, Xu J, Tang Y, Zhou L, Wang F, Xu Z and Song R* (2011) Molecular characterization of a genomic interval with highly uneven recombination distribution on maize chromosome 10L. Genetica 139: 1109-1118

2. Wang G, Sun X, Wang G, Wang F, Gao Q, Sun X, Tang Y, Chang C, Lai J, Zhu L, Xu Z and Song R* (2011) Opaque7 encodes an Acyl Activating Enzyme-lie protein that affects storage protein synthesis in maize endosperm. Genetics 189(4): 1281-1295

3. Zhou L, Zhang J, Yan J and Song R* (2011) Two transposable element insertions are causative mutations for the major domestication gene teosinte branched 1 in modern maize. Cell Research 21: 1267-1270.

4. Wang G, Wang G, Zhang X, Wang F and Song R* (2011) Isolation of high quality RNA from cereal seeds containing high level of starch. Phytochem Anal. (DOI 10.1002/pca.1337)

5. Zhu C, Xu Z and Song R* (2011) The endoglucanase from Bacillus subtilis BEC-1 bears halo tolerant, acidophilic and dithiothreitol stimulated enzyme activity. World J Microbiol Biotechnol (DOI 10.1007/s11274- 011- 0767-6)

6. Yuan H, Meng X, Gao Q, Qu W, Xu T, Xu Z and Song R* (2011) The characterization of two peroxiredoxin genes in Dunaliella viridis privides insights into antioxidative response to salt stress. Plant Cell Rep 30 (8): 1503-1512.

7. Song T, Gao Q, Xu Z and Song R* (2011) The cloning and characterization of two ammonium transporters in the salt-resistant green alga Dunaliella viridis. Mol Bio Rep 38 (7): 4797-4804.

8. Meng X, Xu Z and Song R* (2011) Molecular cloning and characterization of a vacuolar H+-pyrophosphatase from Dunaliella viridis. Mol Bio Rep 38(5): 3375-3382.

9. Zhang N, Wang F, Meng X, Luo S, Li Q, Dong H, Xu Z and Song R* (2011) Molecular cloning and characterization of a trehalose-6-phosphate synthase/phosphatase from Dunaliella viridis. Mol Bio Rep 38(4): 2241-2248.

10. Zhu C, Zhang J, Tang Y, Xu Z and Song R* (2011) Diversity of methanogenic archaea in a biogas reactor fed with swine faces as the mono-substrate by mcrA analysis. Microbiol Res 166: 27-35.

11. Li M, Li P, Song R and Xu Z （2010）An induced hypersensitive-like response limits expression of foreign peptides via a recombinant TMV-based vector in a susceptible tobacco. PLoS One 5(11): e15087.

12. Wang F, Li Z, Fan J, Li P, Hu W, Wang G, Xu Z and Song R* (2010) An Ac transposon system based on maize chromosome 4S for isolating long-distance-transposed Ac tags in the maize genome. Genetica 138: 1261-1270.

13. Zhou L, Huang B, Meng X, Wang G, Wang F, Xu Z and Song R* (2010) The amplification and evolution of orthologous 22-kD α-prolamin tandemly arrayed genes in coix, sorghum and maize genomes. Plant Mol Bio 74(6): 631-643.

14. Meng X, Huang B, Zhou L, He Y, Chen Q, Yuan Y, Xu Z and Song R* (2010) Construction of a Coix BAC library and isolation of the 22 kDa α-coixin gene cluster. Genome 53: 667-674.

15. Sun X, Meng X, Xu Z, Song R* (2010) Expression of the 26S proteasome subunit RPN10 is upregulated by salt stress in Dunaliella viridis. J Plant Physiol 167: 1003-1008.

16. Wang GF, Wang H, Zhu J, Zhang J, Zhang X, Wang F, Tang Y, Mei B, Xu Z and Song R* (2010) An expression analysis of 57 transcription factors derived from ESTs of developing seeds in Maize (Zea mays). Plant Cell Rep 29: 545-559.

17. Yan Q, Zhao M, Miao H, Ruan W and Song R (2010) Couple of the hydrogen and polyhyroxyalkanoates (PHA) production through anaerobic digestion from Taihu blue algae. Bioresource Technology 101: 4508-4512.

18. Han Y, Wang G, Liu Z, Liu J, Yue W, Song R, Zhang X and Jin W (2010) Divergence in centromere structure distinguishes related genomes in Coix lacryma-jobi and its wild relative. Chromosoma 119: 89-98.

19. He Y, Meng X, Fan Q, Sun X, Xu Z and Song R* (2009) Cloning and characterization of two novel chloroplastic glycerol-3-phosphate dehydrogenases from Dunaliella viridis. Plant Mol Bio 71: 193-205.

