基本介紹
- 中文名：何志洲
- 畢業院校：中科院上海生理所
- 學位/學歷：博士
- 職業：教師
- 任職院校：寧波大學醫學院
人物經歷,學術成果,
人物經歷
1983年畢業於南京鐵道醫學院（現東南大學醫學院）。
1990年獲中科院上海生理所博士學位（師從梁之安教授）。
1992-1995年在美國西北大學Peter Dallos實驗室做博士後。
學術成果
代表論著
Mao ZP, Zhao LJ, Pu LC, Wang MX, Zhang Q, He DZ (2013). How well can centenarians hear?PLoS One8(6):e65565. doi: 10.1371/journal.pone.0065565.
Zhang Q, Liu HZ, McGee J, Walsh EJ, Soukup GA, He DZ (2013). Identifying microRNAs involved in degeneration of the organ of Corti during age-related hearing loss. PLoS One 8(4), e62786. Doi:10.1371/journal.pone.0062786.
Tang J, Pecka J, Tan XT, Beisel KW, He DZ (2012). Lizard and frog prestin: Evolutionary insight into functional changes. PLoS One 8(1), e54388. doi: 10.1371/journal.pone.0054388.
Yang SM, Chen W, Guo WW, Sun JH, Young WY, Jia SP, He DZZ (2012). Regeneration of stereocilia of cochlear hair cells by forced Atoh1 expression in the adult mammalian cochlea.PLoS One7(9),e46355. doi:10.1317/journal. pone.0046355.
Tan XD, Pecka JL, Tang J, Lovas S, Beisel KW & He DZZ (2012). An eleven-amino-acid motif is a structural adaptation that facilitates motor capability of eutherian prestinJ Cell Sci125, 1039-1047.
Tang J, Pecka J, Tan XD, Beisel KW & He DZZ (2011). Engineered pendrin protein, an anion transporter and molecular motor.J Biol Chem286, 31014-31021.
Tan XD, Pecka J, Tang J, Okoruwa OE, Zhang Q, Beisel KW & He DZZ (2011). From zebrafish to mammal: Functional evolution of prestin, the motor protein of cochlear outer hair cells.J Neurophysiol105, 36-44. This publication is highlighted by Faculty 1000 (http://f1000.com/).
He DZZ, Jia SP, Zuo J, Latham S, Riordan GP, Kachar B (2010) Prestin function and the structure of the lateral membrane of outer hair cells. Cytoskeleton 67, 43-55.
Jia SP, Yang SM, Guo WW, He DZZ (2009) Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia.J Neurosci29, 15277-15285.
Dallos P, Wu XD, Gao J, Wang X, Jia SP, Anderson CT, Zhen J, Cheatham MA, He* DZZ & Zuo* J (2008) Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron58, 333-339. *contribute equally
Gao JG, Wang X, Wu XD, Aguinaga S, Huynh K, Jia SP, Matsuda K, Patel M, Zheng J, Cheatham MA, He DZZ, Dallos P & Zuo J (2007). Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier.Proc Natl Acad Sci USA 104, 12542-12547.
Albert JT, Winter H, Schaechinger TJ, Weber T, Wang X, He DZZ, Geisler H-S, Hendrich O, Zimmermann U, Göpfert MC, Oliver D & Knipper M (2007). Voltage-sensitive prestin orthologue expressed in zebrafish hair cells.J Physiol 580,451-461.
Jia SP, Dallos P & He DZZ (2007). Mechanoelectric transduction of adult inner hair cells. J Neurosci 27, 1006-1014.
He DZZ, Zheng J, Kalinec F, Kakehata S, & Santos-Sacchi J (2006). Tuning in to the amazing outer hair cell: Membrane wizardry with a twist and a shout.J Memb Biol 209, 1-16.
Jia SP, & He DZZ (2005). Motility-associated hair-bundle motion in mammalian outer hair cells.Nature Neurosci 8, 1024-1034.
He DZZ, Jia SP & Dallos P (2004). Mechano-electrical transduction of adult outer hair cells studied in a gerbil hemicochlea.Nature 429, 766-770.
He DZZ, Jia SP & Dallos P (2003). Prestin and the dynamic stiffness of cochlear outer hair cells.J Neurosci 23, 8210-8218.
He DZZ, Beisel KW, Chen L, Ding D-L, Fritzsch B & Salvi R (2003). Chick hair cells do not exhibit voltage-dependent somatic motility.J Physiol 546, 511-520. This publication is highlighted by Faculty 1000 (http://f1000.com/).
Liberman MC, Gao J, He DZZ, Wu XD, Jia SP & Zuo J (2002). Prestin is required for outer hair cell motility and the cochlear amplifier.Nature 419, 300-304.
Oliver D, He DZZ, Klocker N, Ludwig J, Schulte U, Waldegger S, Ruppersberg JP, Dallos P & Fakler B (2001). Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.Science 292, 2340-2343.
Zheng J, Shen WX, He DZZ, Long K, Madison LD & Dallos P (2000). Prestin is the motor protein of cochlear outer hair cells.Nature 405, 149-155.
He DZZ & Dallos P (2000). Properties of voltage-dependent somatic stiffness of cochlear outer hair cells.J Assoc Res Otolaryngol 1, 64-81.
He DZZ & Dallos P (1999). Development of acetylcholine-induced responses in neonatal gerbil outer hair cells.J Neurophysiol 81, 1162-1170.
He DZZ & Dallos P (1999). Somatic stiffness of cochlear outer hair cells is voltage-dependent.Proc Natl Acad Sci USA 96, 8223-8228.
He DZZ (1997). Relationship between the development of outer hair cell electromotility and efferent innervation: A study in cultured organ of Corti of neonatal gerbils.J Neurosci 17, 3634-3643.
Dallos P, He DZZ, Lin X, Sziklai I, Mehta S & Evans BN (1997). Effects of acetylcholine on outer hair cell electromotility.J Neurosci 17, 2212-2226.
He DZZ, Evans BN & Dallos P (1994). First appearance and development of electromotility in neonatal gerbil outer hair cells.Hear Res 78, 77-90.
