周文忠，男，博士，中國農業大學動物醫學院教授、博士生導師。
基本介紹
- 中文名：周文忠
- 出生日期：1962年2月
- 畢業院校：復旦大學
- 學位/學歷：博士
- 專業方向：遺傳學
- 任職院校：中國農業大學
人物經歷,研究方向,發表論文,獲獎記錄,
人物經歷
1993年畢業於復旦大學遺傳學專業，獲得理學博士學位。之後分別在上海醫科大學（復旦大學醫學部）、日本大阪大學細胞及分子生物學研究所、美國內布拉斯加大學醫學中心、加拿大麥克馬斯特大學醫學部等單位從事教學和科研工作。2005年歸國至今在中國農業大學動物醫學院從事納米獸藥和納米佐劑相關科研工作，承擔過“863計畫”，“國家科技支撐計畫”等課題。
研究方向
（1）納米獸藥：納米獸藥的構建、納米技術促進獸藥吸收、改善獸藥功效的作用、影響因素及其機理，納米獸藥的安全性等；
（2）納米佐劑：納米佐劑的構建、納米佐劑對抗原蛋白和基因疫苗細胞和體液免液的增強作用、納米粒的理化特徵對其佐劑效應的影響等。
發表論文
獲得了具有自主智慧財產權的成果，以第一作者或通訊作者發表SCI收錄論文20餘篇，在該領域取得一系列創新性成果發表在Part Fibre Toxicol，Nanomedicine，Colloids Surf B Biointerfaces，Int J Nanomedicine，IET Nanobiotechnol., Drug Deliv.等極具行業影響力期刊。其代表論文有：
1. 第一作者論文
W-Z Zhou, D.S.B. Hoon, S.K.S. Huang, S. Fujii, K. Hashimoto, R. Morishita, and Y. Kaneda, 1999, RNA melanoma vaccine: Induction of anti-tumor immunity by human Glycoprotein 100 mRNA immunization. Human Gene Therapy. 10 (16): 2719-2724.
W-Z Zhou, Y. Kaneda, S.K.S. Huang, R. Morishita, and D.S.B. Hoon, 1999, Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine. Gene Therapy. 6: 1768-1773.
Wenzhong Zhou, Jinshui Yang et al., 1996, Introduction of a foreign gene into rice cells by particle bombardment. ACTA BIOLOGIAE EXPREMENTALIS SINICA. 29(1): 89-93.
2. 通訊作者論文
Wang T, Chen X, Lu M, Li X, Zhou W. Preparation, characterization and antibacterial activity of a florfenicol-loaded solid lipid nanoparticle suspension. IET Nanobiotechnol. 2015 Dec;9(6):355-61. doi: 10.1049iet-nbt. 2015.0012.
Chen XJ, Wang T, Lu MM, Zhu LY, Wang Y, Zhou WZ. Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes. Int J Nanomedicine. 2014 May 27;9:2655-64. doi: 10.2147IJN.S58898. eCollection 2014.
Wang Y, Zhu LY, Dong Z, Xie SY, Chen XJ, Lu MM, Wang XF, Li XH, Zhou WZ. Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions. Colloids Surf B Biointerfaces, 98:105-11, 2012.
Wang XF, Zhang SL, Zhu LY, Xie SY, Dong Z, Wang Y, Zhou WZ. Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo. Vet J. 2012 Jan; 191(1):115-20. Epub 2011 Sep 6.
Xie S, Pan B, Shi B, Zhang Z, Zhang X, Wang M, Zhou W. Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm. Int J Nanomedicine, 2011; 6:2367-74. Epub 2011 Oct 18.
Xie S, Wang F, Wang Y, Zhu L, Dong Z, Wang F, Li X, Zhou W. Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles. Part Fibre Toxicol. 2011 Nov 20;8:33. doi: 10.11861743-8977-8-33.
Zhu, LY, Xie SY, Dong Z, Wang XF, Wang Y, Zhou WZ. Effects of PLGA on preparation and characteristics of plasmid DNA-loaded solid lipid nanoparticles. IET Nanobiotechnol, 2011 Sep; 5(3):79-85.
Dong Z, Xie S, Zhu L, Wang Y, Wang X, Zhou W. Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. Drug Deliv. 2011 Aug; 18(6):441-50. Epub 2011 May 10.
Xie S, Zhu L, Dong Z, Wang Y, Wang X, Zhou W. Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles. Int J Nanomedicine, 2011, 6; 547-555.
Xie S, Zhu L, Dong Z, Wang X, Wang Y, Li X, Zhou W. Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: Influences of fatty acids. Colloids Surf B Biointerfaces. 2011 Apr 1;83(2):382-7. Epub 2010 Dec 14.
Xie S, Pan B, Wang M, Zhu L, Wang F, Dong Z, Wang X, Zhou W. Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles. Nanomedicine, 2010 Jul; 5(5):693-701.
Li S, Zhao B, Wang F, Wang M, Xie S, Wang S, Han C, Zhu L, Zhou W. Yak interferon-alpha loaded solid lipid nanoparticles for controlled release. Res Vet Sci. 2010 Feb; 88(1):148-53. Epub 2009 Aug 3.
Xie S, Wang S, Zhu L, Wang F, Zhou W. The effect of glycolic acid monomer ratio on the emulsifying activity of PLGA in preparation of protein-loaded SLN. Colloids Surf B Biointerfaces. 2009 Nov 1; 74(1):358-61. Epub 2009 Aug 12.
Wang SL, Xie SY, Zhu LY, Wang FH, Zhou WZ. Effects of PLGA as a co-emulsifier on the preparation and hypoglycemic activity of insulin-loaded solid lipid nanoparticles. IET Nanobiotechnol. 2009 Dec; 3(4):103-8.
Han C, Qi CM, Zhao BK, Cao J, Xie SY, Wang SL, Zhou WZ. Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. J Vet Pharmacol Ther. 2009 Apr; 32(2):116-23.
Xie, S.Y., Wang, S.L., Zhao, B.K., Han, C., Zhou, W. Z. Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles，Colloids Surf B Biointerfaces. 2008 Dec 1; 67(2):199-204. Epub 2008 Aug 27.
獲獎記錄
獲得內蒙古科技進步一等獎、中華農業科技獎二等獎、“北京市科學技術獎二等獎”等省市級獎勵。獲得授權發明專利多項，參與制定奶牛性控國家標準2項。