20. Feng L, Zhu J, Wang G, Tang Y, Chen H, Jin W, Wang F, Mei B, Xu Z and Song R* (2009) Expressional profiling study revealed unique expressional patterns and dramatic expressional divergence of maize α-zein super gene family. Plant Mol Bio 69:649-659.

21. Lu F, Ammiraju JS, Sanyal A, Zhang S, Song R, Chen J, Li G, Sui Y, Song X, Cheng Z, de Oliveira AC, Bennetzen JL, Jackson SA, Wing RA, Chen M. (2009) Comparative sequence analysis of MONOCULM1-orthologous regions in 14 Oryza genomes. Proc Natl Acad Sci USA. 106(6): 2071-6. (Co-first Author)

22. Guan Z, Meng X, Sun Z, Xu Z and Song R* (2008) Characterization of duplicated Dunaliella viridis SPT1 genes provides insights into early gene divergence after duplication. Gene 423(1):36-42.

23. Fang Q, Liu J, Xu Z and Song R* (2008) Cloning and characterization of a flowering time gene from Thellungiella halophila. Acta Biochim Biophys Sin. 40(8):747-53.

24. Guan Y, Chen Q, Pan J, Li Z, He H, Wu A, Song R and Cai R (2008) Construction of a BAC library from cucumber (Cucumis sativus L.) and identification of linkage group specific clones. Progress in Natural Science 18(2): 143-147.

25. Li Q, Jiang L, Li M, Li P, Zhang Q, Song R and Xu Z (2007) Morphology and stability changes of recombinant TMV particles caused by a cysteine residue in the foreign peptide fused to the coat protein. J Virol Methods 140(1-2):212-217.

26. Sun X, Tang Y, Meng X, Zhang W, Li S, Deng Z, Xu Z and Song R* (2006) Sequencing and analysis of a genomic fragment provides an insight into the Dunaliella viridis genomic sequence. Acta Biochim Biophys Sin. 38(11): 812-820.

27. Fang Q, Xu Z and Song R* (2006) Cloning, characterization and genetic engineering of FLC homologue in Thellungiella halophila. Biochem Biophys Res Commun. 347: 707-714.

28. Lu Q, Xu Z and Song R* (2006) OsFY, a Homolog of AtFY, Encodes a Protein that can Interact with OsFCA-g in Rice (Oryza sativa L.) Acta Biochim Biophys Sin. 38(7): 492–499.

29. Li Q, Li M, Jiang L, Zhang Q, Song R and Xu Z (2006) TMV recominants encoding fused foreign transmembrane domains to the CP subunit caused local necrotic response to susceptible tobacco. Virology 384: 253-259.

30. Li Q, Gao X, Sun Y, Zhang Q, Song R and Xu Z (2006) Isolation and characterization of a sodium-dependent phosphate transporter gene in Dunaliella viridis. Biochem Biophys Res Commun. 340(1): 95-104.

31. International Rice Genome Sequencing Project (2005) The map-based sequence of the rice genome. Nature 436: 793-800.

32. Song R, Segal G and Messing J (2004) Expression of sorghum 10-member kafirin gene cluster in maize endosperm. Nucleic Acid Research 32(22): e189

33. Segal G, Song R and Messing J (2003) A new opaque variant of maize by a single dominant RNA-interference-inducing transgene. Genetics 165: 387-397.

34. Song R and Messing J (2003) Gene expression of a gene family in maize based on noncollinear haplotypes. Proc Natl Acad Sci USA 100: 9055-9060.

35. Wu, L., Fan, J., Jiang, L., Wang, H., Song, R., Zhang, Q., Zhu, H., Li, N., Liu, Z. and Xu, Z. (2003) A specific cis-hairpin ribozyme facilitates infection of a TMV-based DNA vector in tobacco protoplasts. J Virol Methods 111:101-9.

36. The Rice Chromosome 10 Sequencing Consortium (2003) In-depth view of structure, activity, and evolution of rice chromosome 10. Science 300: 1566-1569.

37. Song R and Messing J (2002) Contiguous genomic DNA sequence comprising the 19-kDa-zein gene family from Zea mays. Plant Physiology 130: 1626-1635.

38. Song R, Llaca V and Messing J (2002) Mosaic organization of orthologous sequences in grass genomes. Genome Research 12: 1549-1555.

39. Park W, Li J, Song R, Messing J and Chen X (2002) CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism. Current Biology 12: 1484-1495.

40. Song R, Llaca V, Linton E and Messing J (2001) Sequence, regulation and evolution of the maize 22 kDa a zein gene family. Genome Research 11: 1817-1825.

41. Song, R., Li, J., Jin , H., Zhang, Q. and Xu, Z. (1997) Influence of substrate and ribozyme sequences on the functions of ribozyme. Acta Biochim Biophys Sin. 29: 61-68.